Review: Micro- and nanostructured surface engineering for biomedical applications

Luong-Van, Emma; Rodríguez, Isabel; Low, Hong Yee; Elmouelhi, Noha; Lowenhaupt, Bruce; Natarajan, Sriram; Lim, Chee Tiong; Prajapati, Rita; Vyakarnam, Murty; Cooper, Kevin R.

doi:10.1557/jmr.2012.398

Cited by 74 publications

(52 citation statements)

References 71 publications

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“…Topographical surfaces also influence adhesion of bacteria 108,109 and platelets 110,111 , and may affect protein adsorption 112 . The engineering of surfaces with well-defined micro- and nanoscale topographies has become relevant as a strategy to control biological responses 113,114 .…”

Section: Protein Adsorption and Platelet Adhesion On Biomaterials Smentioning

confidence: 99%

“…There is evidence that surface topography might influence the amount of protein adsorbed on surface and alter the adsorption ratio spatial distribution, conformation, and surface binding affinity of different proteins 114 . As the dimensions of proteins are the nanometer range, nanoscale topographies are thought to influence proteins, whereas micrometer sized topographic surfaces would appear smooth at the protein scale, minimizing the effect of these topographies on protein behavior.…”

Section: Protein Adsorption and Platelet Adhesion On Biomaterials Smentioning

confidence: 99%

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Proteins, platelets, and blood coagulation at biomaterial interfaces

Bauer

Siedlecki

2014

Colloids and Surfaces B: Biointerfaces

325

284

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Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.

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Section: Protein Adsorption and Platelet Adhesion On Biomaterials Smentioning

confidence: 99%

Section: Protein Adsorption and Platelet Adhesion On Biomaterials Smentioning

confidence: 99%

Proteins, platelets, and blood coagulation at biomaterial interfaces

Bauer

Siedlecki

2014

Colloids and Surfaces B: Biointerfaces

325

284

View full text Add to dashboard Cite

show abstract

“…Several studies report that the blood compatibility of a biomaterial can be altered by modifying its surface wettability and topography [21,22,23]. Plasma treatment is a widely used method to create stochastic nanostructures and to modify the surface roughness of Parylene-C [24,25,26] and other biomaterials [27,28].…”

Section: Resultsmentioning

confidence: 99%

Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants

et al. 2018

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This paper investigates the effects on the blood compatibility of surface nanostructuring of Parylene-C coating. The proposed technique, based on the consecutive use of O2 and SF6 plasma, alters the surface roughness and enhances the intrinsic hydrophobicity of Parylene-C. The degree of hydrophobicity of the prepared surface can be precisely controlled by opportunely adjusting the plasma exposure times. Static contact angle measurements, performed on treated Parylene-C, showed a maximum contact angle of 158°. The nanostructured Parylene-C retained its hydrophobicity up to 45 days, when stored in a dry environment. Storing the samples in a body-mimicking solution caused the contact angle to progressively decrease. However, at the end of the measurement, the plasma treated surfaces still exhibited a higher hydrophobicity than the untreated counterparts. The proposed treatment improved the performance of the polymer as a water diffusion barrier in a body simulating environment. Modifying the nanotopography of the polymer influences the adsorption of different blood plasma proteins. The adsorption of albumin—a platelet adhesion inhibitor—and of fibrinogen—a platelet adhesion promoter—was studied by fluorescence microscopy. The adsorption capacity increased monotonically with increasing hydrophobicity for both studied proteins. The effect on albumin adsorption was considerably higher than on fibrinogen. Study of the proteins simultaneous adsorption showed that the albumin to fibrinogen adsorbed ratio increases with substrate hydrophobicity, suggesting lower thrombogenicity of the nanostructured surfaces. Animal experiments proved that the treated surfaces did not trigger any blood clot or thrombus formation when directly exposed to the arterial blood flow. The findings above, together with the exceptional mechanical and insulation properties of Parylene-C, support its use for packaging implants chronically exposed to the blood flow.

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“…Nanostructured surfaces have attracted big attention owing to their unique physical, chemical, and structural properties, including enormously high surface area, quantum confinement, and interaction with light (Hoheisel et al, 2010;Parker and Townley, 2007;Tawfick et al, 2012;VoDinh et al, 2005). Not surprisingly, nanoparticles have found widespread use in proteomics applications that can be summarized into three basic areas: (a) scaffold for protein biosensing, (b) sample purification and enrichment tool, and (c) substrate for mass spectrometry analysis (Luong- Van et al, 2013). These diverse uses enhance the efficiencies of several proteomics applications, including ELISA and mass spectrometry-related techniques, as will be discussed.…”

Section: Nanostructured Surfacesmentioning

confidence: 99%

Post-Genomics Nanotechnology Is Gaining Momentum: Nanoproteomics and Applications in Life Sciences

Kobeissy

Gülbakan

Alawieh

et al. 2014

OMICS: A Journal of Integrative Biology

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The post-genomics era has brought about new Omics biotechnologies, such as proteomics and metabolomics, as well as their novel applications to personal genomics and the quantified self. These advances are now also catalyzing other and newer post-genomics innovations, leading to convergences between Omics and nanotechnology. In this work, we systematically contextualize and exemplify an emerging strand of post-genomics life sciences, namely, nanoproteomics and its applications in health and integrative biological systems. Nanotechnology has been utilized as a complementary component to revolutionize proteomics through different kinds of nanotechnology applications, including nanoporous structures, functionalized nanoparticles, quantum dots, and polymeric nanostructures. Those applications, though still in their infancy, have led to several highly sensitive diagnostics and new methods of drug delivery and targeted therapy for clinical use. The present article differs from previous analyses of nanoproteomics in that it offers an in-depth and comparative evaluation of the attendant biotechnology portfolio and their applications as seen through the lens of post-genomics life sciences and biomedicine. These include: (1) immunosensors for inflammatory, pathogenic, and autoimmune markers for infectious and autoimmune diseases, (2) amplified immunoassays for detection of cancer biomarkers, and (3) methods for targeted therapy and automatically adjusted drug delivery such as in experimental stroke and brain injury studies. As nanoproteomics becomes available both to the clinician at the bedside and the citizens who are increasingly interested in access to novel post-genomics diagnostics through initiatives such as the quantified self, we anticipate further breakthroughs in personalized and targeted medicine.

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Review: Micro- and nanostructured surface engineering for biomedical applications

Abstract: Abstract

Cited by 74 publications

References 71 publications

Proteins, platelets, and blood coagulation at biomaterial interfaces

Proteins, platelets, and blood coagulation at biomaterial interfaces

Surface Nanostructuring of Parylene-C Coatings for Blood Contacting Implants

Post-Genomics Nanotechnology Is Gaining Momentum: Nanoproteomics and Applications in Life Sciences

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