Nano-materials were utilized as therapeutics and diagnostics agents in the
context of human medicine. However, the application of nanoparticles in the field of
livestock animals is still at a nascent stage. The proper utilization of nanoparticles in
livestock sciences, such as improvement in milk production, diagnosis of varied
diseases, delivery of nutrients and/or in their reproduction, offers prospective outcomes
which have direct implications to meet the ever-growing human populations. Further,
with the advent of high throughput omics technologies, noteworthy development in the
past decades has paved the way to advanced systems biology area. The high throughput
data handling from diverse omics methodologies and making a holistic interpretation
posed a challenge, moreover, to connect the dots and present a larger picture of the
intricate network level data, systems biology comes to the rescue. The design and
advancement in different algorithms of systems biology tools seldom help one to
integrate multi-layered data. Systems biology is applied to livestock animals and
poultry for their overall development and/or risk assessment for their diseases. In this
chapter, we discussed the implementation of nanobiotechnology and systems biology
approaches to livestock animals. We illustrated a few examples of how the application
of nanotech and systems biology improved some desired qualities in livestock. This
chapter summarizes the ongoing research and efforts of different groups, along with the
future prospects of innovative technologies in the area of nanotech and systems
biology.