Review of Methods to Study Gene Expression Regulation Applied to Asthma

Garcı́a-Sánchez, Asunción; Garcia, Fabien

doi:10.1007/978-1-4939-3652-6_6

Cited by 2 publications

(3 citation statements)

References 101 publications

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“…Scientists are seeking to improve the detection, prognosis, management, and treatment approaches toward precision oncology to alleviate the burden of this disease on patients, their families, and the healthcare system (52). With the development of high-throughput sequencing technologies, it is possible to assess changes in the genetic and epigenetic profiles of the target genes/genomes and identify potential molecular biomarkers for OC (21,(53)(54)(55)(56).…”

Section: Discussionmentioning

confidence: 99%

Klotho promoter methylation status and its prognostic value in ovarian cancer

et al. 2021

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Among all gynecological cancers, ovarian cancer (OC) is one of the deadliest types of cancer worldwide. Epigenetic silencing of some genes has been reported to be associated with OC. In this context, Klotho (KL) gene methylation is a promising biomarker for OC. The present study aimed to investigate the methylation profiles of KL and assess its prognostic value. A total of 63 formalin-fixed paraffin-embedded tissue samples from patients with primary OC were collected and analyzed in the present study. The methylation profiles of KL were assessed by performing DNA bisulfate treatment followed by DNA promoter methylation analysis using the MethyLight assay. The results revealed KL promoter hypermethylation in 62% of the OC cohort. Additionally, significant associations were observed between KL methylation profiles and tumor subtype (P<0.0001) and tumor site (P=0.039). Furthermore, Kaplan-Meier analysis revealed that a worse disease-specific survival was significantly associated with hypermethylated KL (P=0.03, log-rank; hazard ration, 0.58; 95% confidence interval (CI), 0.26-0.90). Cox regression multivariate analysis indicated that KL promoter methylation was an independent OC prognostic indicator (P=0.029). The current study suggested that KL may be a novel biomarker to predict prognosis in patients with OC, since patients with higher KL promoter methylation were more likely to have a poor prognosis and would therefore require frequent follow-up and integrative personalized therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Klotho promoter methylation status and its prognostic value in ovarian cancer

et al. 2021

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“…Therefore, the manner in which gene information is expressed has become an important scientific topic. Gene expression is defined as a process through which the information encoded in a gene is used to direct the synthesis of a functional gene product (4). As a process, it may explain why organisms containing mostly the same DNA exhibit different cell types and functions (5).…”

Section: Introductionmentioning

confidence: 99%

“…Regulating gene expression is crucial in living organisms (7). Gene regulation is essential in cellular differentiation in multicellular organisms, since it can contribute to the function and the structure of a specific cell, and is an integral part of organism development (4).…”

Section: Introductionmentioning

confidence: 99%

Transcription factors and evolution: An integral part of gene expression (Review)

et al. 2020

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Gene expression is a complex process that is essential to living organisms. Gene expression plays the important role of converting information that is encoded in a gene into a functional product. The primary regulators of gene expression are transcription factors (TFs). TFs are proteins that can bind specific DNA sequences and regulate gene expression. Their evolution is influenced by a large number of factors, including epigenetic mechanisms, gene regulatory elements and molecular cofactors. These molecular mediators, along with transcription factors, form a network that governs gene expression. Elucidating the mechanisms through which TFs have evolved and how they influence the evolution of other regulatory molecules can provide information on organism evolution and on the development of phenotypic variations. The aim of this review article was to provide a summary of the current literature on transcription factor evolution, function and how such evolution has played an important role in the emergence of complex organisms. Contents

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Review of Methods to Study Gene Expression Regulation Applied to Asthma

Cited by 2 publications

References 101 publications

Klotho promoter methylation status and its prognostic value in ovarian cancer

Klotho promoter methylation status and its prognostic value in ovarian cancer

Transcription factors and evolution: An integral part of gene expression (Review)

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