Review on Characterization, Properties, and Analytical Methods of Cefepime

Abstract

Infection is one of the most important reasons for the increase in the number of deaths worldwide; it can be a bacterial or viral infection. As a result, there are many effective drugs against this infection, especially bacterial ones. Cefepime (CP) is one of the fourth generations of cephalosporins and is distinguished from others in that it can kill both positive and negative bacteria. Therefore, this study focused on the chemical properties of the drug, its uses, and its stability against bacteria. All analysis methods for this drug in pharmaceutical preparations, blood, or plasma were also presented. One of the important problems in these methods is using toxic solvents, which poses a danger to society and the environment. The presentation of these solvents will allow companies to manufacture and use more effective and less toxic solvents.

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“…Its efficacy against gramnegative bacteria surpasses that of second and third-generation cephalosporins. [49] The primary mechanism of action for CFP involves binding to the penicillin-binding protein target on bacterial cell walls, thereby disrupting peptidoglycan synthesis and leading to bacterial spheroid formation and filamentous body development followed by dissolution and breakdown. Current experimental evidence demonstrates that compared to thirdgeneration cephalosporin drugs, CFP significantly reduces bacterial resistance and mutation rates, making it an ideal candidate as a new antibacterial agent.…”