Review on the Influence of Stress on Immune Mediators, Neuropeptides and Hormones with Relevance for Inflammatory Bowel Disease

Niess, Jan Hendrik; Mönnikes, Hubert; Dignaß, Axel; Klapp, Burghard F.; Arck, Petra C.

doi:10.1159/000064933

Cited by 36 publications

(27 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[158][159][160] (Table 1). In addition, although there is debate regarding the precise pathophysiological classification of these syndromes, a blunted HPA axis has also been show in fibromyalgia, [161][162][163][164] irritable bowel syndrome 165,166 and chronic fatigue syndrome. 163,[167][168][169][170][171] Disruption of the HPA axis or glucocorticoid response at different levels can predispose to enhanced susceptibility to autoimmune and inflammatory disease.…”

Section: Neuroendocrine Dysregulations In Autoimmune Diseasesmentioning

confidence: 99%

Brain-immune interactions and disease susceptibility

2005

View full text Add to dashboard Cite

Many studies have established the routes by which the immune and central nervous (CNS) systems communicate. This network of connections permits the CNS to regulate the immune system through both neuroendocrine and neuronal pathways. In turn, the immune system signals the CNS through neuronal and humoral routes, via immune mediators and cytokines. This regulatory system between the immune system and CNS plays an important role in susceptibility and resistance to autoimmune, inflammatory, infectious and allergic diseases. This review focuses on the regulation of the immune system via the neuroendocrine system, and underlines the link between neuroendocrine dysregulation and development of major depressive disorders, autoimmune diseases and osteoporosis.

show abstract

Section: Neuroendocrine Dysregulations In Autoimmune Diseasesmentioning

confidence: 99%

Brain-immune interactions and disease susceptibility

2005

View full text Add to dashboard Cite

show abstract

“…In general terms, CD is characterized by inflammation associated with a Th1 response, [11][12][13] while UC is based on a Th2 inflammatory response. 12,14,15 More recently, the regulatory role of the neuroenteric immune axis in intestinal inflammation is gaining recognition. 16 -18 The mechanism by which the neuroendocrine system communicates with the immune system, creating a "neuro-immune dialogue," is through the release of cytokines and neuropeptides to end organ receptors.…”

Section: Immune System and The Enteric Nervous Systemmentioning

confidence: 99%

“…21,22 Inflammatory cells are located in the lamina propria of the gut, in close contact with enteric nerves, demonstrating an anatomical connection between enteric nerves and inflammatory cells. 15 Evidence of peripheral nerve fibers showing close anatomical association and functional communication with immune cells has not only been documented for lymphoid organs, but also for tertiary sites like mucosal surfaces. Neuroimmune communication is also facilitated via enteroglia, which are abundant and in close proximity to nerves, immune cells, and blood capillaries, enabling them to act as immunomodulatory cells in the ENS.…”

Section: Immune System and The Enteric Nervous Systemmentioning

confidence: 99%

Role of neuropeptides in inflammatory bowel disease

Gross

Pothoulakis

2007

Inflammatory Bowel Diseases

149

128

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a chronic, relapsing condition involving complex interactions between genes and the environment. The mechanisms triggering the initial attack and relapses, however, are not well understood. In the past several years the enteric nervous system (ENS) has been implicated in the pathophysiology of IBD. Both the ENS and the central nervous system (CNS) can amplify or modulate aspects of intestinal inflammation through secretion of neuropeptides that serve as a link between the ENS and CNS. Neuropeptides are defined as any peptide released from the nervous system that serves as an intercellular signaling molecule. Neuropeptides thought to play a potentially key role in IBD include substance P, corticotropin-releasing hormone, neurotensin, vasoactive intestinal peptide, mu-opioid receptor agonists, and galanin. This review focuses on the role of these neuropeptides in the pathophysiology of IBD and discusses the cell types and mechanisms involved in this process. The available evidence that neuropeptide blockade may be considered a therapeutic approach in both Crohn's disease and ulcerative colitis will also be discussed.

show abstract

“…As a matter of fact, the bi-directional communication between the immune and neuroendocrine systems plays a pivotal role in modulating the adequate response of the hypothalamic-pituitary-adrenal (HPA) axis to stimulatory influences of peptides and to stress-related mediators [1,2] . The ex-istence of interactions between emotional or psychopathological disorders and allergic and/or chronic diseases such as asthma is well established [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Effects of Stress and Neuropeptides on Airway Responses in Ovalbumin-Sensitized Rats

Portela¹,

Leick-Maldonado

Kasahara

et al. 2007

Neuroimmunomodulation

View full text Add to dashboard Cite

Objective: The aim of this study was to investigate the influence of stress and neuropeptides on airway responses in ovalbumin (OVA)-sensitized rats. Methods: Three experimental conditions were employed: neonatal capsaicin treatment, foot shock stress and OVA sensitization. For neuropeptide depletion, male Wistar rats were neonatally treated with capsaicin (50 mg/kg) or with control solution 2 days after birth. Ninety days later, they were injected with OVA and aluminum hydroxide (ED0) or no injection. Thereafter, rats of the stressed groups were individually placed in a shuttle box where they received 50 mild escapable foot shocks/day; the stressful stimuli were repeated until ED14, when the animals received OVA aerosol. Pulmonary mechanic function was measured before and after OVA challenge in anesthetized and mechanically ventilated rats. Results: Data on ultrasonic vocalizations and corticosterone showed high levels of anxiety in stressed animals. As expected, a significant increment in airway elastance and resistance after the OVA challenge was found in sensitized rats compared to non-sensitized ones. Capsaicin treatment decreased the values of elastance in sensitized and non-stressed rats; however, after the OVA challenge, elastance was increased in stressed animals. No differences were found in the levels of resistance among sensitized and non-stressed rats; however, a reduced increment in resistance was verified in capsaicin-treated, stressed animals. Conclusions: Our results suggest that neurokinin depletion and stress may affect smooth muscle tonus around the airways during an anaphylactic reaction. These data suggest that stress and neuropeptides play a significant role in pulmonary function in OVA-sensitized rats.

show abstract

Review on the Influence of Stress on Immune Mediators, Neuropeptides and Hormones with Relevance for Inflammatory Bowel Disease

Cited by 36 publications

References 64 publications

Brain-immune interactions and disease susceptibility

Brain-immune interactions and disease susceptibility

Role of neuropeptides in inflammatory bowel disease

Effects of Stress and Neuropeptides on Airway Responses in Ovalbumin-Sensitized Rats

Contact Info

Product

Resources

About