Review on the Progress in the Synthesis of Antihistamines and Promethazine

Abstract

In recent years, the development of antihistamines has become a popular research project and is still emphasized to the status of the treatment of allergic diseases. Many companies at home and abroad are working to develop better varieties to seize the pharmaceutical market. Because of antihistamine drugs plays an important role in the treatment of allergic diseases, are allergic rhinitis, urticaria, atomic dermatitis and other first-line drugs, so the size of the market is very considerable. As an antihistamine promethazine, the superiority of its low cost, as the use of veterinary drugs with new drug incomparable. This article comprehensively analyzed the effects of various antihistamines and the principle of their antihistamines and reviewed the synthesis routes of promethazine hydrochloride and its upstream product phenothiazine.