Review on β-cyclodextrin inclusion complex based chemosensors for heavy metals

Sivakumar, K.; Parinamachivayam, G.

doi:10.1007/s10847-022-01153-2

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…The development of ERY–cyclodextrin complexes has been reported to be a promising path towards resolving a series of issues which are aroused in the formulation of ERY, such as improving solubility, reducing degradation and enhancing bioavailability, while reducing the risk of toxic effects. Among cyclodextrines, β–CD is the most frequently used due to its low price and lack of toxicity, in addition to the fact that it is recognized by GRAS as being safe for use in the food industry [ 104 ].…”

Section: Ery–cyclodextrin Complexesmentioning

confidence: 99%

Erythromycin Formulations—A Journey to Advanced Drug Delivery

2022

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Erythromycin (ERY) is a macrolide compound with a broad antimicrobial spectrum which is currently being used to treat a large number of bacterial infections affecting the skin, respiratory tract, intestines, bones and other systems, proving great value from a clinical point of view. It became popular immediately after its discovery in 1952, due to its therapeutic effect against pathogens resistant to other drugs. Despite this major advantage, ERY exhibits several drawbacks, raising serious clinical challenges. Among them, the very low solubility in water and instability under acidic conditions cause a limited efficacy and bioavailability. Apart from this, higher doses promote drug resistance and undesirable effects. In order to overcome these disadvantages, during the past decades, a large variety of ERY formulations, including nanoparticles, have emerged. Despite the interest in ERY-(nano)formulations, a review on them is lacking. Therefore, this work was aimed at reviewing all efforts made to encapsulate ERY in formulations of various chemical compositions, sizes and morphologies. In addition, their preparation/synthesis, physico-chemical properties and performances were carefully analysed. Limitations of these studies, particularly the quantification of ERY, are discussed as well.

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Section: Ery–cyclodextrin Complexesmentioning

confidence: 99%

Erythromycin Formulations—A Journey to Advanced Drug Delivery

2022

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“…In recent years, CDs have received much attention from the scientific community in a wider variety of applicative fields: in cosmetics [9][10][11] and in the food industry for odor and taste control [12][13][14][15][16]; in the environmental sector for heavy metal and pollutant removal [17][18][19][20][21][22]; and in the chemical/pharmaceutical sector as Drug Delivery Systems (DDS), i.e., high-performance carrier materials to deliver an established amount of drug to the targeted site within a specific period of time [6,[23][24][25][26][27][28]. In the last decade, many computational works have been conducted aiming at an atomistic interpretation of the inclusion and release processes for several different guest molecules [29][30][31][32][33][34][35][36], such as amino acids [37][38][39], vitamins [40], unsaturated acids [41], and antioxidants molecules [42].…”

Section: Introductionmentioning

confidence: 99%

Exploration of the Conformational Scenario for α-, β-, and γ-Cyclodextrins in Dry and Wet Conditions, from Monomers to Crystal Structures: A Quantum-Mechanical Study

Pantaleone,

Gho,

Ferrero

et al. 2023

IJMS

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Cyclodextrins (CDs) constitute a class of cyclic oligosaccharides that are well recognized and largely applied in the drug delivery field, thanks to their biocompatibility, low cost, and the possibility to be derivatized in order to tune and optimize the complexation/release of the specific drug. The conformational flexibility of these systems is one of their key properties and requires a cost-effective methodology to be studied by combining the accuracy of results with the possibility of exploring a large set of conformations. In the present paper, we have explored the conformational potential energy surface of the monomers and dimers of α-, β-, and γ-cyclodextrins (i.e., 6, 7, and 8 monomeric units, respectively) by means of fast but accurate semiempirical methods, which are then refined by state-of-the-art DFT functionals. Moreover, the crystal structure is considered for a more suitable comparison with the IR spectrum experimentally recorded. Calculations are carried out in the gas phase and in water environments, applying both implicit and explicit treatments. We show that the conformation of the studied molecules changes from the gas phase to the water, even if treated implicitly, thus modifying their complexation capability.

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