Review: Physicochemical Structure Effects on Metal Oxide Nanoparticulate Cytotoxicity

Chusuei, Charles C.; Wu, Chi-Heng; Mallavarapu, Shravan; Hou, Fang; Hsu, Chen-Ming; Aronstam, Robert S.; Huang, Yue-Wern

doi:10.1021/bk-2015-1215.ch008

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…The XPS spectrum of Zn 2p orbital in Figure 2C shows a doublet separation of 2p3/2 and 2p1/2 orbitals at 1045.1 and 1022.4 eV is 22.7 eV, matching the literature values for ZnO [40,41]. The oxidation state for pure metal oxide O, expected at ~530 eV for ZnO NPs [34,35,42], is greatly attenuated by adsorbed OH overlayers and not readily resolved. The greatly attenuated O 1s metal oxide oxidation state signal is also consistent with the low atomic % Zn 2p observed, that is, the OH overlayers also attenuate the ZnO signal.…”

Section: Resultssupporting

confidence: 73%

“…TEM was carried out using a Hitachi H-7650 microscope operated at 100 kV, applying the colloidal samples to a 200-mesh copper grids. The procedure of isoelectric point measurements, involving pH measurements with a spear-tipped electrode, have been described elsewhere for experiments involving carbon nanomaterial composites [30][31][32][33][34][35]. Briefly, pH solutions varying in values from 1 to 12 were prepared, to which 2.0 mg of the solid material were introduced.…”

Section: Characterizationmentioning

confidence: 99%

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Raman Spectroscopy as an Assay to Disentangle Zinc Oxide Carbon Nanotube Composites for Optimized Uric Acid Detection

et al. 2018

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Refluxed zinc oxide (ZnO) nanoparticles (NPs) were prepared and attached to carboxylic acid functionalized multi-walled carbon nanotubes (COOH-MWNTs) via sonication. Practical optimization of electrocatalysts using sonication to disentangle a carbon nanotube composite for monitoring uric acid (UA) is shown. Monitoring UA is important for the management of medical disorders. Selection of sonication time is a crucial step in producing the desired composite. We report, for the first time, the practical use of Raman spectroscopy to tune the sonication involved in tethering ZnO NPs to the multi-walled carbon nanotube (MWNT) surface. Maximum current for detecting UA, using chronoamperometry and cyclic voltammetry, correlated with the highest sp2-hybridized carbon signal, as seen in the integrated Raman G band peak areas denoting maximum COOH-MWNT disentanglement. An array of ZnO/COOH-MWNT composites were prepared ranging from 60 to 240 min sonication times. Optimum sonication (150 min) corresponded with both maximum measured current and MWNT disentanglement. The sensor was able to quantitatively and selectively measure UA at clinically relevant concentrations (100–900 μM) with rapid current response time (< 5 s).

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Section: Resultssupporting

confidence: 73%

Section: Characterizationmentioning

confidence: 99%

Raman Spectroscopy as an Assay to Disentangle Zinc Oxide Carbon Nanotube Composites for Optimized Uric Acid Detection

et al. 2018

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Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles

et al. 2018

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Sono-Synthesis Approach Improves Anticancer Activity of Zno Nanoparticles: Reactive Oxygen Species Depletion for Killing Human Osteosarcoma Cells

Parsa

Entezari

Meshkini

2021

Nanomedicine (Lond.)

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Aim: To investigate the effect of ultrasound during the synthesis of ZnO nanoparticles (NPs) on their anticancer activity. Materials & methods: ZnO NPs were synthesized in the presence and absence of ultrasonic irradiation. Biological tests were performed on human osteosarcoma cancer cells (Saos-2). Results: The sono-synthesized sample indicated higher cytotoxicity than the conventional one. (IC50 = 16.48 ± 0.41 μg/ml for sonochemical ZnO; 26.96 ± 0.33 μg/ml for conventional ZnO). Both sonochemical and conventional samples acted like antioxidants and reduced intracellular reactive oxygen species level. This reduction was more significant in cells treated with the sono-synthesized sample. The sono-synthesized ZnO NPs showed more tumor selectivity than the conventional sample. Conclusion: Sono-synthesis of ZnO NPs by a bath sonicator could improve their anticancer activity.

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Review: Physicochemical Structure Effects on Metal Oxide Nanoparticulate Cytotoxicity

Cited by 3 publications

References 45 publications

Raman Spectroscopy as an Assay to Disentangle Zinc Oxide Carbon Nanotube Composites for Optimized Uric Acid Detection

Raman Spectroscopy as an Assay to Disentangle Zinc Oxide Carbon Nanotube Composites for Optimized Uric Acid Detection

Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles

Sono-Synthesis Approach Improves Anticancer Activity of Zno Nanoparticles: Reactive Oxygen Species Depletion for Killing Human Osteosarcoma Cells

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