2012
DOI: 10.1182/blood-2012-03-420489
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Revised International Prognostic Scoring System for Myelodysplastic Syndromes

Abstract: AbstractThe International Prognostic Scoring Sytem (IPSS) is an important standard for ssessing prognosis of primary untreated adult patients with myelodysplastic syndromes (MDS). To refine the IPSS, MDS patient databases from international institutions were coalesced to assemble a much larger combined database (Revised-IPSS [IPSS-R], n = 7012, IPSS, n = 816) for analysis. Multiple statistically weighted clinical features were used to generate a prognostic categorization model.… Show more

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Cited by 2,789 publications
(2,708 citation statements)
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References 45 publications
(73 reference statements)
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“…MDS diagnoses were confirmed by morphological examination according to the 2008 World Health Organization (WHO) classification (Swerdlow et al , 2008). Risk assessment was done according to the Revised International Prognostic Scoring System (IPPS‐R) (Greenberg et al , 2012). In the immunophenotypic assay, normal BM (NBM) from 19 healthy volunteers and BM from 27 AML patients served as negative and positive controls, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…MDS diagnoses were confirmed by morphological examination according to the 2008 World Health Organization (WHO) classification (Swerdlow et al , 2008). Risk assessment was done according to the Revised International Prognostic Scoring System (IPPS‐R) (Greenberg et al , 2012). In the immunophenotypic assay, normal BM (NBM) from 19 healthy volunteers and BM from 27 AML patients served as negative and positive controls, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…The French, American, and British (FAB) classification has been employed in order to classify MDS as low-, intermediate-, or high-risk MDS, according to the International Prognostic Scoring System (IPSS) (4,5). The IPSS is based on certain criteria such as the number of cytopenias, cytogenetic profile, and the percentage of blasts in the bone marrow, and allows the classification of MDS patients into 1 of 4 prognostic categories: low risk, intermediate 1 risk, intermediate 2 risk, and high risk.…”
Section: Methodsmentioning
confidence: 99%
“…Cases were stratified according to the UK Medical Research Council 20 karyotype risk grouping for acute myeloid leukemia. The chronic myelomonocytic leukemia karyotypes were also stratified according to the IPSS scoring system, 21 the new Comprehensive Cytogenetic Scoring System (CCSS) for primary myelodysplastic syndrome, 22 and the recently proposed cytogenetic risk stratification system for chronic myelomonocytic leukemia. 23 The CCSS score was also used along with blood counts and bone marrow blast count to classify the chronic myelomonocytic leukemia cases according to the IPSS-R scoring system.…”
Section: Cytogeneticsmentioning
confidence: 99%
“…In addition, we examined the clinicopathologic and genetic features that were associated with progression to acute myeloid leukemia in a larger group of chronic myelomonocytic leukemia patients, including the Revised International Prognostic Scoring System (IPSS-R) for myelodysplastic syndrome. 17 …”
mentioning
confidence: 99%