Revision arthroplasty: an update

Williams, Deborah; Taylor, Adam Michael; McLardy-Smith, P.

doi:10.1007/s00256-009-0781-z

Cited by 10 publications

(1 citation statement)

References 55 publications

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“…Artificial joint replacement (AJR) is a successful therapy for patients suffering from severe joint disorders; in this regard, the valid life of artificial joint becomes a new issue. An increasing number of patients should perform revision operations in more than a 10‐year follow‐up after AJR (Williams, Taylor, & McLardy‐Smith, 2009). One of the main reasons is periprosthetic osteolysis (PIO), which leads to aseptic loosening.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways

Liao

Feng

Liu

et al. 2020

Journal Cellular Physiology

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Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading to prosthetic loosening is the main cause of why the overactivation of osteoclasts (OCs) plays an important role. The effect of biochanin A (BCA) has been examined in osteoporosis, but no study on the role of BCA in prosthetic loosening osteolysis has been conducted yet. In this study, we utilised enzyme-linked immunosorbent assay, computed tomography imaging, and histological analysis. Results showed that BCA downregulated the secretion levels of tumor necrosis factor-α, interleukin-1α (IL-1α), and IL-1β to suppress inflammatory responses. The secretion levels of receptor-activated nuclear factor-κB ligand, CTX-1, and osteoclast-associated receptor as well as Ti-induced osteolysis were also reduced. BCA effectively inhibited osteoclastogenesis and suppressed hydroxyapatite resorption by downregulating OC-related genes in vitro. Analysis of mechanisms indicated that BCA inhibited the signalling pathways of mitogenactivated protein kinase (P38, extracellular signal-regulated kinase, and c-JUN N-terminal kinase) and nuclear factor-κB (inhibitor κB-α and P65), thereby downregulating the expression of nuclear factor of activated T cell 1 and c-Fos. In conclusion, BCA may be an alternative choice for the prevention of prosthetic loosening caused by OCs.

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Section: Introductionmentioning

confidence: 99%