Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases

Campuzano, Susana; Yáñez‐Sedeño, Paloma; Pingarrón, José M.

doi:10.3390/s21010189

Cited by 14 publications

(5 citation statements)

References 75 publications

(168 reference statements)

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“…Reflecting this key role of cytokines in relation to the intestinal microbiome and derived inflammatory diseases, a large number of electrochemical (bio)sensors have been reported in recent years for the single or multiple determination of interleukins, chemokines and other cytokines in clinical samples [ 45 , 46 ]. However, methods devoted to interleukins directly related to the gut microbiome and IBD disorder are very scarce.…”

Section: Gastrointestinal Microbiomementioning

confidence: 99%

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Sánchez‐Tirado

Agüı́

González‐Cortés

et al. 2023

Sensors

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The study of the human microbiome is a multidisciplinary area ranging from the field of technology to that of personalized medicine. The possibility of using microbiota biomarkers to improve the diagnosis and monitoring of diseases (e.g., cancer), health conditions (e.g., obesity) or relevant processes (e.g., aging) has raised great expectations, also in the field of bioelectroanalytical chemistry. The well-known advantages of electrochemical biosensors—high sensitivity, fast response, and the possibility of miniaturization, together with the potential for new nanomaterials to improve their design and performance—position them as unique tools to provide a better understanding of the entities of the human microbiome and raise the prospect of huge and important developments in the coming years. This review article compiles recent applications of electrochemical (bio)sensors for monitoring microbial metabolites and disease biomarkers related to different types of human microbiome, with a special focus on the gastrointestinal microbiome. Examples of electrochemical devices applied to real samples are critically discussed, as well as challenges to be faced and where future developments are expected to go.

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Section: Gastrointestinal Microbiomementioning

confidence: 99%

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Sánchez‐Tirado

Agüı́

González‐Cortés

et al. 2023

Sensors

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“…Being aware of this key role of cytokines in relation to the intestinal microbiome and the derived inflammatory diseases, a large number of electrochemical (bio)sensors have been reported in recent years for the single or multiple determination of interleukins, chemokines and other cytokines in clinical samples [43,44]. However, methods devoted to interleukins directly related to the gut microbiome and IBD disorder are very scarce.…”

Section: Gastrointestinal Microbiomementioning

confidence: 99%

Electrochemical (Bio)Sensing Devices for Human Microbiome Related Biomarkers

Sánchez‐Tirado¹,

Agüı́²,

González‐Cortés³

et al. 2022

Preprint

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The study of the human microbiome is a multidisciplinary area that affects from the field of technology to that of personalized medicine. The possibility of using microbiota biomarkers for the improvement in the diagnosis and monitoring of diseases (e.g. cancer), health conditions (e.g. obesity) or clinical parameters (e.g. ageing) has aroused great expectations, also in the scope of bio-electroanalytical chemistry. The well-known advantages of electrochemical transduction: high sensitivity, rapid response and possibility of miniaturization, together with the potential of new nanomaterials to improve both the design of electrode platforms and the performance of the resulting electrochemical biosensors make presumably a huge development in the next few years providing a better understanding of human microbiome entities. In this review article, the recent applications of electrochemical (bio)sensors for monitoring microbial metabolites and biomarkers of diseases related to different types of the human microbiome, with a special focus on the gastrointestinal microbiome, are reviewed. Examples of electrochemical devices applied to real samples are critically discussed as well as the challenges and prospects to be faced.

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“…With these many functions, cytokines encompass an assembly of biomolecules including inflammatory cytokines (interleukins (ILs), the family of tumor necrosis factors and adipokines), acute-phase reactants, chemokines, interferons, mesenchymal growth factors, colony-stimulating factors, and nerve growth factors [58][59][60].…”

Section: Immunologic Factorsmentioning

confidence: 99%

Loneliness: An Immunometabolic Syndrome

Pourriyahi

Rezaei

Saghazadeh

et al. 2021

IJERPH

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Loneliness has been defined as an agonizing encounter, experienced when the need for human intimacy is not met adequately, or when a person’s social network does not match their preference, either in number or attributes. This definition helps us realize that the cause of loneliness is not merely being alone, but rather not being in the company we desire. With loneliness being introduced as a measurable, distinct psychological experience, it has been found to be associated with poor health behaviors, heightened stress response, and inadequate physiological repairing activity. With these three major pathways of pathogenesis, loneliness can do much harm; as it impacts both immune and metabolic regulation, altering the levels of inflammatory cytokines, growth factors, acute-phase reactants, chemokines, immunoglobulins, antibody response against viruses and vaccines, and immune cell activity; and affecting stress circuitry, glycemic control, lipid metabolism, body composition, metabolic syndrome, cardiovascular function, cognitive function and mental health, respectively. Taken together, there are too many immunologic and metabolic manifestations associated with the construct of loneliness, and with previous literature showcasing loneliness as a distinct psychological experience and a health determinant, we propose that loneliness, in and of itself, is not just a psychosocial phenomenon. It is also an all-encompassing complex of systemic alterations that occur with it, expanding it into a syndrome of events, linked through a shared network of immunometabolic pathology. This review aims to portray a detailed picture of loneliness as an “immunometabolic syndrome”, with its multifaceted pathology.

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Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases

Cited by 14 publications

References 75 publications

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Electrochemical (Bio)Sensing Devices for Human Microbiome Related Biomarkers

Loneliness: An Immunometabolic Syndrome

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