Revisiting the link between PGD and BOS in lung transplantation: highlighting the role of tregs

Shigemura, Norihisa

doi:10.1111/tri.13595

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Furthermore, PGD was associated with an increased mortality rate at one year [OR 1.7 (95% CI 1.2, 2.3), p = .0001] ( 33 ). PGD has also been linked with a higher risk of CLAD and poorer long-term outcomes ( 34 , 35 ).…”

Section: Pre-existing Lra Development and Their Role In Pgdmentioning

confidence: 99%

The role of lung-restricted autoantibodies in the development of primary and chronic graft dysfunction

Yang,

Lecuona,

et al. 2023

Front. Transplant.

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Lung transplantation is a life-saving treatment for both chronic end-stage lung diseases and acute respiratory distress syndrome, including those caused by infectious agents like COVID-19. Despite its increasing utilization, outcomes post-lung transplantation are worse than other solid organ transplants. Primary graft dysfunction (PGD)—a condition affecting more than half of the recipients post-transplantation—is the chief risk factor for post-operative mortality, transplant-associated multi-organ dysfunction, and long-term graft loss due to chronic rejection. While donor-specific antibodies targeting allogenic human leukocyte antigens have been linked to transplant rejection, the role of recipient's pre-existing immunoglobulin G autoantibodies against lung-restricted self-antigens (LRA), like collagen type V and k-alpha1 tubulin, is less understood in the context of lung transplantation. Recent studies have found an increased risk of PGD development in lung transplant recipients with LRA. This review will synthesize past and ongoing research—utilizing both mouse models and human subjects—aimed at unraveling the mechanisms by which LRA heightens the risk of PGD. Furthermore, it will explore prospective approaches designed to mitigate the impact of LRA on lung transplant patients.

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Section: Pre-existing Lra Development and Their Role In Pgdmentioning

confidence: 99%

The role of lung-restricted autoantibodies in the development of primary and chronic graft dysfunction

Yang,

Lecuona,

et al. 2023

Front. Transplant.

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IL-17A neutralization fails to attenuate airway remodeling and potentiates a proinflammatory lung microenvironment in diacetyl-exposed rats

House,

Kim,

Chalupa

et al. 2023

American Journal of Physiology-Lung Cellular and Molecular Phys

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Interleukin-17A (IL-17A) neutralization has shown benefit previously in preclinical models of transplant-associated bronchiolitis obliterans (BO), yet it remains unknown whether IL-17A neutralization has similar benefit for other forms of BO. Here, IL-17A neutralization fails to prevent severe airway remodeling in rats exposed repetitively to the flavoring chemical diacetyl, and instead, promotes a proinflammatory microenvironment with increased expression of TNF-α, IL-1β, and NF-κB within the lung.

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Revisiting the link between PGD and BOS in lung transplantation: highlighting the role of tregs

Cited by 2 publications

References 12 publications

The role of lung-restricted autoantibodies in the development of primary and chronic graft dysfunction

The role of lung-restricted autoantibodies in the development of primary and chronic graft dysfunction

IL-17A neutralization fails to attenuate airway remodeling and potentiates a proinflammatory lung microenvironment in diacetyl-exposed rats

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