Revisiting the Pneumocystis host specificity paradigm and transmission ecology in wild Southeast Asian rodents

Latinne, Alice; Chen, Hsuan Wien; Kuo, Chun-Hung; Lorica, Renee P.; Singleton, Grant R.; Stuart, Alex; Malbas, Fedelino F.; Demanche, Christine; Chabé, Magali; Michaux, Johan; Morand, Sergé

doi:10.1016/j.meegid.2021.104978

Cited by 7 publications

(22 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disparity of actual versus sampled intrageneric mammal diversity is likely creating a sampling artifact, inflating the inferred specificity of Pneumocystis in prior analyses [ 22 ]. Assumptions of strict host specificity based on experiments in which Pneumocystis could not be transmitted between laboratory mice and laboratory rats are now being challenged by the further sampling of the genera Mus and Rattus [ 6 , 20 , 23 ]. Thus, far the evidence for multi-host Pneumocystis , in this and other work [ 23 ], is strongest in rodent hosts, which may be indicative of less strict host specificity among rapidly diversifying or closely related hosts [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Assumptions of strict host specificity based on experiments in which Pneumocystis could not be transmitted between laboratory mice and laboratory rats are now being challenged by the further sampling of the genera Mus and Rattus [ 6 , 20 , 23 ]. Thus, far the evidence for multi-host Pneumocystis , in this and other work [ 23 ], is strongest in rodent hosts, which may be indicative of less strict host specificity among rapidly diversifying or closely related hosts [ 22 ]. Such a question should be addressed by further research when sampling is improved.…”

Section: Discussionmentioning

confidence: 99%

“…However, the true degree of host specificity in this genus has not been sufficiently tested, and evidence suggests some Pneumocystis species may be shared by closely related hosts, such as within mammalian genera [ 17 , 18 , 19 , 20 ]. This evidence has led researchers to reassess assumptions of single host specificity [ 21 , 22 , 23 ]. Unfortunately, we still have little direct evidence.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the potential diversity within Pneumocystis , species discovery in the genus has been slow, exemplified by the fact that the recently named Pneumocystis canis collected from domestic dogs [ 14 ] is the first described species since the rabbit-inhabiting Pneumocystis orcytolagi in 2006 [ 13 ]. Meanwhile, several papers have been published describing genetic sequences of novel Pneumocystis lineages taken from diverse mammal groups, including primates, bats, and rodents, with mitochondrial genetic divergence among these lineages commonly falling between 10 and 30% [ 20 , 23 , 24 , 25 ]. None of the novel lineages from these publications have been described as new species.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Predicting Species Boundaries and Assessing Undescribed Diversity in Pneumocystis, an Obligate Lung Symbiont

Babb-Biernacki

Esselstyn

Doyle

2022

JoF

View full text Add to dashboard Cite

Far more biodiversity exists in Fungi than has been described, or could be described in several lifetimes, given current rates of species discovery. Although this problem is widespread taxonomically, our knowledge of animal-associated fungi is especially lacking. Fungi in the genus Pneumocystis are obligate inhabitants of mammal lungs, and they have been detected in a phylogenetically diverse array of species representing many major mammal lineages. The hypothesis that Pneumocystis cospeciate with their mammalian hosts suggests that thousands of Pneumocystis species may exist, potentially equal to the number of mammal species. However, only six species have been described, and the true correspondence of Pneumocystis diversity to host species boundaries is unclear. Here, we use molecular species delimitation to estimate the boundaries of Pneumocystis species sampled from 55 mammal species representing eight orders. Our results suggest that Pneumocystis species often colonize several closely related mammals, especially those in the same genus. Using the newly estimated ratio of fungal to host diversity, we estimate ≈4600 to 6250 Pneumocystis species inhabit the 6495 currently recognized extant mammal species. Additionally, we review the literature and find that only 240 (~3.7%) mammal species have been screened for Pneumocystis, and many detected Pneumocystis lineages are not represented by any genetic data. Although crude, our findings challenge the dominant perspective of strict specificity of Pneumocystis to their mammal hosts and highlight an abundance of undescribed diversity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Predicting Species Boundaries and Assessing Undescribed Diversity in Pneumocystis, an Obligate Lung Symbiont

Babb-Biernacki

Esselstyn

Doyle

2022

JoF

View full text Add to dashboard Cite

show abstract

“…The fungal genus Pneumocystis encompasses a myriad of species that colonize the lungs of mammals ( 1 ). Each Pneumocystis species is specific to a single mammalian species, although exceptions exist in small mammals ( 2 ). Genome sequencing revealed the obligate parasitism of these fungi because of the absence of many genes required for essential metabolic pathways.…”

Section: Opinion/hypothesismentioning

confidence: 99%

Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species

Hauser

Almeida

Richard

et al. 2022

mBio

View full text Add to dashboard Cite

show abstract

Classes and phyla of the kingdom Fungi

Wijayawardene,

Hyde,

Mikhailov

et al. 2024

Fungal Diversity

View full text Add to dashboard Cite

Fungi are one of the most diverse groups of organisms with an estimated number of species in the range of 2–3 million. The higher-level ranking of fungi has been discussed in the framework of molecular phylogenetics since Hibbett et al., and the definition and the higher ranks (e.g., phyla) of the ‘true fungi’ have been revised in several subsequent publications. Rapid accumulation of novel genomic data and the advancements in phylogenetics now facilitate a robust and precise foundation for the higher-level classification within the kingdom. This study provides an updated classification of the kingdom Fungi, drawing upon a comprehensive phylogenomic analysis of Holomycota, with which we outline well-supported nodes of the fungal tree and explore more contentious groupings. We accept 19 phyla of Fungi, viz. Aphelidiomycota, Ascomycota, Basidiobolomycota, Basidiomycota, Blastocladiomycota, Calcarisporiellomycota, Chytridiomycota, Entomophthoromycota, Entorrhizomycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota, Sanchytriomycota, and Zoopagomycota. In the phylogenies, Caulochytriomycota resides in Chytridiomycota; thus, the former is regarded as a synonym of the latter, while Caulochytriomycetes is viewed as a class in Chytridiomycota. We provide a description of each phylum followed by its classes. A new subphylum, Sanchytriomycotina Karpov is introduced as the only subphylum in Sanchytriomycota. The subclass Pneumocystomycetidae Kirk et al. in Pneumocystomycetes, Ascomycota is invalid and thus validated. Placements of fossil fungi in phyla and classes are also discussed, providing examples.

show abstract

Revisiting the Pneumocystis host specificity paradigm and transmission ecology in wild Southeast Asian rodents

Cited by 7 publications

References 56 publications

Predicting Species Boundaries and Assessing Undescribed Diversity in Pneumocystis, an Obligate Lung Symbiont

Predicting Species Boundaries and Assessing Undescribed Diversity in Pneumocystis, an Obligate Lung Symbiont

Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species

Classes and phyla of the kingdom Fungi

Contact Info

Product

Resources

About