The clinical application of the retrograde postauricular island flap has been widely restricted because of its limited size and high morbidity of venous congestion. Thus, in this article, we introduced a pre-expanded retrograde postauricular island flap to reconstruct the large periorbital defect. A total of 13 patients with periorbital lesions who had undergone the treatment of our flap were enrolled in the study. The whole series of operations was divided into 3 parts, including expander implantation in the postauricular region, a series of expander inflations, and flap transferring, and special incisions were also designed in the procedure. In the end, all the flaps survived without serious complications. The mean size of the harvested flaps was 2.65 times larger than that of our nonexpanded cases. The reconstructed periorbital region showed a functional and aesthetic repair outcome after a follow-up of 3 to 30 months. To conclude, the pre-expanded retrograde postauricular island flap was a safe way to reconstruct a larger periorbital defect.