Motivated by the recent hints of lepton flavor universality violation observed in semileptonic B decays, we analyze how to test flavor and helicity structures of the corresponding amplitudes in view of future data. We show that the general assumption that such non-standard effects are controlled by a U (2)q × U (2) flavor symmetry, minimally broken as in the Standard Model Yukawa sector, leads to stringent predictions on leptonic and semileptonic B decays. Future measurements of R D ( * ) , R K ( * ) , B(Bc,u → ν), B(B → π ν), B(B → π ¯ ), B(B s,d → ¯ ( ) ), as well as various polarization asymmetries inB → D ( * ) τν decays, will allow to prove or falsify this general hypothesis independently of its dynamical origin.