Reward Sensitivity, Decisional Bias, and Metacognitive Deficits in Cocaine Drug Addiction

Balconi, Michela; Finocchiaro, Roberta; Campanella, Salvatore

doi:10.1097/adm.0000000000000065

Cited by 68 publications

(46 citation statements)

References 67 publications

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“…Executive dysfunction (assessed via the Frontal Systems Behavior Scale) (Gjini et al, 2014) and reduced performance on the IGT (Balconi et al, 2014) have been previously reported in iCUD (as compared to HC). Some of these cognitive impairments are ameliorated by significant decreases (>70%) in cocaine use or even recover fully after complete cessation of cocaine use (Vonmoos et al, 2014).…”

Section: Discussionmentioning

confidence: 87%

Prefrontal gray matter volume recovery in treatment-seeking cocaine-addicted individuals: a longitudinal study

et al. 2016

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Deficits in prefrontal cortical (PFC) function have been consistently reported in individuals with cocaine use disorders (iCUD), and have separately been shown to improve with longer-term abstinence. However, it is less clear whether the PFC structural integrity possibly underlying these deficits is also modulated by sustained reduction in drug use in iCUD. Here, T1-weighted magnetic resonance imaging scans were acquired, and performance on a neuropsychological test battery was assessed, in 19 initially abstinent treatment-seeking iCUD, first at baseline and then after six months of significantly reduced or no drug use (follow-up). A comparison cohort of 12 healthy controls was also scanned twice with a similar inter-scan interval. The iCUD showed increased gray matter volume in the left inferior frontal gyrus and bilaterally in the ventromedial prefrontal cortex at follow-up compared to baseline; healthy controls, as expected, showed no changes over this same time period. The iCUD also showed improved decision making and cognitive flexibility, with the latter correlated significantly with the gray matter volume increases in the inferior frontal gyrus. Given its association with improved cognitive function, the longitudinal recovery in cortical gray matter volume, particularly in regions where structure and function are adversely affected by chronic drug use, reflects a quantifiable positive impact of significantly reduced drug use on cortical structural integrity.

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Section: Discussionmentioning

confidence: 87%

Prefrontal gray matter volume recovery in treatment-seeking cocaine-addicted individuals: a longitudinal study

et al. 2016

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“…Alcohol, tobacco, and drug use is associated with high BAS scores (Balconi et al, 2014a; Franken et al, 2006; Johnson et al, 2003; Knyazev, 2004; Yen et al, 2009). The BAS Drive and Fun Seeking subscale scores, in particular, have been shown to be higher in heroin, cocaine, and amphetamine dependent subjects than controls (Franken et al, 2006; Perry et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence

Yamamoto

Banich

Regner

et al. 2017

Drug and Alcohol Dependence

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Behavioral approach, defined as behavior directed toward a reward or novel stimulus, when elevated, may increase one’s vulnerability to substance use disorder. Behavioral approach has been associated with relatively greater left compared to right frontal activity; behavioral inhibition may be associated with relatively greater right compared to left frontal brain activity. We hypothesized that substance dependent individuals (SDI) would have higher behavioral approach than controls and greater prefrontal cortical activity during decision-making involving reward. We hypothesized that behavioral approach would correlate with left frontal activity during decision-making and that the correlation would be stronger in SDI than controls. 31 SDI and 21 controls completed the Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales and performed a decision-making task during fMRI. Orbitofrontal (OFC) and dorsolateral prefrontal activity were correlated with BIS and BAS scores. Compared to controls, SDI had higher BAS Fun Seeking scores (p<0.001) and worse decision-making performance (p=0.004). BAS Fun Seeking correlated with left OFC activity during decision-making across group (r=0.444, p<0.003). The correlation did not differ by group. There was no correlation between BIS and right frontal activity. Left OFC may play a role in reward-related decision-making in substance use disorder especially in individuals with high behavioral approach.

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“…The neural circuits related to the ability to interpret this feedback in health adults include the dorsal and ventral prefrontal cortex (PFC), striatum, anterior cingulate cortex (ACC), nucleus accumbens and insula (Balasubramani et al, 2015, Ernst and Steinhauser, 2015, Hauser et al, 2015, Kohno et al, 2015, Liu et al, 2011, Rao et al, 2014, Tanabe et al, 2013). An impaired ability to learn from outcomes has been demonstrated in individuals with substance dependence disorders (Balconi et al, 2014, Tanabe et al, 2013, Worbe et al, 2014). Studies using the Iowa gambling task (IGT) have identified decreased task performance in substance-dependent individuals, which may indicate deficits in learning from feedback (Balconi et al, 2014, Tanabe et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of outcome on the covariance between risk level and brain activity in adolescents with internet gaming disorder

Yang

Dai

et al. 2016

NeuroImage: Clinical

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Individuals with internet gaming disorder (IGD) often have impaired risky decision-making abilities, and IGD-related functional changes have been observed during neuroimaging studies of decision-making tasks. However, it is still unclear how feedback (outcomes of decision-making) affects the subsequent risky decision-making in individuals with IGD. In this study, twenty-four adolescents with IGD and 24 healthy controls (HCs) were recruited and underwent functional magnetic resonance imaging while performing the balloon analog risk task (BART) to evaluate the effects of prior outcomes on brain activity during subsequent risky decision-making in adolescents with IGD. The covariance between risk level and activation of the bilateral ventral medial prefrontal cortex, left inferior frontal cortex, right ventral striatum (VS), left hippocampus/parahippocampus, right inferior occipital gyrus/fusiform gyrus and right inferior temporal gyrus demonstrated interaction effects of group by outcome (P < 0.05, AlphaSim correction). The regions with interactive effects were defined as ROI, and ROI-based intergroup comparisons showed that the covariance between risk level and brain activation was significantly greater in adolescents with IGD compared with HCs after a negative outcome occurred (P < 0.05). Our results indicated that negative outcomes affected the covariance between risk level and activation of the brain regions related to value estimation (prefrontal cortex), anticipation of rewards (VS), and emotional-related learning (hippocampus/parahippocampus), which may be one of the underlying neural mechanisms of disadvantageous risky decision-making in adolescents with IGD.

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Reward Sensitivity, Decisional Bias, and Metacognitive Deficits in Cocaine Drug Addiction

Abstract: We discuss the likely cognitive, brain, and neurotransmitter contributions to this phenomenon.

Cited by 68 publications

References 67 publications

Prefrontal gray matter volume recovery in treatment-seeking cocaine-addicted individuals: a longitudinal study

Prefrontal gray matter volume recovery in treatment-seeking cocaine-addicted individuals: a longitudinal study

Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence

Effects of outcome on the covariance between risk level and brain activity in adolescents with internet gaming disorder

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