2024
DOI: 10.1101/2024.01.10.574961
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Rgf1 GEF activity toward Rho1 defines a new actin-dependent signal to determine growth sites independently of microtubules and Tea1

Patricia Garcia,
Ruben Celador,
Tomas Edreira
et al.

Abstract: Cellular asymmetry begins with the selection of a discrete point on the cell surface that triggers Rho-GTPases activation and localized assembly of the cytoskeleton to establish new growth zones. The cylindrical shape of fission yeast is organized by microtubules that deliver the landmark Tea1–Tea4 complex at the cell tips to define the growth poles. However, only a fewtea1Δ cells mistaken the direction of growth, indicating that they manage to detect their growth sites. Here we show that Rgf1 (Rho1-GEF) and T… Show more

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