Rhabdoid meningioma lacking malignant features: Report of a rare case with review of literature

Abstract

We reported a case of meningioma with rhabdoid morphology but lacking histological features of malignancy in arising from the spinal cord in a 28-year-old male. The tumor showed light microscopic, immunohistochemical evidence of meningothelial differentiation together with diffuse areas exhibiting rhabdoid morphology. The rhabdoid areas were characterized by cells with large cytoplasmic eosinophilic inclusions and eccentric nuclei. Unlike most cases reported in the literature, this case lacked significant mitotic activity and other atypical features. The diagnostic and prognostic significance of this tumor entity is discussed along with a review of the literature.

Rhabdoid Meningioma Metastases Cervical Lymph Nodes: A Rare Clinical Case Report and Treatment Outcome

“…However, not all of the meningioma patients with rhabdoid displaying malignant characteristics; histological features of malignancy were useful in these cases. 18,19 Immunohistochemical staining may be helpful not only in diagnosis but also in exclusion of other different diagnoses and evaluation of tumor aggressiveness. On immunohistochemistry, immunoprofile of meningioma is a group of diseases with positiveness to EMA, vimentin, and claudin-1.…”

“…However, not all of the meningioma patients with rhabdoid displaying malignant characteristics; histological features of malignancy were useful in these cases. 18 , 19 …”

Bilateral rhabdoid meningioma mimicking glioma: an unusual occurrence

“…Rhabdoid meningiomas were described for the first time in 1998 as an unusual variant with increased proliferative activity. Later, in 2000, these tumors were included in the revised WHO classification of CNS tumors as an aggressive meningioma corresponding to WHO grade III [1], [3]. …”

“…These anaplastic meningiomas represent 1–2% of all meningiomas. They are associated with rapid growth, brain invasion and frequent recurrences [3], [4]. …”

Clinical, Histopathologic and Genetic Features of Rhabdoid Meningiomas

“…First, we performed a deep review of RM cases previously reported in the literature between 1998 and 2021 [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 ]. A total of 305 RM cases were identified, including adults and children or adolescents under the age of 18 years.…”