Rhabdomyolysis and acute kidney injury due to suicide attempt with tramadol: A rare case report

Abstract

Although acute kidney injury (AKI) is a very rare complication of tramadol (TR) poisoning, overdose use in recent years should be considered. We present a 21‐year‐old man with metabolic acidosis, seizures, elevated serum creatine phosphokinase (CPK), creatinine, and rhabdomyolysis due to tramadol poisoning.

Tramadol poisoning and its management and complications: a scoping review

“…Supportive therapy, including hydration and alkalinization of urine with sodium bicarbonate, is essential in patients with rhabdomyolysis and appropriate urinary output. If there is no response to treatment, dialysis is recommended 21 .…”

“…Respiratory depression triggered by TR is rare, with increased frequency in individuals that exhibit CYP2D6 duplication (high metabolizers). Given the considerable variability in CYP2D6 expression across individuals, the analgesic effect of TR exhibits wide-ranging differences among patients 21 . Unlike several other opioids, there have been relatively few reports of TR-induced respiratory depression and apnea published in scientific literature.…”

“…On the other hand, chronic TR use or abuse may cause several adverse effects that include fatigue, dizziness, vertigo, headache, visual disturbances, nausea, vomiting, sweating, dry mouth, constipation, postural hypotension, irregular heartbeats, euphoria, dysphoria, and hallucinations 20 . According to reliable sources, acute kidney injury (AKI) is not a common consequence of TR poisoning, and information regarding its prevalence and treatment is limited, but there have been cases of AKI following TR toxicity in recent years 21 – 23 .…”