Advances in Skeletal Reconstruction Using Bone Morphogenetic Proteins 2002
DOI: 10.1142/9789812706577_0007
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rhBMP-2 and Coral Composite Bone Substitute in Repair of Cranio-Maxillary Bone Defects

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Cited by 8 publications
(9 citation statements)
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“…Hence, we used PGS as a carrier for rhBMP-2. Mao et al 33 reported that at 12 weeks the composite using rhBMP with chitin, coral or xenogenetic cancellous bone was replaced completely by new bone. In our study, the new bone formation with rhBMP/PGS was observed after 8 weeks earlier than previous reports.…”
Section: Discussionmentioning
confidence: 99%
“…Hence, we used PGS as a carrier for rhBMP-2. Mao et al 33 reported that at 12 weeks the composite using rhBMP with chitin, coral or xenogenetic cancellous bone was replaced completely by new bone. In our study, the new bone formation with rhBMP/PGS was observed after 8 weeks earlier than previous reports.…”
Section: Discussionmentioning
confidence: 99%
“…Many materials, such as tricalcium phosphate 9,49,51,59) , polylactic acid polymer 14) , collagen 7,10,44,55) , demineralized bone matrix 14,21,44) , hydroxyapatite 17,24,29,36) , gelatin 18) , fibrin sealant 22) , polylactic-polyglycolic polymer 4,26,31,44,58) , and composites of these materials 19,37,40,60) have been used and evaluated as a BMP carrier for healing of bone defects. Some of the BMP carrier requirements have been satisfied by these materials, but a rapidly resorbable carrier that has the desirable mechanical and plastic properties has yet to be developed.…”
Section: Discussionmentioning
confidence: 99%
“…Various biomaterials have been tested as candidate carriers of BMPs. They include collagen, 10,11 decalcified bone matrix, 10 hyaluronan, 12 hydroxyapatite, 13 tricalcium phosphate, 14‐17 a hydroxyapatite‐collagen composite, 18 polylactic acid polymer, 19 polylactic‐polyglycolic polymer, 10,20 gelatin, 21 fibrin sealant, 22 and composites of these materials 23 . Each carrier material showed various advantages and disadvantages, and it has not yet been determined which of these materials constitutes the ideal carrier system for BMPs.…”
mentioning
confidence: 99%