Rheological behavior of biodegradable N-succinyl chitosan-g-poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release

Bashir, Shahid; Teo, Yin Yin; Ramesh, Sivalingam; Mushtaq, Muhammad

doi:10.1016/j.ijbiomac.2018.05.182

Cited by 49 publications

(34 citation statements)

References 46 publications

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“…The preferred mechanical properties of hydrogels may be attained by incorporating specific polymers, co-monomers, and crosslinkers and by changing the crosslinking degree. A strong gel network can be obtained with increasing the degree of crosslinking [132]. However, too high of a degree of crosslinking will result in low elongation and elasticity with greater brittleness.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

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Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

et al. 2020

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In the present review, we focused on the fundamental concepts of hydrogels—classification, the polymers involved, synthesis methods, types of hydrogels, properties, and applications of the hydrogel. Hydrogels can be synthesized from natural polymers, synthetic polymers, polymerizable synthetic monomers, and a combination of natural and synthetic polymers. Synthesis of hydrogels involves physical, chemical, and hybrid bonding. The bonding is formed via different routes, such as solution casting, solution mixing, bulk polymerization, free radical mechanism, radiation method, and interpenetrating network formation. The synthesized hydrogels have significant properties, such as mechanical strength, biocompatibility, biodegradability, swellability, and stimuli sensitivity. These properties are substantial for electrochemical and biomedical applications. Furthermore, this review emphasizes flexible and self-healable hydrogels as electrolytes for energy storage and energy conversion applications. Insufficient adhesiveness (less interfacial interaction) between electrodes and electrolytes and mechanical strength pose serious challenges, such as delamination of the supercapacitors, batteries, and solar cells. Owing to smart and aqueous hydrogels, robust mechanical strength, adhesiveness, stretchability, strain sensitivity, and self-healability are the critical factors that can identify the reliability and robustness of the energy storage and conversion devices. These devices are highly efficient and convenient for smart, light-weight, foldable electronics and modern pollution-free transportation in the current decade.

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Section: Mechanical Propertiesmentioning

confidence: 99%

“…Frequency-based sinusoidal testing is usually done using a rheometer. The sample is loaded on a specified geometry instrument and different types of sweep measurements can be performed [132,134].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

et al. 2020

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“…In comparison with previous hybrid hydrogels, the addition of other materials in the hydrogel synthesis resulted in a reduction of degradation, for example, the X : Ge : B : Peg : Ch : G hybrid hydrogel had a minimal degradability of 0.24. Mechanical fragility and quicker breakdown trend are two drawbacks of Ch-Peg-based hydrogels [48]. Avoiding the drawbacks, beneficial properties can be used in the composition.…”

Section: Time-dependent Biodegradabilitymentioning

confidence: 99%

Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model

Hasan

Uddin

Zabin

et al. 2021

International Journal of Biomaterials

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Thermal burns are a major cause of death and suffering around the globe. They can cause debilitating, life-altering injuries as well as lead to significant psychological and financial consequences. Several research works have been conducted in attempt to find a wound healing therapy that is successful. At present, hydrogels have been widely used in cutting-edge research for this purpose because they have suitable properties. This study aimed to see how therapy with chitosan-polyethylene glycol (Ch-Peg) based hydrogels affected the healing of burn wounds in rats. With the concern of public health, xanthan gum (X), boric acid (B), gelatin (Ge), polyethylene glycol (Peg), chitosan (Ch), glutaraldehyde (G), and HPLC-grade water were prepared using X : Ge : G, X : Ge : Peg : G, X : Ge : Ch : G, X : Ge : Peg : Ch : G, X : Ge : B : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch : G. The produced composite hydrogels were examined for swelling ability, biodegradability, rheological characteristics, and porosity. The 3D structure of the hydrogel was revealed by scanning electron microscopy (SEM). After that, the structural characterization technique named Fourier-transform infrared spectroscopy (FTIR) was used to describe the composites (SEM). Lastly, in a rat skin wound model, the efficacy of the produced hydrogels was studied. Swelling ability, biodegradability, rheological properties, and porosity were all demonstrated in composite hydrogels that contained over 90% water. Hydrogels with good polymeric networks and porosity were observed using SEM. The existence of bound water and free, intra- and intermolecule hydrogen-linked OH and NH in the hydrogels was confirmed using FTIR. In a secondary burned rat model, all hydrogels showed significant wound healing effectiveness when compared to controls. When compared to other composite hydrogels, wounds treated with X : Ge : Peg : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch:G recovered faster after 28 days. In conclusion, this research suggests that X : Ge : Peg : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch : G could be used to treat skin injuries in the clinic.

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“…72 The increase in the chitosan–METMS and chitosan–METAC hydrogel’ glass transition temperatures can confirm the improvement in the thermal stability of the hydrogel. 72 In one study, a similar DSC trend was reported for glutaraldehyde cross-linked chitosan, and the endothermic peaks were observed in the range of 130 and 155 °C. 29…”

Section: Results and Discussionmentioning

confidence: 89%

Impact of Counter Ions of Cationic Monomers on the Production and Characteristics of Chitosan-Based Hydrogel

2019

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Chitosan-based hydrogel has received considerable interests because of its appealing properties and applications in many areas. The primary objective of this work was to produce novel cationic chitosan-based hydrogels via polymerizing chitosan with two cationic monomers of the same structure but with different counter ions [2-(methacryloyloxy)ethyl]trimethylammonium methyl sulfate (METMS) and [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METAC). Polymerization of chitosan with the cationic monomers performed under the conditions of 50 °C, 5 h, 7 pH, and 2/1 mol/mol monomer/chitosan led to chitosan–METMS and −METAC with the cationic charge densities of 3.22 and 2.88 mequiv/g, respectively. Elemental analysis, gel permeation chromatography, Fourier transform infrared, X-ray diffraction, and differential scanning calorimetry analyses were used to confirm the impact of counter ions of cationic monomers (i.e., polarizability of monomers) on their polymerization performance and the characteristics of induced chitosan-based hydrogels. Also, the results of this work postulated that the counter ions associated with the monomers could dramatically impact the water uptake and swelling properties of the generated chitosan-based hydrogels as well as their performance in adsorbing an anionic dye from a simulated solution.

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Rheological behavior of biodegradable N-succinyl chitosan-g-poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release

Cited by 49 publications

References 46 publications

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model

Impact of Counter Ions of Cationic Monomers on the Production and Characteristics of Chitosan-Based Hydrogel

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