Rheumatic manifestations associated with human immunodeficiency virus infection

Espinoza, Luis R.; Aguilar, José; Berman, Alberto; Gutiérrez, Francisco Javier Álvarez; Vasey, Frank B.; Germain, Bernard F.

doi:10.1002/anr.1780321221

Cited by 59 publications

(16 citation statements)

References 39 publications

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“…Our case rcport of a patient with HTLV-I infection, S S , and proliferative synovitis may support this hypothesis (15). Recently, clinical symptoms and histopathologic changcs in glandular tissues, commonly observed in SS, were also recognized in paticnts with AIDS (39,40). Even though the pathogcnesis of SS in HIV infection remains unclcar, this is further evidence that exogenous rctrovirus is somehow rclatcd to SS.…”

supporting

confidence: 70%

Human T lymphotropic virus type I in arthropathy and autoimmune disorders

Nishioka

Sumida

Hasunuma

1996

Arthritis & Rheumatism

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supporting

confidence: 70%

Human T lymphotropic virus type I in arthropathy and autoimmune disorders

Nishioka

Sumida

Hasunuma

1996

Arthritis & Rheumatism

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“…12 (December 1992) histocompatibility complex (MHC)-restricted CD4+ T cells are likely to be involved in the recognition of specific antigen in the inflamed synovium (8). Finally, RA patients with reduced numbers or reduced function of circulating CD4+ cells because of infection with the human immunodeficiency virus have been reported to show improvement (9).…”

mentioning

confidence: 99%

Rheumatoid synovium is enriched in CD45RB^dim mature memory T cells that are potent helpers for B cell differentiation

Thomas

McIlraith

Davis

et al. 1992

Arthritis & Rheumatism

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Objective. To delineate the phenotype and function of synovial T cells in rheumatoid arthritis (RA).Methods. T cells from normal subjects or from RA peripheral blood (PB), synovial fluid (SF), or synovial tissue (ST) were analyzed phenotypically and functionally.Results. RA SF and ST T cells were found to be markedly enriched in CD45RAdim, CD45RO+, CD45RB-mature memory cells, whereas in the PB, CD45RAbdght naive T cells were more frequent than CD45RO+ memory T cells, and only a minority were CD45RBm. SF and ST T cells proliferated less well and produced less interleukin-2 in response to mitogenic stimuli than did PB T cells. However, synovial T cells effectively promoted the production of Ig from normal B cells. Moreover, PB and synovial T cells differed in their capacity to down-regulate immunoglobulin production.Anti-CD3-stimulated PB T cells suppressed Ig production unless their proliferation was prevented with mitomycin C. In contrast, synovial T cells were potent helpers of B cell Ig production regardless of antecedent treatment with mitomycin C. To examine the relationship between the CD45RBdh phenotype and B cell help, CD45RBdi" T cells were sorted from PB. As opposed to

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“…Com relação a estas últimas, surgem em 5% a 25% dos enfermos anti-HIV reatores, imediatamente antes ou de forma concomitante ao desenvolvimento da depressão imunológica. Outros estudos, entretanto, sugerem a ocorrência destas condições em estágios tardios da infecção pelo HIV (16,17) . A forma de apresentação mais comum, tanto nos indivíduos com infecção pelo HIV quanto nos não infectados, é uma oligoartrite grave e persistente, que afeta preferencialmente grandes articulações dos membros inferiores, associada à entesopatia (15,18) .…”

Section: Espondiloartropatias Soronegativasunclassified

“…Muitos doentes também têm outros aspectos clínicos associados como uretrites, conjuntivite, úlceras orais, balanite circinada e ceratodermia blenorrágica preenchendo os critérios diagnósticos da sín-drome de Reiter (19,20) . Aproximadamente 30% a 40% dos (16,21,22) . Geralmente a resposta aos AINEs para controle das dores articulares não é satisfatória (17) , devendo ser avaliado o uso de corticosteróides e/ou imunossupressores, pesando-se os possíveis riscos do uso destes medicamentos, principalmente naqueles pacientes onde outras manifestações de imunodepressão ainda não tiverem ocorrido (16) .…”

Section: Espondiloartropatias Soronegativasunclassified

Manifestações reumáticas da síndrome de imunodeficiência adquirida (AIDS)

Siqueira-Batista

Gomes

Nacif

et al. 2004

Rev. Bras. Reumatol.

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339 ARTIGO DE REVISÃO REVIEW ARTICLE RESUMODiferentes síndromes reumáticas e fenômenos auto-imunes já foram associados à infecção pelo vírus da imunodeficiência humana (HIV), quer pela maior freqüência de adoecimento, quer pela maior gravidade. Ademais, em muitos casos, sintomas e sinais da doença reumática estão presentes na abertura do quadro de infecção pelo HIV (como na síndrome de soroconversão) ou da síndrome de imunodeficiência adquirida (AIDS). O reconhecimento deste horizonte é da maior importância para a prática do reumatologista, tornando-se altamente necessário ampliar a familiaridade com estes conceitos. Revisitar as interseções reumatológicas da infecção pelo HIV -enfatizando-se situações como as espondiloartropatias soronegativas, as artralgias, as artrites infecciosas, fibromialgia, miopatias, vasculites, síndrome linfocítica infiltrante difusa, lúpus eritematoso sistêmico e fenômenos auto-imunes -é, pois, o objetivo do presente artigo.Palavras-chave: manifestações musculoesqueléticas, manifestações reumáticas, vírus da imunodeficiência humana.

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Rheumatic manifestations associated with human immunodeficiency virus infection

Cited by 59 publications

References 39 publications

Human T lymphotropic virus type I in arthropathy and autoimmune disorders

Human T lymphotropic virus type I in arthropathy and autoimmune disorders

Rheumatoid synovium is enriched in CD45RB^dim mature memory T cells that are potent helpers for B cell differentiation

Manifestações reumáticas da síndrome de imunodeficiência adquirida (AIDS)

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Rheumatic manifestations associated with human immunodeficiency virus infection

Cited by 59 publications

References 39 publications

Human T lymphotropic virus type I in arthropathy and autoimmune disorders

Human T lymphotropic virus type I in arthropathy and autoimmune disorders

Rheumatoid synovium is enriched in CD45RBdim mature memory T cells that are potent helpers for B cell differentiation

Manifestações reumáticas da síndrome de imunodeficiência adquirida (AIDS)

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Rheumatoid synovium is enriched in CD45RB^dim mature memory T cells that are potent helpers for B cell differentiation