Rhizopus homothallicus, an emerging pathogen causing cavitary lung lesions

Taneja, Juhi; Chatterjee, Kuhu; Sachdeva, Ruchi; Abbas, Shahid; Sen, Mrittika

doi:10.1099/acmi.0.000526.v3

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…The clinical and radiological manifestations of pulmonary mucormycosis can vary, underscoring the importance of early detection and prompt management to mitigate the high fatality rates associated with this disease. Furthermore, there have been documented cases of Rhizopus species-related mucormycosis in patients with chronic granulomatous disease, affecting both the pulmonary and gastrointestinal systems (Taneja et al, 2023). Additionally, Rhizopus species have been associated with spondylodiscitis, a condition characterized by spinal and intervertebral disc infection, often accompanied by skin lesions (Opara, 2022).…”

Section: Safetymentioning

confidence: 99%

Mycoproteins and their health‐promoting properties: Fusarium species and beyond

Lee,

Pan,

Kim

et al. 2024

Comp Rev Food Sci Food Safe

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Filamentous fungal mycoproteins have gained increasing attention as sustainable alternatives to animal and plant‐based proteins. This comprehensive review summarizes the nutritional characteristics, toxicological aspects, and health‐promoting effects of mycoproteins, focusing on those derived from filamentous fungi, notably Fusarium venenatum. Mycoproteins are characterized by their high protein content, and they have a superior essential amino acid profile compared to soybeans indicating excellent protein quality and benefits for human nutrition. Additionally, mycoproteins offer enhanced digestibility, further highlighting their suitability as a protein source. Furthermore, mycoproteins are rich in dietary fibers, which have been associated with health benefits, including protection against metabolic diseases. Moreover, their fatty acids profile, with significant proportions of polyunsaturated fatty acids and absence of cholesterol, distinguishes them from animal‐derived proteins. In conclusion, the future of mycoproteins as a health‐promoting protein alternative and the development of functional foods relies on several key aspects. These include improving the acceptance of mycoproteins, conducting further research into their mechanisms of action, addressing consumer preferences and perceptions, and ensuring safety and regulatory compliance. To fully unlock the potential of mycoproteins and meet the evolving needs of a health‐conscious society, continuous interdisciplinary research, collaboration among stakeholders, and proactive engagement with consumers will be vital.

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Section: Safetymentioning

confidence: 99%

Mycoproteins and their health‐promoting properties: Fusarium species and beyond

Lee,

Pan,

Kim

et al. 2024

Comp Rev Food Sci Food Safe

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Clinical characteristics, outcome, and factors associated with mortality of pulmonary mucormycosis: a retrospective single-center study from Pakistan

Khalid,

Khanum,

Habib

et al. 2024

Therapeutic Advances in Infection

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Introduction and objective: Pulmonary mucormycosis is a rare but rapidly progressive fatal disease. Limited data exist on the outcomes and factors associated with poor prognosis of pulmonary mucormycosis. The objective of this study was to evaluate clinical characteristics, factors associated with mortality, and outcomes of pulmonary mucormycosis at a tertiary care hospital in Pakistan. Methods: This was a retrospective observational study conducted at a tertiary care hospital in Karachi, Pakistan. Medical records of hospitalized patients diagnosed with proven or probable pulmonary mucormycosis between January 2018 and December 2022 were reviewed. Univariate and regression analyses were performed to identify factors associated with mortality. Results: Fifty-three pulmonary mucormycosis patients (69.8% male) were included, with mean age of 51.19 ± 21.65 years. Diabetes mellitus was the most common comorbidity [ n = 26 (49.1%)]. Chronic lung diseases were present in [ n = 5 (9.4%)], and [ n = 16 (30.2%)] had concurrent coronavirus disease 2019 (COVID-19) pneumonia. The predominant isolated Mucorales were Rhizopus [ n = 32 (60.3%)] and Mucor species [ n = 9 (17%)]. Main radiological findings included consolidation [ n = 39 (73.6%)] and nodules [ n = 14 (26.4%)]. Amphotericin B deoxycholate was prescribed in [ n = 38 (71.7%)], and [ n = 14 (26.4%)] of patients received combined medical and surgical treatment. The median [interquartile range (IQR)] hospital stay was 15.0 (10.0–21.5) days. Intensive care unit (ICU) care was required in [ n = 30 (56.6%)] patients, with 26 (49.1%) needing mechanical ventilation. Overall mortality was seen in 29 (54.7%) patients. Significantly higher mortality was found among patients requiring mechanical ventilation 20/29 (69%, p = 0.002). Immunosuppression ( p = 0.042), thrombocytopenia ( p = 0.004), and mechanical ventilation ( p = 0.018) were identified as risk factors for mortality on multivariable analysis. Conclusion: This study provides essential insights into the clinical characteristics, outcomes, and mortality factors associated with pulmonary mucormycosis. The mortality rate was high (54.7%), particularly in patients with immunosuppression, thrombocytopenia, and those who required mechanical ventilation.

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Rhizopus homothallicus, an emerging pathogen causing cavitary lung lesions

Cited by 2 publications

References 19 publications

Mycoproteins and their health‐promoting properties: Fusarium species and beyond

Mycoproteins and their health‐promoting properties: Fusarium species and beyond

Clinical characteristics, outcome, and factors associated with mortality of pulmonary mucormycosis: a retrospective single-center study from Pakistan

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