“…[12][13][14] Conversely, regardless of the assembly method, polymersomes demonstrate increased mechanical stability compared to liposomes, efficient drug entrapment, long shelf life, and controllable stimuli-triggered delivery of cargo. [15][16][17][18][19][20][21] In addition, although temperature can be used as a trigger for drug release from nanovesicles due to the elevated temperature in tumor microenvironments because of the high rate of tumor metabolism, 22 imbuing liposomes with precise temperature sensitivity in biologically relevant ranges can be difficult due to the complex nature of their formulations, 23,24 as well as controlling their size to promote predictable ensemble behavior can be challenging due to liposome propensity for wide size distributions upon self-assembly. 25 Therefore, the development of polymersomes that are mechanically robust, have efficient drug loading capacity, and can intelligently respond to environmental stimuli such as temperature or pH, has become of great importance.…”