Riedel’s thyroiditis associated with high titers of antimicrosomal and antithyroglobulin antibodies and hypothyroidism

Zelmanovitz, Flavio; Zelmanovitz, Themis; Beck, M; Cerski, Carlos Thadeu Schmidt; Schmid, Helena; Czepielewski, Mauro Antônio

doi:10.1007/bf03347770

Cited by 22 publications

(8 citation statements)

References 15 publications

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“…The disease may be associated with subacute and chronic thyroiditis, thus some authors proposed the, so called, "intrathyroidal hypothesis". According to that hypothesis, the entity may represent the late stage (i.e., the progression to fibrotic stage) of chronic inflammatory disorder [6-8]. On the contrary, the "pharmacological hypothesis" suggests that some particular medications may trigger Riedel's thyroiditis development [8].…”

Section: Discussionmentioning

confidence: 99%

Riedel's thyroiditis - a case report with genes' expression studies

Wojciechowska-Durczynska

Durczyński

Sporny

et al. 2012

Thyroid Res

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BackgroundGenetic background of Riedel's thyroiditis remains unknown. Herein, we describe our results of studies on genes expression levels in Riedel's thyroiditis.Case report and genetic findingsWe report the case of 48-year old woman with Riedel's thyroiditis who has presented unusual course of disease with non-specific cervical discomfort, though as with no pain and/or no compression symptoms. After surgery, thyroid specimens were quantitatively evaluated, regarding PIK3CA, PIK3CD, PIK3CG, Tg, TGFB1, THRB, COL1, CDKN1C, CDH3 and CACNA2D2 genes expression levels, by real-time PCR in the ABI PRISM® 7500 Sequence Detection System. Out of 10 above genes, in 2 cases the expression was higher than in respective Controls of unchanged thyroid tissue. In the remaining 8 cases, expression in question became comparable or lower as in Controls.DiscussionThe association between increased expression levels of PIK3CA and CDH3 genes and Riedel's thyroiditis is not well-defined. However, the increased expression of PIK3CA and CDH3 genes in our case report and in previous studies of other authors on various malignancies may suggest possible molecular relation between Riedel's thyroiditis and certain neoplastic processes, the relation of which requires further genetic evaluation. It is to be stressed that gene expression studies in Riedel's thyroiditis are difficult to perform, mainly due to fibrosis, resulting in scarce thyroid specimens and - in consequence - small amount of genetic material.

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Section: Discussionmentioning

confidence: 99%

Riedel's thyroiditis - a case report with genes' expression studies

Wojciechowska-Durczynska

Durczyński

Sporny

et al. 2012

Thyroid Res

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“…The theory of "intrathyroidal hypothesis" claiming that Riedel's thyroiditis represent the late stage chronic inflammatory disorder of the thyroid characterized by progression of the fibrosis. [9,22,23] On the contrary, the "pharmacological hypothesis" suggests that some particular medications may trigger Riedel's thyroiditis development. [9,24] Although not proven, inherited susceptibility and development was hypothesized, as well.…”

Section: Discussionmentioning

confidence: 99%

Riedel's thyroiditis in a black African: A case report and review of literature

Arowolo¹,

Ige²,

Odujoko³

et al. 2016

Niger J Clin Pract

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Riedel's thyroiditis is a rare cause of the enlargement of the thyroid gland. The etiology is not fully known. There has been no report of Riedel thyroiditis in our country. We report a case of a 61-year-old man with the disease as well as review the literature. We present the case of 61-year-old carpenter seen in our clinic with 2½ years history of painless anterior neck swelling associated with hoarseness of voice. He had multiple hard nodules on the left lobe of the thyroid gland with multiple cervical lymph nodes enlargement. No feature of hypothyroidism or thyroiditis. Clinical diagnosis of malignant goiter was made although Fine-needle aspiration for cytology did not suggest malignancy. He had surgery, findings included nonresectable hard multinodular left thyroid lobe from which a wedge biopsy was taken, Histology of the specimen revealed Riedel's thyroiditis. He was managed with oral Prednisolone and Tamoxifen with remarkable improvement in his clinical symptoms. Riedel's thyroiditis is a rare disease. It can easily mimic malignant goiter hence proper histological diagnosis will be necessary to differentiate. Review of medical literature showed that Riedel thyroiditis has not been reported in a black African patient inhabiting the sub-Sahara Africa. This was a report of Riedel thyroiditis in a black Nigerian patient that was successfully managed on oral glucocorticoid, tamoxifen and L-thyroxine.

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“…Histopathologically, Riedel's thyroiditis is considerably different from subacute thyroiditis, but may be similar to fibrous Hashimoto's thyroiditis [12]. Riedel's thyroiditis was once considered an advanced form of Hashimoto's thyroiditis [13], but recently has been classified as an independent disease [14]. Subacute thyroiditis is much more common than Riedel's thyroiditis, and the two diseases are classified separately [15].…”

Section: Discussionmentioning

confidence: 99%

Riedel's Thyroiditis in a Patient with Recurrent Subacute Thyroiditis: A Case Report and Review of the Literature

et al. 2007

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Abstract. Riedel's thyroiditis is a rare form of chronic thyroiditis, characterised by a fibroinflammatory process that partially destroys the thyroid and often involves surrounding tissues. The relationship of Riedel's thyroiditis to other forms of thyroiditis is not clear. A case of Riedel's thyroiditis in a 51-year-old woman presenting with symptoms of subacute thyroiditis, is reported. She was diagnosed with subacute thyroiditis based on clinical manifestation and laboratory results. She was treated with glucocorticoids for six weeks, and then followed-up for 12 months. Three years later, she visited with tenderness and enlargement of thyroid mass, and laboratory and radiology findings suggested that she had a malignant thyroid tumor as well as subacute thyroiditis. After thyroidectomy, histopathologic findings showed that she had Riedel's thyroiditis in the presence of subacute thyroiditis. Until now, few cases of Riedel's thyroiditis in patients with a history of subacute thyroiditis have been reported in the literature. Although the etiology of Riedel's thyroiditis is unknown, it may develop in the course of subacute thyroiditis. Case ReportA 51-year-old woman presented in our clinic with sudden onset of painful swelling in anterior neck. She had been treated for upper respiratory infection at another clinic 2 weeks prior to this visit. Her height was 156 cm, weight 61 kg, blood pressure 140/90 mmHg, pulse rate 106 per minute, respiration rate 18 per minute, and body temperature 37.1°C. Her thyroid was diffusely enlarged, quite firm, and tender. A fairly fixed nodule (2.0 × 1.0 cm) was palpated in the left thyroid gland. Abnormal laboratory findings included elevated erythrocyte sedimentation rate (ESR) of 61 mm/hr, and elevated serum T 3 of 209 ng/dL (normal, 84-157 ng/dL), elevated serum T 4 of 13.0 µg/dL (normal, 4.7-9.3 µg/dL), and a decreased TSH level of 0.1 µIU/mL (normal, 0.39-3.68 µIU/mL). Both anti-thyroperoxidase (anti-TPO) antibody and antithyroglobulin (anti-Tg) antibody were negative and anti-TSH receptor antibody was also negative. Thyroid radioiodine uptake ratio was 3.42% after 2 hours and 3.10% after 24 hours. Fine needle aspiration cytology (FNAC) of the suspect thyroid nodule was negative, however, there was infiltration of lymphocytes and leukocytes, and several giant cells were observed.

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Riedel’s thyroiditis associated with high titers of antimicrosomal and antithyroglobulin antibodies and hypothyroidism

Cited by 22 publications

References 15 publications

Riedel's thyroiditis - a case report with genes' expression studies

Riedel's thyroiditis - a case report with genes' expression studies

Riedel's thyroiditis in a black African: A case report and review of literature

Riedel's Thyroiditis in a Patient with Recurrent Subacute Thyroiditis: A Case Report and Review of the Literature

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