Riedel's thyroiditis association with IgG4-related disease

Stan, Marius N.; Sonawane, Vikram; Sebo, Thomas J.; Thapa, Prabin; Bahn, Rebecca S.

doi:10.1111/cen.13238

Cited by 31 publications

(16 citation statements)

References 23 publications

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“…Fatourechi et al confirmed the presence of IgG4+ plasmacytes in two patients with RT [62]. Stan, et al more recently reported six cases of RT, and three patients showed IgG4+ plasmacytes >10/HPF [64]. Of those 12 patients including our two cases, only one patient met the comprehensive criteria [45].…”

Section: Rt and Igg4supporting

confidence: 60%

Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases

et al. 2019

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Various thyroid diseases are associated with autoimmunity. Major autoimmune thyroid diseases are Graves' disease (GD) and Hashimoto's thyroiditis (HT). Thyrotropin receptor is an autoantigen in GD, and its immunogenicity has been examined. Immune-checkpoint inhibitor (ICI) is recently widely used for treatment of malignant tumors, but cases of thyroid diseases during ICI treatment have been increasing. Thyroid diseases during ICI therapy have been investigated in immunological and clinical aspects, and their Japanese official diagnostic guidelines were established. In addition, serum and tissue immunoglobulin-G4 levels have been examined in association with clinicopathological characteristics in GD, HT, and Riedel's thyroiditis. We review these diseases associated with thyroid autoimmunity and comprehensively discuss their potential application in future research and therapeutic options.

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Section: Rt and Igg4supporting

confidence: 60%

Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases

et al. 2019

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“…The final proof was provided in 2010, by description of a case in which immunohistochemistry for IgG4 showed an intense positive staining (29). The study by Stan et al, although limited to six cases of RT, currently represents the largest published series (32). The relevance of this study stems from the finding that IgG4 staining was most intense in areas of marked inflammation and was virtually absent in fibrotic areas.…”

Section: Riedel's Thyroiditismentioning

confidence: 78%

DIAGNOSIS OF ENDOCRINE DISEASE: IgG4-related thyroid autoimmune disease

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Coperchini

et al. 2019

European Journal of Endocrinology

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IgG4-related disease (IgG4-RD) is fibro-inflammatory, immune-mediated, systemic disease recognized as a defined clinical condition only in 2001. The prevalence of IgG4-RD is 6/100 000, but it is likely to be underestimated due to insufficient awareness of the disease. The diagnostic approach is complex because of the heterogeneity of clinical presentation and because of rather variable diagnostic criteria. Indeed, high concentrations of IgG4 in tissue and serum are not a reliable diagnostic marker. The spectrum of IgG4-RD also includes well-known thyroid diseases including Riedel’s thyroiditis, Hashimoto’s thyroiditis and its fibrotic variant, Graves’ disease and Graves’ orbitopathy. Results from clinical studies indicate that a small subset of patients with the above-mentioned thyroid conditions present some features suggestive for IgG4-RD. However, according to more recent views, the use of the term thyroid disease with an elevation of IgG4 rather than IgG4-related thyroid diseases would appear more appropriate. Nevertheless, the occurrence of high IgG4 levels in patients with thyroid disease is relevant due to peculiarities of their clinical course.

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“…Clinically, the disease commonly manifests as a mass lesion with or without systemic symptoms [21]. Many distinct inflammatory disorders, for example Riedel thyroiditis, have been revealed to be closely connected to IgG4-RD [21,22]. Although its involvement in the parathyroid gland has not been reported and supportive clinical information, for example serum IgG4 level, was not evaluated in this patient before the operation, the characteristic histopathological features observed in this patient indicate that the tumor of this patient has the features of IgG4-RD [20].…”

Section: Discussionmentioning

confidence: 99%

“…IgG4-RD usually decreases the functions of the involved organs by inducing scar-like fibrosis, e.g. Riedel thyroiditis or autoimmune pancreatitis [22]. However, organ-stimulatory effect of IgG4 was described in a portion of Graves' disease [24,25].…”

Section: Discussionmentioning

confidence: 99%

Parathyroid adenoma with prominent lymphocytic infiltrate having histological features highly suggestive of IgG4-related disease: a case report and literature review

et al. 2019

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Parathyroid adenoma with prominent lymphocytic infiltrate is a rare disease. Until now, 11 patients have been reported. Herein, we report a 57-year-old man who had a neck mass that was incidentally found. Aspiration cytology and subsequent needle biopsy of the tumor were performed and suggested papillary thyroid carcinoma. From the resected specimen, however, the patient was finally diagnosed with parathyroid adenoma with prominent lymphocytic infiltrate, characterized by hyperplastic parathyroid cells with nuclear atypia within fibrotic stroma along with numerous lymphocytes forming germinal centers. Some eosinophils and plasma cells were also observed with some histological features highly suggestive of IgG4-related disease (IgG4-RD), including increased IgG4-positive plasma cells and IgG4/IgG-positive plasma cell ratio, storiform-type fibrosis, and obliterative phlebitis. It turned out that microfollicular or trabecular architecture and cellular atypia with high expression of HBME-1 observed in the aspiration cytology and needle biopsy had been misinterpreted as a thyroid malignancy. This is the first report describing microscopic features of aspiration cytology and needle biopsy of parathyroid adenoma with prominent lymphocytic infiltrate, warning that it can mimic papillary thyroid carcinoma in biopsy specimens. Furthermore, the IgG4-RD-like features of the present case and previous reports imply that parathyroid adenoma with prominent lymphocytic infiltrate may be a type of IgG4-RD.

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Riedel's thyroiditis association with IgG4-related disease

Abstract: Riedel's thyroiditis is a component of IgG4-RD with the density of the IgG4 + lymphocytic infiltrate being time dependent. In this small study, we did not identify differences in IgG4 infiltration between RT and HT, minimizing the utility of this marker in RT diagnosis.

Cited by 31 publications

References 23 publications

Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases

Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases

DIAGNOSIS OF ENDOCRINE DISEASE: IgG4-related thyroid autoimmune disease

Parathyroid adenoma with prominent lymphocytic infiltrate having histological features highly suggestive of IgG4-related disease: a case report and literature review

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