Right atrial ball thrombus associated with atrial septal occluder device: A late complication of transcatheter atrial septal defect closure

Kalaycı, Belma; Kalaycı, Süleyman

doi:10.14744/anatoljcardiol.2017.8012

Cited by 3 publications

(3 citation statements)

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“…However, an important consideration for percutaneous ASD closure is the long-term and ultra-long-term complications that have emerged after its widespread adoption. Some of these, including cardiac erosion (15,(20)(21)(22)(23), infective endocarditis (24,25), and thromboembolism (26,27), carry unignored morbidity and mortality (4,28). We report a case of spontaneous perforation of the PVA membrane observed after 18 years in a patient treated with a 40-mm mushroom umbrella occlude (Huayi Shengjie Co., Ltd., Beijing, China).…”

Section: Discussionmentioning

confidence: 99%

A Rare Ultra-Long-Term Complication of Occluder Recanalization Due to Spontaneous Perforation of Polyvinyl Alcohol Membrane of Atrial Septal Defect Occluder: A Case Report and Review of the Literature

Xiang

Zhuang²,

Wu³

et al. 2022

Front. Cardiovasc. Med.

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Percutaneous closure of atrial septal defect (ASD) has emerged as a feasible alternative strategy to surgical repair in many cardiac centers worldwide. Occluder recanalization due to device failure is a rare and severe complication that often occurs within weeks to years after ASD closure. We reported a rare ultra-long-term complication of occluder recanalization due to delayed spontaneous perforation of polyvinyl alcohol (PVA) membrane of ASD occluder after 18 years of ASD closure. Surgical removal of the faulty device and reconstruction of the atrial septum with a bovine pericardial patch was performed. The patient was discharged and recovered uneventfully without syncope or residual shunt. The cause of this rare complication of spontaneous PVA membrane perforation of the occluder has not been fully detected. To our knowledge, this is the first report about PVA membrane perforation of an occluder that occurred soon after ASD closure.

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Section: Discussionmentioning

confidence: 99%

A Rare Ultra-Long-Term Complication of Occluder Recanalization Due to Spontaneous Perforation of Polyvinyl Alcohol Membrane of Atrial Septal Defect Occluder: A Case Report and Review of the Literature

Xiang

Zhuang²,

Wu³

et al. 2022

Front. Cardiovasc. Med.

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“…One of the most important indicators for evaluating the histocompatibility of the occluder is the endothelialization induced by the occluders. Endothelialization is crucial and of major clinical importance and impaired endothelialization may lead to prolonged anticoagulant therapy and even serious complications such as residual shunt, device-related thrombosis, endocarditis, and occluder displacement ( Chessa et al, 2004 ; Nguyen et al, 2016 ; Kalayc and Kalayc, 2017 ; Chen et al, 2018 ; Li et al, 2020 ). Therefore, the observation of endothelialization after occluder implantation is particularly important.…”

Section: Discussionmentioning

confidence: 99%

Key Regulatory Differentially Expressed Genes in the Blood of Atrial Septal Defect Children Treated With Occlusion Devices

Tang

Yue-jin

et al. 2021

Front. Genet.

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Atrial septal defects (ASDs) are the most common types of cardiac septal defects in congenital heart defects. In addition to traditional therapy, interventional closure has become the main treatment method. However, the molecular events and mechanisms underlying the repair progress by occlusion device remain unknown. In this study, we aimed to characterize differentially expressed genes (DEGs) in the blood of patients treated with occlusion devices (metal or poly-L-lactic acid devices) using RNA-sequencing, and further validated them by qRT-PCR analysis to finally determine the expression of key mediating genes after closure of ASD treatment. The result showed that total 1,045 genes and 1,523 genes were expressed differently with significance in metal and poly-L-lactic acid devices treatment, respectively. The 115 overlap genes from the different sub-analyses are illustrated. The similarities and differences in gene expression reflect that the body response process involved after interventional therapy for ASDs has both different parts that do not overlap and the same part that crosses. The same portion of body response regulatory genes are key regulatory genes expressed in the blood of patients with ASDs treated with closure devices. The gene ontology enrichment analysis showed that biological processes affected in metal device therapy are immune response with CXCR4 genes and poly-L-lactic acid device treatment, and the key pathways are nuclear-transcribed mRNA catabolic process and proteins targeting endoplasmic reticulum process with ribosomal proteins (such as RPS26). We confirmed that CXCR4, TOB1, and DDIT4 gene expression are significantly downregulated toward the pre-therapy level after the post-treatment in both therapy groups by qRT-PCR. Our study suggests that the potential role of CXCR4, DDIT4, and TOB1 may be key regulatory genes in the process of endothelialization in the repair progress of ASDs, providing molecular insights into this progress for future studies.

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“…A previous case report showed erosion 4 years after atrial septal occlusion 13) . Another case report described device thrombosis that occurred 7 years after atrial septal occlusion 14) .…”

Section: Discussionmentioning

confidence: 99%

Safety and effectiveness of transcatheter closure of atrial septal defects: Initial results in Fukushima Prefecture

Kobayashi

Kunii

Yokokawa

et al. 2018

FJMS

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Background : Atrial septal defect is the third most common type of congenital heart disease. Surgical closure was the standard treatment for atrial septal defects before transcatheter closure was approved as minimally invasive treatment in Japan in 2006. In our hospital, this procedure has been performed since 2015. Objective : To evaluate the safety and effectiveness of transcatheter closure of atrial septal defects in our hospital. Methods : Thirty patients (mean age 57.0 ± 19.7 years, 11 males), who underwent transcatheter closure of atrial septal defect between September 2015 and February 2018 at the Fukushima Medical University Hospital, were enrolled. All procedures were performed under general anesthesia with angiographic and transesophageal echocardiographic guidance. Safety and effectiveness were evaluated by the procedural results and complications. Results : All 30 patients successfully underwent transcatheter closure of atrial septal defects and no patient developed complications. New York Heart Association functional class was improved, and the right ventricular area and right atrium area were decreased, postoperatively. Conclusion : Transcatheter closure is a safe and effective treatment for atrial septal defects, and thus could be an alternative option to open heart surgery.

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Right atrial ball thrombus associated with atrial septal occluder device: A late complication of transcatheter atrial septal defect closure

Cited by 3 publications

References 0 publications

A Rare Ultra-Long-Term Complication of Occluder Recanalization Due to Spontaneous Perforation of Polyvinyl Alcohol Membrane of Atrial Septal Defect Occluder: A Case Report and Review of the Literature

A Rare Ultra-Long-Term Complication of Occluder Recanalization Due to Spontaneous Perforation of Polyvinyl Alcohol Membrane of Atrial Septal Defect Occluder: A Case Report and Review of the Literature

Key Regulatory Differentially Expressed Genes in the Blood of Atrial Septal Defect Children Treated With Occlusion Devices

Safety and effectiveness of transcatheter closure of atrial septal defects: Initial results in Fukushima Prefecture

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