Right atrial, right ventricular and left ventricular thrombi in (incomplete) Behcet's disease

Vanhaleweyk, G.; El-Ramahi, Kamal M.; Hazmi, Manal Al; Sieck, Jens O.; Zaman, Liaqat; Fawzy, Mohamed

doi:10.1093/oxfordjournals.eurheartj.a059619

Cited by 56 publications

(29 citation statements)

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“…ICT is located usually in the right side of the heart, the right ventricle being the most common location (6). Involvement of the left heart has been rarely reported (7). In our case series, the right heart was involved in all cases with right ventricular thrombosis in 5 cases and right atrial thrombosis in 3 cases.…”

Section: Casementioning

confidence: 56%

Intracardiac thrombus in Behçet’s disease

2016

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Behçet’s disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus (ICT) formation is an uncommon but important complication of BD. Of the cases of Behçet’s disease, we selected those with ICT. All patients fulfilled the diagnostic criteria of the International Study Group of Behçet’s disease. The ICT in each case was confirmed by ultrasonography, computed tomography and MRI. Clinical features and laboratory parameters were determined. Among our 518 patients with BD, 8 were diagnosed as having intracardiac thrombus (ICT). All were male; the mean age at the time of the ICT diagnosis was 30.8 years. The main presenting symptoms were hemoptysis, chest pain, and dyspnea. It was associated with pulmonary artery aneurysm and vena cava thrombosis in 3 cases each, pulmonary embolism, and lower limbs deep venous thrombosis in 1 case each. The coexistence of other cardiac complications was as follows: pericarditis in 2 cases, myocarditis, endomyocardial fibrosis, and coronary arteritis with consequent myocardial infarction in one case each. In all cases, echocardiography was sufficient to reach the diagnosis. Chest computed tomography performed in all cases led to the diagnosis of associated pulmonary vasculo-Behçet lesions in 4 cases. All patients received colchicine, anticoagulation, and corticosteroids. Seven patients were on immunosuppressant agents (2 patients received azathioprine and 5 cyclophosphamide). Clinical remission with ICT resolution was observed in 5 cases. Combined immunosuppressive therapy with prednisone and cyclophosphamide might be needed to treat ICT due to BD.

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Section: Casementioning

confidence: 56%

Intracardiac thrombus in Behçet’s disease

2016

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“…Ozkan et al (6) demonstrated that there is no difference in the prevalence of echocardiographic abnormalities between patients with BD and control subjects. Since the first description by Buge in 1977 (7) up to date, only about 50 cases have been reported (1,2,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Intracardiac Thrombus in a Young Man: Don't Forget Behçet's Disease!

et al. 2012

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Intracardiac thrombosis is an exceptional complication of Behçet's disease. The management of this involvement is difficult due to the risk of recurrence. We present the case of a young man admitted to our hospital for intermittent fever. The microbiologic investigations did not show any causative germ. We discovered a right ventricle thrombus on echocardiography. We confirmed the diagnosis of pulmonary embolism on CT angiogram. The patient developed oral and genital ulcerations which were consistent with Behçet's syndrome. The thrombus had disappeared after treatment with anticoagulant, corticosteroid and immunosuppressors. Intracardiac thrombosis can reveal Behçet's disease. An exhaustive examination and close monitoring should be performed in order to reveal pathognomonic signs as soon as possible and to promptly start the appropriate treatment.

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“…Only 10 cases have been reported to date in the English literature. [3][4][5][6][7][8][9][10][11] As well, pulmonary involvement with this disease is rare, with the usual clinical presentation of pulmonary involvement being recurrent massive hemoptysis. 10,12 Repetitive pulmonary embolism has been reported in only 3 cases.…”

Section: Discussionmentioning

confidence: 99%