Right-sided Infective Endocarditis with Ventricular Free Wall Vegetation Caused by &lt;i&gt;Abiotrophia defectiva&lt;/i&gt; in a Patient with Unrepaired Ventricular Septal Defect

Miyawaki, Norihisa; Okada, Taiji; Koyama, Tadaaki; Furukawa, Yutaka

doi:10.2169/internalmedicine.9374-22

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Although their role as causative agents of IE is known [7][8][9][10][11], their incidence, diagnostic and clinical management is not completely defined. Most data published in the literature report single clinical cases, with heterogeneous char-acteristics [12][13][14][15], and data on the real impact of this entity are very scarce. Case series described focus on clinical aspects, providing scarce information on the role of microbiological diagnosis [16,17].…”

Section: Introductionmentioning

confidence: 99%

Abiotrophia spp. and Granulicatella spp. Infective Endocarditis: A Contemporary Perspective

Estévez¹,

Marı́n²,

Sánchez‐Carrillo³

et al. 2022

Front. Biosci. (Elite Ed)

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Background: Abiotrophia spp. and Granulicatella spp. are Gram-positive cocci, formerly known as nutritionally variant or deficient Streptococcus. Their role as causative agents of infective endocarditis (IE) is numerically uncertain, as well as diagnostic and clinical management of this infection. The aim of our study is to describe the clinical, microbiological, therapeutic, and prognosis of patients with IE caused by these microorganisms in a large microbiology department. Methods: Retrospective analysis of all the patients with Abiotrophia spp. and Granulicatella spp. IE registered in our centre in the period 2004-2021. Results: Of the 822 IE in the study period, 10 (1.2%) were caused by Abiotrophia spp. (7) or Granulicatella spp. (3). The species involved were A.defectiva (7), G.adiacens (2) and G.elegans (1). Eight patients were male, their mean age was 46 years and four were younger than 21 years. The most frequent comorbidities were congenital heart disease (4; 40%) and the presence of intracardiac prosthetic material (5; 50%). IE occurred on 5 native valves and 5 prosthetic valve or material. Blood cultures were positive in 8/10 patients, within a mean incubation period of 18.07 hours. In the other two patients, a positive 16SPCR from valve or prosthetic material provided the diagnosis. Surgery for IE was performed in seven patients (70%) and in all cases positive 16S rRNA PCR and sequencing from valve or prosthetic material was demonstrated. Valves and/or prosthetic removed material cultures were positive in four patients. Nine patients received ceftriaxone (4 in monotherapy and 5 in combination with other antibiotics). The mean length of treatment was 6 weeks and IE-associated mortality was 20% at one year follow-up. Conclusions: Abiotrophia spp. or Granulicatella spp. IE were infrequent but not exceptional in our environment and particularly affected patients with congenital heart disease or prosthetic material. Blood cultures and molecular methods allowed the diagnosis. Most of them required surgery and the associated mortality, in spite of a mean age of 46 years, was high.

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Section: Introductionmentioning

confidence: 99%

Abiotrophia spp. and Granulicatella spp. Infective Endocarditis: A Contemporary Perspective

Estévez¹,

Marı́n²,

Sánchez‐Carrillo³

et al. 2022

Front. Biosci. (Elite Ed)

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“… 3 , 4 However, it causes severe disease and is difficult to isolate given its growth media requirements, leading to delay in treatment and misdiagnosis as culture-negative IE. 2 , 3 , 5 …”

Section: Introductionmentioning

confidence: 99%

A Common Defect With a Not So Common Complication: Abiotrophia Defectiva Endocarditis in a Child With Unrepaired Ventricular Septal Defect

Torres-Burgos¹,

Mendez-Castro²,

Alkon³

2022

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Right-sided Infective Endocarditis with Ventricular Free Wall Vegetation Caused by <i>Abiotrophia defectiva</i> in a Patient with Unrepaired Ventricular Septal Defect

Cited by 2 publications

References 16 publications

Abiotrophia spp. and Granulicatella spp. Infective Endocarditis: A Contemporary Perspective

Abiotrophia spp. and Granulicatella spp. Infective Endocarditis: A Contemporary Perspective

A Common Defect With a Not So Common Complication: Abiotrophia Defectiva Endocarditis in a Child With Unrepaired Ventricular Septal Defect

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