Right Ventricular Abnormalities on Cardiovascular Magnetic Resonance Imaging in Patients With Sarcoidosis

Velangi, Pratik S.; Chen, Ko Hsuan Amy; Kazmirczak, Felipe; Okasha, Osama; Wald, Lisa Von; Roukoz, Henri; Farzaneh‐Far, Afshin; Markowitz, Jeremy; Nijjar, Prabhjot S.; Bhargava, Maneesh; Perlman, D.; Akçakaya, Mehmet; Shenoy, Chetan

doi:10.1016/j.jcmg.2019.12.011

Cited by 69 publications

(42 citation statements)

References 49 publications

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“…However, data regarding the predictive capacity of RVEF for mortality in patients with ARDs are rather scarce. According to a CMR study in patients with sarcoidosis, RV systolic dysfunction but not RV LGE was independently associated with all-cause mortality [38]. Nevertheless, it should be kept in mind that there were no differences in biventricular function in our study population after univariable testing, and RVEF could only significantly discriminate between the two groups when correcting for sex.…”

Section: Discussionmentioning

confidence: 68%

Ventricular Tachycardia Has Mainly Non-Ischaemic Substrates in Patients with Autoimmune Rheumatic Diseases and a Preserved Ejection Fraction

et al. 2021

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Non-sustained ventricular tachycardia (NSVT) is a potentially lethal arrhythmia that is most commonly attributed to coronary artery disease. We hypothesised that among patients with NSVT and preserved ejection fraction, cardiovascular magnetic resonance (CMR) would identify a different proportion of ischaemic/non-ischaemic arrhythmogenic substrates in those with and without autoimmune rheumatic diseases (ARDs). In total, 80 consecutive patients (40 with ARDs, 40 with non-ARD-related cardiac pathology) with NSVT in the past 15 days and preserved left ventricular ejection fraction were examined using a 1.5-T system. Evaluated parameters included biventricular volumes/ejection fractions, T2 signal ratio, early/late gadolinium enhancement (EGE/LGE), T1 and T2 mapping and extracellular volume fraction (ECV). Mean age did not differ across groups, but patients with ARDs were more often women (32 (80%) vs. 15 (38%), p < 0.001). Biventricular systolic function, T2 signal ratio and EGE and LGE extent did not differ significantly between groups. Patients with ARDs had significantly higher median native T1 mapping (1078.5 (1049.0–1149.0) vs. 1041.5 (1014.0–1079.5), p = 0.003), higher ECV (31.0 (29.0–32.0) vs. 28.0 (26.5–30.0), p = 0.003) and higher T2 mapping (57.5 (54.0–61.0) vs. 52.0 (48.0–55.5), p = 0.001). In patients with ARDs, the distribution of cardiac fibrosis followed a predominantly non-ischaemic pattern, with ischaemic patterns being more common in those without ARDs (p < 0.001). After accounting for age and cardiovascular comorbidities, most findings remained unaffected, while only tissue characterisation indices remained significant after additionally correcting for sex. Patients with ARDs had a predominantly non-ischaemic myocardial scar pattern and showed evidence of diffuse inflammatory/ischaemic changes (elevated native T1-/T2-mapping and ECV values) independent of confounding factors.

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Section: Discussionmentioning

confidence: 68%

Ventricular Tachycardia Has Mainly Non-Ischaemic Substrates in Patients with Autoimmune Rheumatic Diseases and a Preserved Ejection Fraction

et al. 2021

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“…10 Right ventricular abnormalities (RV systolic dysfunction and late gadolinium enhancement) on cardiovascular magnetic resonance imaging in patients with sarcoidosis have been shown to have adverse outcomes in patients with sarcoidosis. 11 Despite these results, the study had several limitations. First, this is a single-center observational study with a small sample size.…”

Section: Fdg-petmentioning

confidence: 94%

Cardiac sarcoidosis: Advantages and limitations of advanced cardiac imaging

Bokhari

Sheikh

2022

Journal of Nuclear Cardiology

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“…In addition, the ECG pattern described in this study may indicate RV involvement with a higher propensity for ventricular arrhythmias, warranting careful diagnostic testing and follow-up. 23 Last, in most of the patients, extracardiac sarcoidosis Q17 is asymptomatic and only diagnosed after suspicion of CS.3 Therefore, (extra)cardiac sarcoidosis needs to be suspected before adequate tests will be initiated. The ECG algorithm may be of help in initializing additional diagnostic tests.…”

Section: Clinical Implications and Future Perspectivesmentioning

confidence: 99%

The precordial R′ wave: A novel discriminator between cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy in patients presenting with ventricular tachycardia

et al. 2021

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Right Ventricular Abnormalities on Cardiovascular Magnetic Resonance Imaging in Patients With Sarcoidosis

Cited by 69 publications

References 49 publications

Ventricular Tachycardia Has Mainly Non-Ischaemic Substrates in Patients with Autoimmune Rheumatic Diseases and a Preserved Ejection Fraction

Ventricular Tachycardia Has Mainly Non-Ischaemic Substrates in Patients with Autoimmune Rheumatic Diseases and a Preserved Ejection Fraction

Cardiac sarcoidosis: Advantages and limitations of advanced cardiac imaging

The precordial R′ wave: A novel discriminator between cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy in patients presenting with ventricular tachycardia

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