Rising Methicillin-Resistant<i>Staphylococcus aureus</i>Infections in Ear, Nose, and Throat Diseases

Sachithanandam, Sangeetha Thirumazhisi

doi:10.1155/2014/253945

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…It is well known that nasal colonization with S. aureus along with MRSA, particularly in biofilm form, is associated with CRS disease recalcitrance and poor outcomes after sinus surgery [ 27 , 28 , 29 , 30 ]. Biofilms are thought to be the main mediators for disease persistence and treatment failure in various chronic disorders including CRS [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Menberu

Cooksley

et al. 2021

Pathogens

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Corynebacterium accolens is the predominant species of the healthy human nasal microbiota, and its relative abundance is decreased in the context of chronic rhinosinusitis (CRS). This study aimed to evaluate the antimicrobial potential of C. accolens isolated from a healthy human nasal cavity against planktonic and biofilm growth of Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA) clinical isolates (CIs) from CRS patients. Nasal swabs from twenty non-CRS control subjects were screened for the presence of C. accolens using microbiological and molecular techniques. C. accolens CIs and their culture supernatants were tested for their antimicrobial activity against eight S. aureus and eight MRSA 4CIs and S. aureus ATCC25923. The anti-biofilm potential of C. accolens cell-free culture supernatants (CFCSs) on S. aureus biofilms was also assessed. Of the 20 nasal swabs, 10 C. accolens CIs were identified and confirmed with rpoB gene sequencing. All isolates showed variable antimicrobial activity against eight out of 8 S. aureus and seven out of eight MRSA CIs. Culture supernatants from all C. accolens CIs exhibited a significant dose-dependent antibacterial activity (p < 0.05) against five out of five representative S. aureus and MRSA CIs. This inhibition was abolished after proteinase K treatment. C. accolens supernatants induced a significant reduction in metabolic activity and biofilm biomass of S. aureus and MRSA CIs compared to untreated growth control (p < 0.05). C. accolens exhibited antimicrobial activity against S. aureus and MRSA CIs in both planktonic and biofilm forms and holds promise for the development of innovative probiotic therapies to promote sinus health.

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Section: Discussionmentioning

confidence: 99%

Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Menberu

Cooksley

et al. 2021

Pathogens

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“…Rapid onset, severe swelling, tenderness and erythema have been observed before in MRSA head and neck infections, and, when encountered, should raise the index of suspicion of MRSA otitis for the clinician. 22 Patients with MRSA tended to experience a longer time to resolution of symptoms. MRSA AOE tended to be associated with diabetes, immunocompromise and comorbidities to a greater degree than MSSA.…”

Section: Discussionmentioning

confidence: 98%

“…While little is known about MRSA in AOE, increasing rates of MRSA in soft tissue infections 21 and in otolaryngology, 16 , 22 are well-documented. The increased incidence observed in our study, when compared to the earlier findings of Roland et al 3 appear to be consistent with the global trend of increasing prevalence of community-acquired MRSA carriage 18 and infection 17 , 22 over the past 20 years.…”

Section: Discussionmentioning

confidence: 99%

“…While MRSA remained mainly nosocomial in nature through the 1980's, community-acquired MRSA (CA-MRSA) emerged in the 1990's and has become increasingly common in soft tissue and otolaryngologic infections since. 16 , 21 , 22 In 2002, Hwang et al 16 reported >8.5% increase in CA-MRSA incidence in otologic infections in Taiwan. Similarly, in 2007 a group from Hawaii 21 noted a rapid increase in CA-MRSA head and neck infections from 21% to 64% over a five-year period.…”

Section: Introductionmentioning

confidence: 99%

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Methicillin‐resistant Staphylococcus aureus in acute otitis externa

Duarte

Kozin

Bispo

et al. 2018

World j. otorhinolaryngol.-head neck surg.

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ObjectiveOtologic methicillin-resistant Staphylococcus aureus (MRSA) infection has historically been rare, but given the rise in community-acquired MRSA carriage and infection at other body sites, prevalence rates may be changing. The goal of this study was to determine the prevalence of MRSA in recent otologic cultures from patients with acute otitis externa (AOE).Study designRetrospective review of an institutional microbiologic database.MethodsA retrospective analysis was performed on serial culture isolates taken from the ear at a quaternary care hospital from January 2014 to April 2016. The causative pathogen and antibiotic sensitivity was determined by culture isolation and end point mean inhibitory concentration (MIC) testing. Medical records were reviewed to document patient characteristics, chronicity of infection, symptomatology, and previous treatments.ResultsOver the study period, 173 patients were diagnosed with AOE and underwent otologic cultures of the ear. Fifty-three (30.6%) of cultures grew S.aureus (SA). Of SA infections, 15 (28.3%) were identified as MRSA. MRSA patients were typically older than patients with methicillin-sensitive SA (MSSA) (mean age 46.7 ± 17.9 vs 29 ± 19.4, P = 0.003) and had more medical comorbidities (4 vs 1.7, P = 0.001). Compared to patients with MSSA, patients with MRSA were significantly more likely to have had prior ototopical antibiotic exposure (37% vs 73%, P = 0.019).ConclusionContemporary ear culture isolates at quaternary care center show higher rates of MRSA compared to historical reports in the literature. Clinicians should consider ear cultures to identify MRSA AOE.Level of EvidenceIV.

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Postoperation of preauricular fistula cellulitis caused by methicillin-resistant staphylococcus aureus infection

Tian

Zhong

2018

Journal of Otology

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Rising Methicillin-ResistantStaphylococcus aureusInfections in Ear, Nose, and Throat Diseases

Cited by 6 publications

References 18 publications

Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Methicillin‐resistant Staphylococcus aureus in acute otitis externa

Postoperation of preauricular fistula cellulitis caused by methicillin-resistant staphylococcus aureus infection

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