Risk assessment for postoperative venous thromboembolism using the modified Caprini risk assessment model in lung cancer

Abstract

Background Postoperative venous thromboembolism (VTE) is a well-documented cause of morbidity and mortality in lung cancer patients. However, risk identification remains limited. In this study, we sought to analyze the risk factors for VTE and verify the predictive value of the modified Caprini risk assessment model (RAM). Methods This prospective single-center study included patients with resectable lung cancer who underwent resection between October 2019 and March 2021. The incidence of VTE was estimated. Logistic regression was used to analyze the risk factors for VTE. Receiver operating characteristic (ROC) curve analysis was performed to test the ability of the modified Caprini RAM to predict VTE. Results The VTE incidence was 10.5%. Several variables, including age, D-dimer, hemoglobin (Hb), bleeding, and patient confinement to bed were significantly associated with VTE after surgery. The difference between the VTE and non-VTE groups in the high-risk levels was statistically significant (P<0.001), while the low and moderate risk levels showed no significant difference. The combined use of the modified Caprini score and the Hb and D-dimer levels showed an area under the curve (AUC) was 0.822 [95% confidence interval (CI): 0.760–0.855. P<0.001]. Conclusions The risk-stratification approach of the modified Caprini RAM is not particularly valid after lung resection in our population. The use of the modified Caprini RAM combined with Hb and D-dimer levels shows a good diagnostic performance for VTE prediction in patients with lung cancer undergoing resection.

Prognostic value of anticoagulants in resectable gastric cancer

“…Cancer-associated thrombosis, including arterial thrombosis and VTE, signi cantly affects the quality of life and shortens survival. Although risk assessment tools have been shown to be effective in identifying patients at risk for VTE (including Padua prediction score, Caprini risk assessment model, IMPROVE models, the Geneva risk score and the Kucher score) [20][21][22], and there have been advances in perioperative management and prophylaxis measures, the risk of VTE has increased in recent years. The risk of VTE is related to the type of cancer GC is one of the cancers with the highest risk of VTE as well as individual patient differences and new anticancer therapies including antiangiogenic drugs, multi-targeted tyrosine kinase inhibitors, immunomodulatory drug combinations[8, 23,24].…”

The effect of low molecular weight heparin on prognosis of patients with radical gastrectomy

“…Cancer-associated thrombosis, including arterial thrombosis and VTE, signi cantly affects the quality of life and shortens survival. Although risk assessment tools have been shown to be effective in identifying patients at risk for VTE (including Padua prediction score, Caprini risk assessment model, IMPROVE models, the Geneva risk score and the Kucher score) [20][21][22] , and there have been advances in perioperative management and prophylaxis measures, the risk of VTE has increased in recent years. The risk of VTE is related to the type of cancer GC is one of the cancers with the highest risk of VTE as well as individual patient differences and new anticancer therapies including antiangiogenic drugs, multi-targeted tyrosine kinase inhibitors, immunomodulatory drug combinations [8,23,24] .…”