Risk assessment of trace elements in airborne particulate matter deposited on air filters using solid sampling ETV-ICPOES to measure total concentrations and leaching with simulated saliva, gastric juice and lung fluid to estimate bio-accessibility

Scheffler, Guilherme Luiz; Sadiq, Nausheen Waheed; Pozebon, Dirce; Beauchemin, Diane

doi:10.1039/c8ja00128f

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…Three different simulated lung fluids were tested with AZTD in order to optimize results: the Beauchemin lab fluid, Gamble fluid, and an in-house modified Hatch fluid. Subsequent bioaccessibility experiments were conducted on USFA and INFA, in which samples were subjected to timed trials, and supernatants were collected after centrifugation.…”

Section: Methodsmentioning

confidence: 99%

“…The final speciation of these TE in the surrounding depends on the pH, type, and concentration of WSOC. 50 The term "bioavailability" is "the sum of bioaccessibility and bioactivity, which refers to the transport and biochemical processes within tissues". 48 This term is also applicable for similar processes in microorganisms.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Quantifying fully bioaccessible metals from airborne PM is the first step for modeling the pool of dissolved metals for health risk assessment and biogeochemical processes in the SML, respectively. For example, on the former, Schaffler et al measured the total concentrations and leaching of several potentially toxic elements that include Cu, As, and Pb from PM collected on filters with simulated saliva, gastric juice, and lung fluid. They found that 2.5% of Cu and As are released in saliva (10 min, pH 6.5) compared to 26% in gastric juice (2 h, pH <1).…”

Section: Introductionmentioning

confidence: 99%

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Dissolution of Selected Trace Elements from Simulated Atmospheric Aerosol Aging and Human Exposure of Mineral Dust and Coal Fly Ash

Sadiq,

Venter,

Mohammed

et al. 2023

ACS EST Air

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Atmospheric particles from natural and anthropogenic sources contain reactive trace elements (TE) of importance to aerosol multiphase chemistry, health risk assessment of inhalation and ingestion, and ocean productivity. While the dissolution of TE from model and field-collected particles in various aqueous phase conditions of relevance to aerosol liquid water and bodily fluids have received attention, there remain knowledge gaps on (a) benchmark materials and methods for standardizing dissolution experiments and (b) the relevance of dissolution time scales in previously published reports to real-time, long range transport and human exposure. Here, we use fully characterized reference solid materials, namely, Arizona test dust (AZTD) and combustion coal fly ash samples from India, the U.S., and Europe, representative of atmospheric aerosol particles from natural and combustion sources. Using ICP-MS and optimized analytical procedures that address technical challenges with selectivity and sensitivity, we quantified the concentrations of dissolved TE Fe, Cu, Mn, As, and Pb under simulated atmospheric aging (14 days) and human exposure experiments using saliva (5 min), lung fluid (10 min), and gastric juice (1 h). We found that levels of dissolved TE normalized to the total dissolvable levels under strong acid extraction are much higher in simulated aged aerosol water than in bodily fluids of unreacted particles. The significance of these results is discussed in the context of aerosol multiphase chemistry, health impacts, and ocean biogeochemistry.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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