Risk association between scleroderma disease characteristics, periodontitis, and tooth loss

Abstract

Systemic sclerosis (SSc) is a multi-system disorder that can have significant adverse effects on the health of the mouth. The aim of this study was to investigate the associations between the disease characteristics of SSc, periodontal disease (PD), and tooth loss. Fifty-four patients affected by SSc and 55 non-diseased controls were matched for age and gender. SSc was characterized in subtypes and with the mean duration of disease and the Modified Rodnan Skin Score [mRSS]. Patients were surveyed and examined through the evaluation of the periodontal parameters and the number of teeth. A logistic regression analysis showed that patients with SSc presented a higher number of missing teeth (p = 0.001) and a significant median increased odds 2.95 (95% CI 1.26 to 6.84) of PD (defined as clinical attachment loss, CAL) compared to nondiseased controls (6.83, 95% CI 1.94 to 24.36). Moreover, the fewer values of PD was correlated with mRSS in the total SSc group and with the mean duration of disease in patients with limited SSc (p = 0.007), even after adjusting this correlation with the presence of the major organ involvement. This study showed that patients with SSc presented increased odds of PD and tooth loss compared to non-diseased controls. In SSc patients, the magnitude of PD was strongly associated with the mRSS and with the mean duration of the disease. The clinicians should be aware of the potential systemic health problems related to PD.

Association of Periodontitis with Rheumatoid Arthritis and the Effect of Non-Surgical Periodontal Treatment on Disease Activity in Patients with Rheumatoid Arthritis

“…In addition, infectious and opportunistic microbes residing in periodontal pockets may promote the progression of systemic diseases by the spread of bacterial antigens, Gram-negative bacteria, cytokines, and other pro-inflammatory mediators [ 5 ]. PD has been shown to be strongly associated with many autoimmune disorders such as rheumatoid arthritis (RA), systemic sclerosis, and systemic lupus erythematosus [ 6 , 7 ]. Non-surgical therapies including scaling and root planing (SRP) with or without adjuncts are simple and effective procedures for treating PD [ 8 ].…”

Reduced salivary flow and caries status are correlated with disease activity and severity in patients with diffuse cutaneous systemic sclerosis

“… 8 Moreover, a recent study showed that periodontal disease magnitude was strongly associated with mRSS and disease duration in a cohort mainly comprising patients with dcSSc. 28 Therefore, we propose that limited cutaneous SSc and dcSSc should be regarded as separate subtypes of autoimmunity.…”

A Full Diagnostic Process for the Orthodontic Treatment Strategy: A Documented Case Report

“…However, stability cannot be considered as a primary outcome of orthodontic treatment, since a lot of evidence shows that retention protocols are the only way to avoid relapse [ 50 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. Consequently, the choice to extract or not can be driven by other factors, such as facial type and the mandibular symphysis thickness [ 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ]. These parameters nowadays have not been taken too much into account from the literature, however, in our opinion, those factors have great relevance in this complex and insidious decisional process.…”