Risk Factor Analysis of Late Survival After Heart Transplantation According to Donor Profile: A Multi-Institutional Retrospective Study of 512 Transplants

Early Outcomes With Marginal Donor Hearts Compared With Left Ventricular Assist Device Support in Patients With Advanced Heart Failure

“…In a retrospective, single-center analysis, Topkara and colleagues [19] demonstrated that donor age is an independent predictor of recipient survival. Fiorelli and colleagues [20] made similar conclusions in their multi-institutional study of over 500 patients. In an analysis of the UNOS database, Khush and colleagues [21] found a strong relationship between both sex and size mismatch and post-transplantation survival.…”

Chronic alcoholic donors in heart transplantation: A mortality meta-analysis

“…Baseline and surgical characteristics in the donor population and in the recipient population were stated by four studies [3,5,6,10] and were similar in the ADG and NADG groups ( Table 2). Mortality rates were stated by four studies [3,6,9,10]. Pooled mortality was 23.2% (range 7.1% to 48.4%) in the ADG and 20.3% (range 8.5% to 43.8%) in the NADG, in a follow-up period of 2-4 years after transplantation.…”

“…The need for less strict criteria of the donor pool has been opted by several experts [1,2], necessitating re-evaluation of criteria for a marginal donor organ which are currently being repealed. Based on outdated literature [3,4], the International Guidelines advise against transplantation of hearts from alcoholic donors, present in 10-20% of cases [4][5][6], as alcohol could be toxic to myocytes. This review aimed to analyze the mortality rates at follow-up in patients receiving hearts from alcoholic donors.…”

“…Pooled relative risk for mortality was found to be insignificant (RR: 1.19 (95% CI: 0.57 to 2.48)) ( Fig. 2A) [3,6,9,10]. Rejection/graft dysfunction rates at 1 to 43 months of followup were stated by four studies [3][4][5]10].…”

Heart transplantation from older donors

“…установили, что возраст донора старше 40 лет является одним из ведущих факторов, негативно влияющих на ран нюю и отдаленную выживаемость реципиентов сердца. Помимо возраста на результативность ТС оказали отрицательное влияние прижизненные ар териальная гипертензия и СД, сердечнолегочная реанимация, повышенный уровень креатинина и КФКМВ, высокая потребность в норадреналине у сердечного донора [63]. Актуриальная 7летняя выживаемость реципиентов после ТС от доноров >40 лет была ниже (p = 0,0032), чем от доноров <40 лет -соответственно 46,7% против 53,3%.…”