Risk factor profile in young adults with early coronary artery disease and abdominal obesity

Ragino, Yu. I.; Kuzminykh, N. A.; Oblaukhova, V. I.; Шрамко, В.; Денисова, Д. В.; Щербакова, Л. В.

doi:10.17802/2306-1278-2020-9-2-64-73

Kompleks. probl. serdečno-sosud. zabol.

2020

DOI: 10.17802/2306-1278-2020-9-2-64-73

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Risk factor profile in young adults with early coronary artery disease and abdominal obesity

Yu. I. Ragino

N. A. Kuzminykh

V. I. Oblaukhova

et al.

Abstract: Основные положения• Определены статистически значимые факторы риска сердечно-сосудистых заболеваний у молодых лиц, проживающих в Новосибирске, с ранней ишемической болезнью сердца, развившейся на фоне абдоминального ожирения.

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Cited by 2 publications

References 23 publications

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Associations of circulating adipokines and coronary artery disease in young adults

Khudiakova,

Polonskaya,

Shcherbakova

et al. 2024

Cardiovasc Ther Prev

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Aim. To evaluate the associations of abdominal obesity (AO), adipokines and premature coronary artery disease (CAD) in young people for a deeper understanding of the pathogenesis of atherosclerotic diseases.Material and methods. A total of 1457 people were examined, including 653 (44,8%) men. Mean age was 36,7±6,0 years. Premature CAD was detected in 46 people, while 4 following subgroups were formed (138 people in total): with CAD and AO; with CAD, without AO; control groups by age and sex: without CAD, with AO; without CAD, without AO.Results. Premature CAD in young people is associated with an increase in non-high-density lipoprotein cholesterol (non-HDL-C). Univariate analysis found that the probability of CAD increased by 1% with an increase in adiponectin level, and by 0,2% with an increase of 1 ng/ml in resistin level. Multivariate regression analysis, including sex, age, waist circumference, non-HD-C, adiponectin, and resistin, significant associations were obtained for non-HDL-C and adiponectin. With AO, the CAD probability increased by 0,6% with an increase in plasminogen activator inhibitor-1 level (PAI-1). However, when non-HDL-C was included in the model, significance for this biomarker was not achieved.Conclusion. In young people, CAD is associated with increased levels of non-HDL cholesterol, adiponectin, resistin and PAI-1. Independent associations with premature CAD were obtained only for adiponectin, which makes this marker promising for study in young people.

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Associations of circulating adipokines and coronary artery disease in young adults

Khudiakova,

Polonskaya,

Shcherbakova

et al. 2024

Cardiovasc Ther Prev

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Issues of catering for students of medical universities in Russia. Results of the first multicenter study

Кочергина¹,

Батлук²,

Benimetskaya³

et al. 2022

Profil. med.

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Risk factor profile in young adults with early coronary artery disease and abdominal obesity

Cited by 2 publications

References 23 publications

Associations of circulating adipokines and coronary artery disease in young adults

Associations of circulating adipokines and coronary artery disease in young adults

Issues of catering for students of medical universities in Russia. Results of the first multicenter study

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