Risk Factors and Prevalence ofHelicobacter pyloriInfection in Persistent High Incidence Area of Gastric Carcinoma in Yangzhong City

Abstract

Aim. The aim of this study was to investigate the prevalence and risk factors of H. pylori infection in areas with high prevalence of gastric cancer in Jiangsu Province, China. Methods. A prospective epidemiologic survey of H. pylori infection was accomplished in a natural population of 5417 individuals in Yangzhong city. Questionnaires and 13C-urea breath test for H. pylori infection were performed. Results. Among 5417 subjects who completed questionnaires and 13C-urea breath test, 3435 (63.41%) were H. pylori positive. The prevalence reached a peak at the age of 30–39 years (90.82%). There was significant difference between sexes and women had a higher infection rate than men. The prevalence of H. pylori infection was also associated with eating kipper food and fried food. No association between H. pylori prevalence and smoking or drinking was found. Compared to healthy individuals, people with dyspeptic diseases (peptic ulcer, gastroenteritis) presented a high prevalence of H. pylori infection. Using multivariate logistic regression analysis, age and history of peptic ulcer and gastroenteritis were the independent predictors for H. pylori infection. Conclusions. Yangzhong city had a high prevalence of H. pylori infection and was related to several risk factors. The underlying mechanisms are needed to be further investigated.

Decreasing prevalence of Helicobacter pylori according to birth cohorts in urban China

“…Females have higher plasma IgM levels than males; estrogen stimulates immune responses, whereas testosterone is immunosuppressive (32). Smoking is an independent risk factor for H. pylori infection (33,34). In China, the smoking rate is obviously higher in males than in females (35), which may be a factor accounting for the male predominance of H. pylori infection.…”

Perfil sociodemográfico e prevalència do helicobacter pylori em adultos portugueses.

“…Scientific evidence has shown that more than half of the adult population is infected worldwide, with higher frequencies in countries with lower gross domestic product and in lower socioeconomic groups (Lunet, 2011). The calculated value concerning the prevalence of Hp infection -48.8% -was considerably lower than that estimated for the general Portuguese population and closer to (mean 50.15 years) from 6 rural villages in the municipalities of Yangzhong, revealed a higher prevalence of H. pylori in women (64.47% vs. 61.74% p=0.026), whereas the 30-39 year-old group presented a higher percentage of H. pylori (90.82%) with a significant reduction in prevalence with the increase of age (Zhu et al, 2014). The same study did not find any significant differences with other sociodemographic variables (gender, academic qualifications, marital status, income, number of household members and BMI).…”

“…Other evidence shows a decline in prevalence in these age groups, namely the study conducted in the Algarve, which showed an evident progressive reduction of prevalence over 60 years and a higher prevalence between the age of 30 and 59 years (Santos et al, 2010). In China, the study carried out in the municipality of Yangzhong revealed higher prevalences in the age group of 30-39 years (Zhu et al, 2014). Other studies demonstrate clear evidence of the increased prevalence with age (Bastos et al, 2013;Moosazadeh, Lankarani, & Afshari, 2016;Sethi et al, 2013).…”

Increasing antimicrobial resistance of Helicobacter pylori infection among Saudi patients undergoing upper gastrointestinal endoscopy

“…Similarly, Zhu et al found the same prevalence. 11 However, several studies have showed that the prevalence of H. pylori infections decreased with increased age. 12 Several studies in the Middle East Countries have reported different prevalence rates of H. pylori infections.…”