Risk factors and prognostic variables in the ovarian hyperstimulation syndrome

Variations in serum vascular endothelial growth factor binding profiles and the development of ovarian hyperstimulation syndrome

“…Several substances have been proposed as the intermediary responsible for the increase in capillary permeability. However, exaggerated folliculogenesis (4) and the interaction between the immune and reproductive systems (5) are the pathogenetic forerunners. Physiological angiogenesis is infrequent; when it does occur, it seems to be restricted to females (6).…”

Pre-hCG variables associated with occurrence of ascites in IVF/ICSI patients at moderate risk of developing OHSS: A pilot investigation

“…Many investigators have shown that an elevated concentration of estradiol during ovarian stimulation constitutes a risk factor for OHSS [3,5,22,23,35,37,38]. However, as mentioned above, patients presented with serum estradiol of ≥6000 pg/ml and/or more than 30 follicles, or where coasting or other preventive measures for managing OHSS had been applied, were not included in the present study cohort.…”

“…It has been shown in several earlier studies that a high number of large pre-ovulatory follicles is a secondary risk factor for OHSS, although the classification of follicle size varies between studies [5,13,20,21]. On the other hand, if a patient develops less than 20 large follicles it is generally considered that the risk of developing severe OHSS is low [23,34].…”

“…Concerning BMI, few studies have investigated the impact of this variable a OPEN ACCESS (or body weight) on the risk of developing OHSS and there are conflicting reports in the literature. Navot et al [5], Aramwit et al [25] and Danninger et al [32] observed that patients with OHSS had lower body weight/ BMI than non-OHSS patients, while other investtigators were not able to demonstrate any difference [12,13]. In the present investigation, which included women with a BMI of less than 30 kg/m 2 , there was a tendency (P = 0.121) in the univariable analysis towards lower BMI in the group of patients with ultrasonic evidence of ascites.…”

“…During the 1980s, transvaginal ultrasonography (TVU) became available and a revised classification of OHSS was introduced that included ultrasound-based detection of accumulation of fluid in the peritoneal cavity (ascites) [4]. This classification scheme is still widely employed although modifications for the classification of the most severe forms have been proposed [1,5,6].…”