Risk Factors and Screening for Trypanosoma cruzi Infection of Dutch Blood Donors

Slot, Ed; Hogema, Boris M.; Molier, Michel; Bart, Aldert; Zaaijer, Hans L.

doi:10.1371/journal.pone.0151038

Cited by 12 publications

(8 citation statements)

References 30 publications

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“…Indeed, for Chagas there remains a potential risk to the blood supply given ongoing immigration from endemic countries or vertical transmission from infected mothers . Mitigation in non‐endemic countries is generally addressed through deferral based on risk factor questions, testing of donors identified with risk or in some cases testing alone . Risk of TTB is currently limited to North America, but surprisingly, risk factor questions are used in many non‐endemic countries.…”

Section: Discussionmentioning

confidence: 99%

International survey on the impact of parasitic infections: frequency of transmission and current mitigation strategies

Leiby

O’Brien²,

Wendel

et al. 2018

Vox Sanguinis

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Background and Objectives Globally, blood safety interventions have been successful in mitigating risk of the major transfusion‐transmitted (TT) viruses. However, strategies that address risk from parasites are comparatively limited. TT parasites are often regional in nature, posing unique challenges; we sought to understand their impact on blood safety. Materials and Methods An electronic questionnaire was distributed to transfusion medicine leaders in 100 countries. The survey focused on specific questions pertaining to four parasitic diseases: babesiosis, Chagas, leishmaniasis and malaria. Respondents provided data on historical TT cases, local epidemiology, policies to mitigate risk and an assessment of public health perceptions for each aetiologic agent. Results Twenty‐eight (28%) surveys were returned from countries in Europe (n = 13), the Americas (n = 6), Africa (n = 4), Asia (n = 3) and Oceana (n = 2). Historically, no cases of TT leishmaniasis were reported, TT babesiosis was exclusive to Canada and the USA, TT Chagas was limited to the Americas and Spain, while TT malaria was cosmopolitan. Mitigation efforts varied widely; malaria was the most frequently tested parasitic disease. The public's perception of risk for parasitic agents was low, while that of health authorities in endemic countries was higher. Conclusion The global impact of parasitic infections on blood safety and related mitigation efforts varied widely by parasite epidemiology, test availability, public health priorities and socioeconomic constraints. While parasites continue to pose a risk to blood safety, the successful mitigation of viral risk has elevated the prominence of TT parasites in many locations, thereby requiring consideration of mitigation efforts.

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Section: Discussionmentioning

confidence: 99%

International survey on the impact of parasitic infections: frequency of transmission and current mitigation strategies

Leiby

O’Brien²,

Wendel

et al. 2018

Vox Sanguinis

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“…In Europe, a systematic screening of at-risk blood donations for T. cruzi infection was first implemented in the United Kingdom (1999) followed by Spain (2005), France and Sweden (2009), and more recently in Switzerland (2012), and Belgium (2013) (103). The highest rates of positive serology were observed in Italy (3.9% of 128 blood donors) (116), Spain (1.91% of 1,201) (117), France (0.31% of 972) (118), Switzerland (0.08 of 1,183) (119), United Kingdom (0.007% of 38.585) (120), while no case was observed in the Netherlands (0% of 1,333) (121). Since 2003 Australia has tested 154 donors at risk of CD, with an estimated risk of T. cruzi transmission of 0.04% (92).…”

Section: The New Scenario Of Chagas Diseasementioning

confidence: 99%

Chagas Disease: From Discovery to a Worldwide Health Problem

Lidani

Andrade

Bavia

et al. 2019

Front. Public Health

426

329

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Carlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in his honor, just over a century ago. He described the clinical aspects of the disease, characterized by its etiological agent ( Trypanosoma cruzi ) and identified its insect vector. Initially, CD occurred only in Latin America and was considered a silent and poorly visible disease. More recently, CD became a neglected worldwide disease with a high morbimortality rate and substantial social impact, emerging as a significant public health threat. In this context, it is crucial to better understand better the epidemiological scenarios of CD and its transmission dynamics, involving people infected and at risk of infection, diversity of the parasite, vector species, and T. cruzi reservoirs. Although efforts have been made by endemic and non-endemic countries to control, treat, and interrupt disease transmission, the cure or complete eradication of CD are still topics of great concern and require global attention. Considering the current scenario of CD, also affecting non-endemic places such as Canada, USA, Europe, Australia, and Japan, in this review we aim to describe the spread of CD cases worldwide since its discovery until it has become a global public health concern.

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“…Chagas disease (American trypanosomiasis) is a chronic systemic disease caused by protozoan parasite Trypanosoma cruzi . Chagas disease carries high morbidity and mortality in endemic countries [ 25 , 26 ]. It is estimated that there are 10 million people infected with T. cruzi , most of them living in Latin America [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Parasitic Infections Associated with Unfavourable Outcomes in Transplant Recipients

Wołyniec

Sulima²,

Renke

et al. 2018

Medicina

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Introduction. The immunosuppression used after transplantation (Tx) is associated with an increased risk of opportunistic infections. In Europe, parasitic infections after Tx are much less common than viral, bacterial and fungal ones. However, diseases caused by parasites are very common in tropical countries. In the last years the number of travellers with immunosuppression visiting tropical countries has increased. Methods. We performed a literature review to evaluate a risk of parasitic infections after Tx in Europe. Results. There is a real risk of parasitic infection in patients after Tx travelling to tropical countries. Malaria, leishmaniasis, strongyloidiasis and schistosomiasis are the most dangerous and relatively common. Although the incidence of these tropical infections after Tx has not increased, the course of disease could be fatal. There are also some cosmopolitan parasitic infections dangerous for patients after Tx. The greatest threat in Europe is toxoplasmosis, especially in heart and bone marrow recipients. The most severe manifestations of toxoplasmosis are myocarditis, encephalitis and disseminated disease. Diarrhoea is one of the most common symptoms of parasitic infection. In Europe the most prevalent pathogens causing diarrhoea are Giardia duodenalis and Cryptosporidium. Conclusions. Solid organ and bone marrow transplantations, blood transfusions and immunosuppressive treatment are associated with a small but real risk of parasitic infections in European citizens. In patients with severe parasitic infection, i.e., those with lung or brain involvement or a disseminated disease, the progression is very rapid and the prognosis is bad. Establishing a diagnosis before the patient’s death is challenging.

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Risk Factors and Screening for Trypanosoma cruzi Infection of Dutch Blood Donors

Cited by 12 publications

References 30 publications

International survey on the impact of parasitic infections: frequency of transmission and current mitigation strategies

International survey on the impact of parasitic infections: frequency of transmission and current mitigation strategies

Chagas Disease: From Discovery to a Worldwide Health Problem

Parasitic Infections Associated with Unfavourable Outcomes in Transplant Recipients

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