Risk Factors Associated with Complication Following Gastrectomy for Gastric Cancer: Retrospective Analysis of Prospectively Collected Data Based on the Clavien–Dindo System

Lee, Kyung-Goo; Lee, Hyuk-Joon; Yang, Jun-Young; Oh, Seung-Young; Bard, Slava; Suh, Yun-Suhk; Suh, Yun-Suhk; Yang, Han‐Kwang

doi:10.1007/s11605-014-2525-1

Cited by 126 publications

(103 citation statements)

References 31 publications

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“…Previous studies reported that age was a significant predictive factor for postoperative morbidity after gastric cancer surgery [8,9]. In our study, consistent with these studies, the overall morbidity rate was higher in the elderly group (26.3 vs. 16.1%, p < 0.001), while there were no significant differences in operative factors such as the type of gastrectomy, extent of lymph node dissection, or combined resection of the spleen and/or pancreas.…”

Section: Discussionsupporting

confidence: 91%

Impact of Gastric Cancer Surgery in Elderly Patients

Wakahara

Ueno²,

Maeda³

et al. 2017

Oncology

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Objectives: This study aimed to investigate the validity of gastric cancer surgery in elderly patients. Methods: A total of 544 patients who underwent elective gastrectomy for gastric cancer were divided into an elderly group (age ≥75 years, n = 171) and a control group (age <75 years, n = 373). The clinicopathological data of the patients were reviewed. Results: The overall morbidity rate (26.3 vs. 16.1%, p = 0.005) and the incidence rate of anastomotic leakage (6.4 vs. 1.6%, p = 0.003) were significantly higher in the elderly group. The proportion of patients who had severe complications (≥grade IIIa) was relatively higher in the elderly group (10.5 vs. 5.7%); however, the difference was not significant (p = 0.074). A stage-matched survival analysis revealed no significant differences between the groups (stage I: p = 0.978; stage II: p = 0.964; stage III: p = 0.199). For the pathological stages II and III, the overall survival of the patients in the elderly group who received adjuvant chemotherapy for >3 months was significantly better than that of the patients who received it for ≤3 months or did not receive it (p = 0.023). Conclusions: An aggressive treatment strategy should be adopted in selected elderly patients with gastric cancer.

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Section: Discussionsupporting

confidence: 91%

Impact of Gastric Cancer Surgery in Elderly Patients

Wakahara

Ueno²,

Maeda³

et al. 2017

Oncology

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“…In our records they are represented by only 4 patients (5.4%). However, similar results were reported by other studies in larger series [2].…”

Section: Discussionsupporting

confidence: 92%

“…In our study, age is not a significant risk factor for complications, conversely other studies [2] [14] consider it a risk factor and the authors discourage this kind of surgery in older people.…”

Section: Discussioncontrasting

confidence: 63%

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Complications Following Surgery for Gastric Cancer: Analysis of Prospectively Collected Data

Bruno¹,

Barni²,

Pacciani³

et al. 2014

JCT

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Background and Aims: The complication rate after surgery for gastric cancer varies according to the particular definition of morbidity, so it's necessary to report them using a standardized method, the Clavien-Dindo system. The purpose of this study was to prospectively analyze all postgastrectomy complications in patients with gastric adenocarcinoma according to the severity grade using Clavien-Dindo system, in order to identify risk factors for postoperative complications and their prognostic significance on survival. Methods: This study is based on data from 90 consecutive patients who underwent gastrectomy for gastric neoplasia between January 2010 and February 2014 at the same unit. 15 patients were excluded (benign tumors, GISTs, missing data). Complications were categorized according to the Clavien-Dindo classification (uncomplicated patients vs patients classified ≥Grade I). The following risk factors were studied: age, BMI, sex, operation method, extent of resection, duration of surgery, transfusions, TNM staging, and lymph node ratio. Multivariate logistic regression was used to evaluate the association between risk factors and presence of complications. To assess the effect on overall survival, after selection of covariates using backward elimination, the Cox proportional hazard model was applied. L. Bruno et al. 1455Some variables can predict the risk of postoperative complications, the occurrence of which is a predictor of reduced probability of survival. In this respect it's essential to reduce complications.

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“…It plays a key role in maintaining colloid osmotic pressure, as well as acting as a transport vehicle for intrinsic metabolites, drugs, and anti-oxidative agents [11]. Low serum albumin reflects inflammatory activity and has been reported as a risk factor of post-operative complications and survival in various cancer types [9,[12][13][14][15]]. …”

Section: Introductionmentioning

confidence: 99%

Pre-operative serum albumin is associated with post-operative complication rate and overall survival in patients with epithelial ovarian cancer undergoing cytoreductive surgery

Ataseven

Bois

Reinthaller

et al. 2015

Gynecologic Oncology

140

104

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Risk Factors Associated with Complication Following Gastrectomy for Gastric Cancer: Retrospective Analysis of Prospectively Collected Data Based on the Clavien–Dindo System

Abstract: Age and the extent of gastrectomy were revealed as the prognostic factors for overall complications and the complications of grade IIIa or over according to the Clavien-Dindo classification following gastrectomy for gastric cancer.

Cited by 126 publications

References 31 publications

Impact of Gastric Cancer Surgery in Elderly Patients

Impact of Gastric Cancer Surgery in Elderly Patients

Complications Following Surgery for Gastric Cancer: Analysis of Prospectively Collected Data

Pre-operative serum albumin is associated with post-operative complication rate and overall survival in patients with epithelial ovarian cancer undergoing cytoreductive surgery

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