Risk factors associated with development of pulmonary impairment after tuberculosis

Gandhi, Kalpesh; Gupta, Sanjay; Singla, Rupak

doi:10.1016/j.ijtb.2016.01.006

Cited by 17 publications

(14 citation statements)

References 13 publications

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“…As shown in previous studies, [19,27] clinical factors associated with poorer QoL (e.g., old age, male sex, smoking history, lower BMI, and lower education level) were more common in post-TB subjects with obstructive ventilatory disorders than in those with normal ventilation. Approximately 72% of post-TB subjects with obstructive ventilatory disorders in this study were current or ex-smokers.…”

Section: Discussionsupporting

confidence: 68%

Impact of Ventilatory Disorders on Respiratory Symptoms, Physical Activity, and Quality of Life in Post-Tuberculosis Subjects: A National Database Study in Korea

Yang

Choi

Shin

et al. 2021

Preprint

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BackgroundTuberculosis (TB) survivors experience post-TB lung damage and ventilatory function disorders. However, the proportions of obstructive and restrictive ventilatory disorders as well as normal ventilation among post-TB subjects are unknown. In addition, the impacts of ventilatory disorder and its severity on respiratory symptoms, physical activity limitations, and the quality of life in post-TB subjects remain unclear.MethodsSubjects who participated in the Korean National Health and Nutritional Examination Survey 2007–2016 were enrolled in this study. We evaluated the impact of each ventilatory disorder and its severity on respiratory symptoms, physical activity limitations, and quality of life (measured by the EuroQoL five dimensions questionnaire [EQ-5D] index values) in post-TB subjects.Results Among 1,466 post-TB subjects, 29% and 16% had obstructive ventilatory disorders and restrictive ventilatory disorders, respectively. Mild and moderate obstructive ventilatory disorders were not associated with respiratory symptoms, physical activity limitation, or EQ-5D index value compared with normal ventilation; however, severe obstructive ventilatory disorders were associated with more respiratory symptoms (adjusted odds ratio [aOR] = 5.82, 95% confidence interval [CI] = 2.80–12.10), more physical activity limitation (aOR = 92.20, 95% CI = 16.33–520.62), and decreased EQ-5D index (adjusted coefficient = -0.055, 95% CI = -0.096 – -0.013) compared with normal ventilation. Mild restrictive ventilatory disorders were associated with more respiratory symptoms (aOR = 1.95, 95% CI = 1.07–3.56) compared with normal ventilation, while moderate (aOR = 9.17, 95% CI = 1.02–82.22) and severe restrictive symptoms (aOR = 9.17, 95% CI = 1.02–82.22) were associated with physical activity limitation compared with normal ventilation.ConclusionAmong post-TB subjects, 29% and 16% developed obstructive and restrictive ventilatory disorders, respectively. Severe obstructive ventilatory disorder was associated with more respiratory symptoms, more physical activity limitation, and poorer quality of life, while severe restrictive ventilatory disorder was associated with more physical activity limitations.

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Section: Discussionsupporting

confidence: 68%

Impact of Ventilatory Disorders on Respiratory Symptoms, Physical Activity, and Quality of Life in Post-Tuberculosis Subjects: A National Database Study in Korea

Yang

Choi

Shin

et al. 2021

Preprint

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“…As shown in previous studies [ 20 , 28 ], clinical factors associated with poorer QoL (e.g., old age, male sex, smoking history, lower BMI, and lower education level) were more common in subjects with prior TB with obstructive ventilatory disorders than in those with normal ventilation. Approximately 72% of subjects with prior TB with obstructive ventilatory disorders in this study were current or ex-smokers.…”

Section: Discussionsupporting

confidence: 59%

Association of Ventilatory Disorders with Respiratory Symptoms, Physical Activity, and Quality of Life in Subjects with Prior Tuberculosis: A National Database Study in Korea

Yang

Choi

Shin

et al. 2021

JPM

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Tuberculosis (TB) survivors experience post-TB lung damage and ventilatory function disorders. However, the proportions of obstructive and restrictive ventilatory disorders as well as normal ventilation among subjects with prior TB are unknown. In addition, the impacts of ventilatory disorder and its severity on respiratory symptoms, physical activity limitations, and the quality of life in subjects with prior TB remain unclear. Subjects who participated in the Korean National Health and Nutritional Examination Survey 2007–2016 were enrolled in this study. We evaluated the impact of each ventilatory disorder and its severity on respiratory symptoms, physical activity limitations, and quality of life (measured by the EuroQoL five dimensions questionnaire [EQ-5D] index values) in subjects with prior TB. Among 1466 subjects with prior TB, 29% and 16% had obstructive ventilatory disorders and restrictive ventilatory disorders, respectively. Mild and moderate obstructive ventilatory disorders were not associated with respiratory symptoms, physical activity limitations, or EQ-5D index value compared with normal ventilation; however, severe obstructive ventilatory disorders were associated with more respiratory symptoms (adjusted odds ratio [aOR] = 13.62, 95% confidence interval [CI] = 4.64–39.99), more physical activity limitation (aOR = 218.58, 95% CI = 26.82–1781.12), and decreased EQ-5D index (adjusted coefficient = −0.06, 95% CI = (−0.12–−0.10) compared with normal ventilation. Mild restrictive ventilatory disorders were associated with more respiratory symptoms (aOR = 2.10, 95% CI = 1.07–4.14) compared with normal ventilation, while moderate (aOR = 5.71, 95% CI = 1.14–28.62) and severe restrictive ventilatory disorders (aOR = 9.17, 95% CI = 1.02–82.22) were associated with physical activity limitation compared with normal ventilation. In conclusion, among subjects with prior TB, 29% and 16% developed obstructive and restrictive ventilatory disorders, respectively. Severe obstructive ventilatory disorder was associated with more respiratory symptoms, more physical activity limitation, and poorer quality of life, while severe restrictive ventilatory disorder was associated with more physical activity limitations.

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“…Previous studies have shown obstructive, 14 restrictive, 7,13,19 or mixed pattern 8,15,20 to be the most common PFT abnormality.…”

Section: Discussionmentioning

confidence: 93%

Post-tuberculosis sequelae and their correlation with quality of life: An observational study at a tertiary care center of north India

Aggarwal

Ghosh

Bhan

et al. 2021

Preprint

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Background Lung impairment is a frequently recognised outcome in patients treated for pulmonary tuberculosis (TB). The impact of post-TB sequelae is not only restricted to clinical outcomes but also includes the quality of life and psycho-social well-being. However the magnitude of involvement of quality of life and the likely factors determining it are not clear. In this study, we assess the degree of compromise of quality of life and its determinants in patients of post-TB sequelae. Methods Patients >18 years of age with a history of pulmonary tuberculosis were included in the study. Clinical history, pulmonary function test (PFT) and chest radiographs were recorded. The severity of dyspnea was evaluated using mMRC; quality of life assessment (QoL) was done using two standardized questionnaires- St. George's Respiratory Questionnaire (SGRQ) and Seattle Obstructive Lung Disease Questionnaire (SOLQ). Results A total of 90 participants (mean age 40.4+/-11.6 years; 60 [66.7%] males) were recruited in the study. Overall, 93.3% (95% CI: 86.1%-97.5%) were currently symptomatic. A total of 96.8% (61/63) patients had abnormal pulmonary function test results, out of which 61.9% (39/63) had a mixed type. Out of 65 patients with chest radiographs available, 60 (92.3%,95% CI:84.6-96.8) patients had abnormalities with 45 (69.2%,95% CI: 58.3-78.2) having bilateral chest radiographic abnormalities. On assessment of QoL by SGRQ, the average score obtained was 42.3+/-24.0 (95% CI:37.3-47.3), with Symptoms being the most affected domain. On using SOLQ, Treatment satisfaction (mean score 38.5+/-21.7, 95% CI:34-43) and Physical function (mean score 66.6+/-23.7, 95% CI:61.6-71.6) were the most affected. Neither spirometry results nor chest radiograph severity score could significantly account for the reduction of QoL. There was also a significant correlation between most of the parameters of SGRQ and SOLQ questionnaires in these patients. Conclusion Persistent respiratory symptoms, radiographic and spirometric abnormalities, were present in most of the patients with post-tubercular sequelae. Quality of life, as measured by SGRQ and SOLQ, was found to be significantly impaired in the majority of patients. Keywords- Tuberculosis sequelae, quality of life, SGRQ, SOLQ

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Risk factors associated with development of pulmonary impairment after tuberculosis

Cited by 17 publications

References 13 publications

Impact of Ventilatory Disorders on Respiratory Symptoms, Physical Activity, and Quality of Life in Post-Tuberculosis Subjects: A National Database Study in Korea

Impact of Ventilatory Disorders on Respiratory Symptoms, Physical Activity, and Quality of Life in Post-Tuberculosis Subjects: A National Database Study in Korea

Association of Ventilatory Disorders with Respiratory Symptoms, Physical Activity, and Quality of Life in Subjects with Prior Tuberculosis: A National Database Study in Korea

Post-tuberculosis sequelae and their correlation with quality of life: An observational study at a tertiary care center of north India

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