Risk factors associated with development of seizures after use of iohexol for myelography in dogs: 182 cases (1998)

Barone, Georgina; Ziemer, Lisa S.; Shofer, Frances S.; Steinberg, Sheldon A.

doi:10.2460/javma.2002.220.1499

Cited by 59 publications

(69 citation statements)

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“…Isso pode ser justificado pelo fato do paciente prossivelmente apresentar um limiar convulsivógeno baixo, pois apesar da dose intermediária utilizada, a crise foi inevitável. Esse resultados concordam com Barone et al (2002), os quais relatam que 5% dos pacientes do seu estudo apresentaram convulsão pós mielografia lombar.…”

Section: Resultsunclassified

“…Segundo Barone et al (2002), uma das principais complicações observadas com a punção lombar na realização de mielografias é a realização inadvertida da epidurografia. Segundo Toombs e Waters (2007), a vantagem da injeção lombar repousa na circulação anterógrada do meio de contraste sob pressão da injeção, podendo ser impulsionado em torno das lesões indutoras de obstrução ao fluxo do LCR.…”

Section: Resultsunclassified

“…O meio de contraste mais utilizado na medicina veterinária é o iohexol (DA COSTA; PARENT; DOBSON, 2011). A incidência de convulsões pós-mielografias com iohexol varia de 0 a 10% e tem sido associada com o peso do paciente (pacientes maiores), o volume de injeção de contraste (volumes maiores), a injeção na cisterna magna, localização da lesão (cervical mais provável), sexo (maior risco em machos) e raça (maior risco em dobermans pinchers) (WHEELER; DAVIES, 1985;LEWIS;HOSGOOD, 1992;HOULTON, 1994;ALLAN;WOOD, 1988;BARONE et al, 2002;DA COSTA;PARENT;DOBSON, 2011;NEWCOMB et al, 2012). A injeção do contraste em L5 e L6 para a mielografia em cães mais leves que 20 kg está associada com taxas mais baixas de convulsão pós-mielografia (BARONE et al, 2002;ISRAEL et al, 2009).…”

Section: Introductionunclassified

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Mielografia lombar no diagnóstico de extrusão do disco intervertebral toracolombar em cães: estudo prospectivo

et al. 2014

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ResumoA extrusão do disco toracolombar é a causa mais comum de compressão extradural da medula espinhal em cães. A mielografia é uma das técnicas mais comumente realizadas para o diagnóstico desta afecção. Objetivou-se avaliar a aplicabilidade e efetividade da técnica de mielografia lombar no diagnóstico de extrusão do disco intervertebral toracolombar em cães, bem como suas principais complicações. Foram utilizados 20 animais que ao exame neurológico apresentaram localização da lesão na região toracolombar e que tiveram indicação de mielografia como método diagnóstico complementar e confirmação do diagnóstico de extrusão do disco no trans-operatório. Avaliou-se a precisão do exame na localização e lateralização da lesão, e as complicações associadas ao procedimento. A mielografia lombar teve acurácia de 95% e 60% para a localização e a lateralização da lesão respectivamente, com complicações mínimas. Palavras-chave: Diagnóstico, medula espinhal, punção lombar AbstractThoracolumbar disk extrusion is the most common cause of extradural compression of the spinal cord in dogs. Myelography is one of the most commonly performed techniques for the diagnosis of this affection. This study aimed to evaluate the applicability and effectiveness of lumbar myelography in the diagnosis of thoracolumbar intervertebral disk extrusion in dogs, as well as its major complications. Twenty dogs were used in this study. Animals were included when neurological examination suggested thoracolumbar spine lesion, myelography was used as a complementary diagnostic method, and diagnosis of disk extrusion was surgically confirmed. The accuracy of the exam to predict location and lateralization of extruded disk material were evaluated, as well as complications associated to the procedure. Lumbar myelography exhibited 95% and 60% accuracy for location and lateralization of the lesion, respectively, with minimal complications.

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Section: Resultsunclassified

Section: Introductionunclassified

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Mielografia lombar no diagnóstico de extrusão do disco intervertebral toracolombar em cães: estudo prospectivo

et al. 2014

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“…In human medicine, 10–50% of syrinxes are not detected using CT myelography 31. In addition, this technique is invasive and is reported to cause adverse effects such as seizures or neurological deterioration 32. Consequently and because of the infrequent use of CT myelography in our clinic, this technique was not used in this study.…”

Section: Discussionmentioning

confidence: 99%

Low‐Field Magnetic Resonance Imaging and Multislice Computed Tomography for the Detection of Cervical Syringomyelia in Dogs

Kromhout

Bree

Broeckx

et al. 2015

Veterinary Internal Medicne

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BackgroundSyringomyelia (SM) is defined as the presence of fluid‐containing cavities within the parenchyma of the spinal cord. Sagittal magnetic resonance (MR) images have been described as the preferred technique for visualizing SM in dogs and humans.ObjectiveTo investigate whether computed tomography (CT) can be used to diagnose SM.AnimalsThirty‐two client‐owned dogs referred for investigation of the cervical spine on magnetic resonance imaging (MRI) and CT.MethodsTwo reviewers retrospectively analyzed sagittal and transverse T1‐weighted spin echo (T1WSE) MR images and CT images from each dog for the presence of SM and, if SM was present, the width (mm, syrinx width [SW]) was measured. The results were analyzed statistically.ResultsFor the presence of SM there was a moderate interobserver agreement for MR (81%, κ = 0.54) and almost perfect agreement for CT (94%, κ = 0.87). There was a moderate intramodality agreement for both observers (observer 1 81%, κ = 0.59; observer 2 81%, κ = 0.57). For measurement of SW the repeatability was the best on the midsagittal T1WSE images (95% repeatability coefficient <0.52 mm) and the reproducibility was the best on midsagittal images in both modalities (95% limits of agreement −0.55–0.45; P = 0.002).Conclusion and Clinical ImportanceBoth techniques can be used to detect SM. Midsagittal MR and CT images are best used for measuring SW. Computed tomography can be used as a diagnostic tool for SM when MRI is not available, but CT cannot replace MRI as the standard screening technique for the detection of SM in Cavalier King Charles Spaniel for breeding purposes.

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“…The lack of homogeneity between data from studies evaluating the potential toxicity of the CM has been related to variations of the individuals in the sample, contrast administration site, gender, race, clinical disease, and number of administrations (LEWIS;HOSGOOD, 1992;BARONE et al, 2002). Thus, the standardization of variables and homogeneity can be obtained with the use of rats as the experimental model.…”

Section: Resultsmentioning

confidence: 99%

Comparative neurotoxicity of iobitridol with iohexol by intracisternal administration in Wistar rats

Mello

Stédile

Gouvêa

et al. 2017

SCA

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Iobitridol is a tri-iodinated contrast agent, and neurotoxicologic studies of the intracisternal administration are scarce and inconclusive. The purpose of this study was to compare the neurotoxicity of iobitridol with iohexol, by intracisternal administration in Wistar rats, for a pre-clinical evaluation of its use as a myelographic agent. The animals, a total of 75, were divided into three experimental groups, iobitridol, iohexol and cerebral artificial fluid (control group), with 25 animals per group. Then, these were divided into five subgroups of five animals each, and given doses of 200, 400, 600, 800 and 1000 mg kg -1 , while the control group received the equivalent volumes of contrast media tested. The animals were evaluated after 5, 15, 30, 60, 120, 180 and 240 min of intracisternal administration of these substances, for signs of depression and excitement, tactile palmar grasp, flexor, extensor, palpebral, papillary and pinna reflexes, surface righting and placing reactions, and with an auditory startle test. The evaluations were assessed daily for seven days with these parameters and their body weight, food, and water intake were also measured. There were no statistically significant differences between groups tested with respect to any of the evaluated parameters. In other words, in this animal model, the iobitridol demonstrated a low neurotoxicologic potential, comparable to that observed with iohexol. Further study with dogs and cats, as an alternative, is suggested. Key words: Contrast media. Cistern. Iodinated contrast. Myelography. Toxicity. ResumoO iobitridol é um meio de contraste tri-iodado, e estudos referentes à neurotoxicidade, com administração subaracnóide são escassos e inconclusivos. O objetivo deste trabalho foi comparar a neurotoxicidade do iobitridol com a do iohexol, por via intracisternal, em ratos Wistar, como avaliação pré-clínica da utilização deste como agente mielográfico. Foram utilizados 75 animais divididos em três grupos experimentais com 25 animais: iobitridol, iohexol e líquido cerebroespinhal artificial (grupo controle). Estes foram subdivididos em cinco subgrupos com cinco animais cada, com doses distintas de 200, 400, 600, 800 e 1000 mg kg -1 , sendo utilizado no grupo controle o volume equivalente aos meios de contraste testados. Os animais foram avaliados após 5, 15, 30, 60, 120, 180 palmar, flexor, extensor, palpebral, pupilar e da pina, reação de endireitamento e posicionamento e resposta auditiva. Nos sete dias subsequentes, os animais foram avaliados diariamente quanto a estes parâmetros, e ainda a massa corporal, a ingestão de ração e de água, foram mensuradas. Não foram observadas diferenças estatisticamente significativas entre os grupos testados com meios de contraste, em nenhum dos parâmetros avaliados. Dessa forma, nesse modelo animal, o iobitridol demonstrou baixa neurotoxicidade, comparável a observada com o iohexol. Sugerem-se mais estudos com cães e gatos para utilização do iobitridol como alternativa. . Palavras-chave: Cisterna. Contraste ...

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Risk factors associated with development of seizures after use of iohexol for myelography in dogs: 182 cases (1998)

Abstract: It is preferential to administer iohexol via the L5-6 intervertebral space to minimize the risk of seizures. Higher prevalence of seizures in large dogs, compared with smaller dogs, may be caused by administration of larger total volumes of contrast agent per volume of CSF.

Cited by 59 publications

References 9 publications

Mielografia lombar no diagnóstico de extrusão do disco intervertebral toracolombar em cães: estudo prospectivo

Mielografia lombar no diagnóstico de extrusão do disco intervertebral toracolombar em cães: estudo prospectivo

Low‐Field Magnetic Resonance Imaging and Multislice Computed Tomography for the Detection of Cervical Syringomyelia in Dogs

Comparative neurotoxicity of iobitridol with iohexol by intracisternal administration in Wistar rats

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