Risk factors associated with falls in elderly patients with type 2 diabetes

Chiba, Yuko; Kimbara, Yoshiyuki; Kodera, Remi; Tsuboi, Yuki; Sato, Ken; Tamura, Yoshiaki; Mori, Seijiro; Ito, Hideki; Araki, Atsushi

doi:10.1016/j.jdiacomp.2015.05.016

Cited by 68 publications

(58 citation statements)

References 35 publications

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“…We screened 1273 citations and included 17 studies with a total of 1498358 participants in the meta-analysis (Bonds et al, 2010, Chiba et al, 2015, Duckworth et al, 2011, Hsu et al, 2013, Origin Trial Investigators et al, 2013, Johnston et al, 2012, Johnston et al, 2011, Khunti et al, 2015, Majumdar et al, 2013, McCoy et al, 2012, Rajpathak et al, 2015, Rathmann et al, 2013, Signorovitch et al, 2013, Zhao et al, 2012, Zoungas et al, 2010. The flow chart of the study selection in shown in the supplementary eFigure.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies provided participants with diaries and glucose meters (Origin Trial Investigators et al, 2013) (Bonds et al, 2010) and two studies relied on questionnaires (Chiba et al, 2015) ( McCoy et al, 2012). Two of the studies relied on routine trial monitoring (Duckworth et al, 2011) (Zoungas et al, 2010.…”

Section: Measurement Of Hypoglycemic Eventsmentioning

confidence: 99%

“…Twelve studies measured adverse events through database or medical records codes and one study relied on a professional interviewer with questionnaire (Chiba et al, 2015).…”

Section: Measurement Of Adverse Eventsmentioning

confidence: 99%

“…There are four studies reporting on falls (Chiba et al, 2015) ( Signorovitch et al, 2013) with a pooled odds ratio of 1.89 (95% Confidence Interval 1.54, 2.32) and moderate heterogeneity (chi-squared p= 0.16, I 2 =43%).…”

Section: Association Between Hypoglycaemia and Falls Or Fractures (Fimentioning

confidence: 99%

“…Bloomfield et al found evidence for an association between severe hypoglycaemia and all-cause mortality, neurological events, hospital and emergency department utilization and decreased quality of life, but there was insufficient data on cardiovascular disease, falls and traumatic injuries (Bloomfield et al, 2012). More recent evidence has since emerged from an observational study reporting an association between hypoglycaemia and falls, whilst a meta-analysis of six studies revealed a significantly increased likelihood of cardiovascular disease associated with severe hypoglycaemia (Chiba et al, 2015) (Goto et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients

Mattishent

Loke

2016

Journal of Diabetes and its Complications

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Aims:We aimed to conduct a meta-analysis of serious adverse events (macro-and micro-vascular events, falls and fractures, death) associated with hypoglycaemia in older patients. Methods:We searched MEDLINE and EMBASE spanning a ten-year period up to March 2015 (with automated PubMed updates to October 2015). We selected observational studies reporting on hypoglycaemia and associated serious adverse events, and conducted a meta-analysis. We assessed study validity based on ascertainment of hypoglycaemia, adverse events and adjustment for confounders. Conclusion:Our meta-analysis raises major concerns about a range of serious adverse events associated with hypoglycaemia. Clinicians should prioritize individualized therapy and closer monitoring strategies to avoid hypoglycaemia in susceptible older patients.

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Section: Resultsmentioning

confidence: 99%

Section: Measurement Of Hypoglycemic Eventsmentioning

confidence: 99%

“…Twelve studies measured adverse events through database or medical records codes and one study relied on a professional interviewer with questionnaire (Chiba et al, 2015).…”

Section: Measurement Of Adverse Eventsmentioning

confidence: 99%

Section: Association Between Hypoglycaemia and Falls Or Fractures (Fimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients

Mattishent

Loke

2016

Journal of Diabetes and its Complications

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Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition

Conley

Adib²,

Adler

et al. 2019

Journal of Bone and Mineral Research

171

111

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Osteoporosis‐related fractures are undertreated, due in part to misinformation about recommended approaches to patient care and discrepancies among treatment guidelines. To help bridge this gap and improve patient outcomes, the American Society for Bone and Mineral Research assembled a multistakeholder coalition to develop clinical recommendations for the optimal prevention of secondary fracture among people aged 65 years and older with a hip or vertebral fracture. The coalition developed 13 recommendations (7 primary and 6 secondary) strongly supported by the empirical literature. The coalition recommends increased communication with patients regarding fracture risk, mortality and morbidity outcomes, and fracture risk reduction. Risk assessment (including fall history) should occur at regular intervals with referral to physical and/or occupational therapy as appropriate. Oral, intravenous, and subcutaneous pharmacotherapies are efficacious and can reduce risk of future fracture. Patients need education, however, about the benefits and risks of both treatment and not receiving treatment. Oral bisphosphonates alendronate and risedronate are first‐line options and are generally well tolerated; otherwise, intravenous zoledronic acid and subcutaneous denosumab can be considered. Anabolic agents are expensive but may be beneficial for selected patients at high risk. Optimal duration of pharmacotherapy is unknown but because the risk for second fractures is highest in the early post‐fracture period, prompt treatment is recommended. Adequate dietary or supplemental vitamin D and calcium intake should be assured. Individuals being treated for osteoporosis should be reevaluated for fracture risk routinely, including via patient education about osteoporosis and fractures and monitoring for adverse treatment effects. Patients should be strongly encouraged to avoid tobacco, consume alcohol in moderation at most, and engage in regular exercise and fall prevention strategies. Finally, referral to endocrinologists or other osteoporosis specialists may be warranted for individuals who experience repeated fracture or bone loss and those with complicating comorbidities (eg, hyperparathyroidism, chronic kidney disease). © 2019 American Society for Bone and Mineral Research.

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Hypoglycemia and hyperglycemia are risk factors for falls in the hospital population

Berra

Fazio²,

Azzolini

et al. 2019

Acta Diabetol

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Risk factors associated with falls in elderly patients with type 2 diabetes

Cited by 68 publications

References 35 publications

Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients

Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients

Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition

Hypoglycemia and hyperglycemia are risk factors for falls in the hospital population

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