Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study

Hung, Shih-Chang; Liao, Kuan‐Fu; Lai, Shih‐Wei; Li, Chia‐Ing; Chen, Wen‐Chi

doi:10.1186/1471-230x-11-111

Cited by 67 publications

(48 citation statements)

References 37 publications

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“…The prevalence of gallstones in Taiwan's general population is around 4.3-14.4%, and the prevalence of cholecystectomy for cholelithiasis is around 43.6-61.6 per 100,000 persons [18,19]. In our study, the incidence of newly developed gallstone disease is 7.4%, which is comparable to two recent Korean studies [11,12].…”

Section: Discussionsupporting

confidence: 77%

Analysis of gallstone disease after gastric cancer surgery

et al. 2017

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Background The incidence rate of newly developed gallstone disease after gastrectomy for gastric cancer is thought to be higher than that in the general population. However, the presentation and management of these gallstones remain under debate, and the role of prophylactic cholecystectomy remains questionable. Methods Data on adult patients who were diagnosed with gastric cancer and received gastrectomy between 2000 and 2011 were extracted from the Taiwan National Health Insurance Research Database. A patient was excluded if he or she had gallstone disease or received cholecystectomy before the index date. The incidence of newly developed gallstone disease and its subsequent management were recorded. Data were analyzed to evaluate the factors associated with gallstone development and treatment options. Results A total of 17,325 gastric cancer patients who underwent gastrectomy were eligible for analysis. During the follow-up period (mean 4.1 years; median, 2.9 years), 1280 (7.4%) patients developed gallstone disease and 560 (3.2%) patients subsequently underwent cholecystectomy. The in-hospital mortality for cholecystectomy was 1.8% (10/560). Development of gallstone disease was associated with older age, total gastrectomy, duodenal exclusion, diabetes, cirrhosis, and more comorbidities. Factors associated with the use of cholecystectomy to treat gallstone disease included younger age, fewer comorbidities, medical center admission, and presentation as cholecystitis. Conclusions Although few patients required further gallbladder removal after gastrectomy for gastric malignancy, the increased mortality rate for subsequent cholecystectomy was worth noting. The decision to undergo prophylactic cholecystectomy might be individualized based upon patient characteristics and the surgeon's discretion.

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Section: Discussionsupporting

confidence: 77%

Analysis of gallstone disease after gastric cancer surgery

et al. 2017

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“…gallstones) has been previously considered as a disease of the West due to its association with diet and obesity [2–4]. Symptomatic cholelithiasis is often treated by cholecystectomy [5], removal of the gallbladder, with varying rates of elective and non-elective cholecystectomies worldwide [6–8].…”

Section: Introductionmentioning

confidence: 99%

Cholelithiasis and the risk of liver cancer: results from cohort studies of 134 546 Chinese men and women

Vogtmann

Shu

et al. 2014

J Epidemiol Community Health

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Background Cholelithiasis and cholecystectomy have been proposed as risk factors for liver cancer, but findings have been inconsistent. We assessed this association using data from the Shanghai Women’s and Men’s Health Studies. Methods History of cholelithiasis and cholecystectomy were reported at baseline and follow-up interviews and liver cancer diagnoses were ascertained from the Shanghai Cancer Registry and Vital Statistics Unit. Adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs) were calculated after adjustment for potential confounders. Results A history of cholelithiasis and cholecystectomy was reported by 9.5% and 3.6% of participants at baseline, respectively. After a total of 859,882 person-years of follow-up for women and 391,093 for men, incident liver cancer was detected in 160 women and 252 men. A positive association was observed between a history of cholelithiasis or cholecystectomy and liver cancer in men (aHR 1.46; 95% CI: 1.02, 2.07) and women (aHR 1.55; 95% CI: 1.06, 2.26). Similar results were observed for cholelithiasis only, but cholecystectomy did not reach statistical significance. There was no strong evidence for detection bias of liver cancer due to cholelithiasis or cholecystectomy. Conclusion Our study suggests that cholelithiasis and possibly cholecystectomy may increase the risk of liver cancer.

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“…Gallstones represent a significant burden for health care systems worldwide and are one of the most common disorders presenting to emergency room [1]. It was once considered a disease of western world but due to changes in food pattern, now it is becoming an increasingly common cause of morbidity, leading to hospital admission in the developing world [2].…”

Section: Introductionmentioning

confidence: 99%

Assessment of gallstone predictor: comparative analysis of ultrasonographic and biochemical parameters

Aslam¹,

Saleem²,

Edhi³

et al. 2013

Int Arch Med

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BackgroundGallstones represent a significant burden for health care systems worldwide and are one of the most common disorders presenting to emergency room. Ultrasonography, complete blood picture test and liver function tests are procedures of choice in suspected gallstones or biliary diseases. They are the most sensitive, specific, non-invasive and inexpensive tests for the detection of gallstones. Our main objective was to evaluate the relationship of ultrasonographic findings, hemolytic indices and liver function tests with gallstones.MethodologyIt was a prospective study carried out in Civil Hospital Karachi (DUHS) and Liaquat National Hospital, two largest tertiary care hospitals of Karachi, Pakistan. Duration of the study was from July 2011 to October 2012. The study was carried out on diagnosed, pre-operative and symptomatic patients of cholelithiases. Exclusion criteria were patients of gallbladder and pancreatic carcinoma, emergency operations, patients having age <12 years and non-cooperative patients, who refused to give written consent for participation in the study. Total two tests were performed on each patient after diagnosis by ultrasonography. These were complete blood count and liver function tests. All the demographic data, laboratory findings and ultrasonographic features were noted in a pre-structured Performa. Sample size was calculated by using open-epidemiological sample size calculator prevalence (p) = 35%, d = 5%, and confidence interval (CI) 95% = 350. All the data was entered and analyzed through SPSS 19.ResultThere were 454 diagnosed and pre-operative cases of gallstones present in the study. There were 120(26.4%) males and 334(73.6%) females, with a mean age of 42.80 ± 12.26 years. Most of the suspects had multiple stones 384 (84.5%) while few had single stones 70(15.4%). Fatty liver was found to be present in 144(31.7%) patients and 92(20.2%) had hepatomegaly. Splenomegaly was present in 16(3.5%) patients. Alkaline phosphatase was elevated in 186(41.0%) patients while SGPT was found to be raised in 160(35.2%). Blood urea nitrogen was found to be elevated in 186(41%) patients and serum creatinine was elevated in 46(10.1%) patients.ConclusionIn the light of findings it is recommend that all patients should go through the process of ultrasonography and all the biochemical parameters should be analyzed before surgery.

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Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study

Cited by 67 publications

References 37 publications

Analysis of gallstone disease after gastric cancer surgery

Analysis of gallstone disease after gastric cancer surgery

Cholelithiasis and the risk of liver cancer: results from cohort studies of 134 546 Chinese men and women

Assessment of gallstone predictor: comparative analysis of ultrasonographic and biochemical parameters

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