Risk Factors Associated With Vestibular Nerve Schwannomas

Corona, Ana Paula; Ferrite, Sílvia; Lopes, Márcia da Silva; Rêgo, Marco Antônio Vasconcelos

doi:10.1097/mao.0b013e3182487fee

Cited by 20 publications

(17 citation statements)

References 35 publications

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“…The study by Schoemaker, et al 14 found that the risk of acoustic neuroma was not significantly reduced in participants who had a history of head trauma (OR=0.8, 95% CI: 0.6–1.1). The result was consistent with the case-control study by Corona, et al 18 (OR=1.37, 95% CI: 0.66–2.82) and the cohort study by Inskip, et al 37 (RR=0.8, 95% CI: 0.4–1.7). However, one neighborhood-base case-control study indicated a two-fold increase in acoustic neuroma risk in men 30 years or older after a major head trauma.…”

Section: Discussionsupporting

confidence: 91%

“…After searching PubMed and the bibliographies of all identified relevant publications, as well as screening by the inclusion and exclusion criteria, 11 case-control studies were eligible. 11 12 13 14 15 16 17 18 19 20 21 The study authors, publication year, study site, sample size (numbers of case patients and control subjects), type of control, research instruments, and research contents are all listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Earlier studies found that acoustic neuroma risk was not related to consumption of alcohol, history of cancer/diabetes, and family cancer. 11 14 18 …”

Section: Discussionmentioning

confidence: 99%

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Risk Factors of Acoustic Neuroma: Systematic Review and Meta-Analysis

et al. 2016

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PurposeMany epidemiological studies have investigated environmental risk factors for the development of acoustic neuroma. However, these results are controversial. We conducted a meta-analysis of case-control studies to identify any potential relationship between history of noise exposure, smoking, allergic diseases, and risk of acoustic neuroma.Materials and MethodsWe searched PubMed to identify relevant articles. Two researchers evaluated the eligibility and extracted the data independently.ResultsEleven case-control studies were included in our meta-analysis. Acoustic neuroma was found to be associated with leisure noise exposure [odds ratio (OR)=1.33, 95% confidence interval (CI): 1.05–1.68], but not with occupational noise exposure and ever noise exposure (OR=1.20, 95% CI: 0.84–1.72 and OR=1.15, 95% CI: 0.80–1.65). The OR of acoustic neuroma for ever (versus never) smoking was 0.53 (95% CI: 0.30–0.94), while the subgroup analysis indicated ORs of 0.95 (95% CI: 0.81–1.10) and 0.49 (95% CI: 0.41–0.59) for ex-smoker and current smoker respectively. The ORs for asthma, eczema, and seasonal rhinitis were 0.98 (95% CI: 0.80–1.18), 0.91 (95% CI: 0.76–1.09), and 1.52 (95% CI: 0.90–2.54), respectively.ConclusionOur meta-analysis is suggestive of an elevated risk of acoustic neuroma among individuals who were ever exposed to leisure noise, but not to occupational noise. Our study also indicated a lower acoustic neuroma risk among ever and current cigarette smokers than never smokers, while there was no significant relationship for ex-smokers. No significant associations were found between acoustic neuroma and history of any allergic diseases, such as asthma, eczema, and seasonal rhinitis.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

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Risk Factors of Acoustic Neuroma: Systematic Review and Meta-Analysis

et al. 2016

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“…In the German part of Interphone, medical ionising radiation gave OR = 0.97, 95% CI=0.54–1.75 for acoustic neuroma ( 19 ) . In a study from Brazil on 44 acoustic neuroma patients and 104 controls, exposure to >1 cranial X-ray investigation gave OR = 4.55; 95% CI = 1.10–19.2 ( 20 ) . …”

Section: Discussionmentioning

confidence: 99%

Pooled analysis of case-control studies on acoustic neuroma diagnosed 1997–2003 and 2007–2009 and use of mobile and cordless phones

Hardell

Carlberg

Söderqvist

et al. 2013

International Journal of Oncology

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We previously conducted a case-control study of acoustic neuroma. Subjects of both genders aged 20–80 years, diagnosed during 1997–2003 in parts of Sweden, were included, and the results were published. We have since made a further study for the time period 2007–2009 including both men and women aged 18–75 years selected from throughout the country. These new results for acoustic neuroma have not been published to date. Similar methods were used for both study periods. In each, one population-based control, matched on gender and age (within five years), was identified from the Swedish Population Registry. Exposures were assessed by a self-administered questionnaire supplemented by a phone interview. Since the number of acoustic neuroma cases in the new study was low we now present pooled results from both study periods based on 316 participating cases and 3,530 controls. Unconditional logistic regression analysis was performed, adjusting for age, gender, year of diagnosis and socio-economic index (SEI). Use of mobile phones of the analogue type gave odds ratio (OR) = 2.9, 95% confidence interval (CI) = 2.0–4.3, increasing with >20 years latency (time since first exposure) to OR = 7.7, 95% CI = 2.8–21. Digital 2G mobile phone use gave OR = 1.5, 95% CI = 1.1–2.1, increasing with latency >15 years to an OR = 1.8, 95% CI = 0.8–4.2. The results for cordless phone use were OR = 1.5, 95% CI = 1.1–2.1, and, for latency of >20 years, OR = 6.5, 95% CI = 1.7–26. Digital type wireless phones (2G and 3G mobile phones and cordless phones) gave OR = 1.5, 95% CI = 1.1–2.0 increasing to OR = 8.1, 95% CI = 2.0–32 with latency >20 years. For total wireless phone use, the highest risk was calculated for the longest latency time >20 years: OR = 4.4, 95% CI = 2.2–9.0. Several of the calculations in the long latency category were based on low numbers of exposed cases. Ipsilateral use resulted in a higher risk than contralateral for both mobile and cordless phones. OR increased per 100 h cumulative use and per year of latency for mobile phones and cordless phones, though the increase was not statistically significant for cordless phones. The percentage tumour volume increased per year of latency and per 100 h of cumulative use, statistically significant for analogue phones. This study confirmed previous results demonstrating an association between mobile and cordless phone use and acoustic neuroma.

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“…Most [4][5][6][7], but not all [8], studies examining the association between self-reported occupational noise exposure and VS have found a direct association. In contrast, two studies estimating occupational noise exposure via a job exposure matrix did not find an association [3,9].…”

Section: Introductionmentioning

confidence: 99%