Risk factors for antimicrobial resistance in patients with Escherichia coli bacteraemia related to urinary tract infection

Balfour, James; Barclay, Mabel; Danial, Janathan; Philip, Carol; Perry, Meghan; Etherson, Michelle; Henderson, Naomi

doi:10.1016/j.infpip.2022.100248

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Moreover, the bacterial strains more sensitive to O. campechianum EO can cause intestinal (e.g., abdominal pain, vomiting, bloody diarrhoea) and extra-intestinal (e.g., urinary tract infections, peritonitis, septicaemia, pneumonia, and meningitis) diseases, up to sepsis in the worst cases. These possible consequences stress once more the importance of the antimicrobial results of O. campechianum EO [33][34][35]. Given the promising results, an HP-TLC antimicrobial bioautographic assay was performed on K. oxytoca to detect the main effective compound(s) (Figure 3).…”

Section: Antimicrobial Activity: Mic Of the Eos And Growth Inhibition...mentioning

confidence: 99%

A Comparative Study on Chemical Compositions and Biological Activities of Four Amazonian Ecuador Essential Oils: Curcuma longa L. (Zingiberaceae), Cymbopogon citratus (DC.) Stapf, (Poaceae), Ocimum campechianum Mill. (Lamiaceae), and Zingiber officinale Roscoe (Zingiberaceae)

et al. 2023

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Essential oils (EOs) and their vapour phase of Curcuma longa (Zingiberaceae), Cymbopogon citratus (Poaceae), Ocimum campechianum (Lamiaceae), and Zingiber officinale (Zingiberaceae) of cultivated plants grown in an Amazonian Ecuador area were chemically characterised by Gas Chromatography-Flame Ionization Detector (GC-FID), Gas Chromatography–Mass Spectrometry (GC-MS), and Head Space–Gas Chromatograph-Flame Ionization Detector–Mass Spectrometry (HS-GC-FID-MS).figure The EOs analyses led to the identification of 25 compounds for C. longa (99.46% of the total; ar-turmerone: 23.35%), 18 compounds for C. citratus (99.59% of the total; geraniol: 39.43%), 19 compounds for O. campechianum (96.24% of the total; eugenol: 50.97%), and 28 for Z. officinale (98.04% of the total; α-Zingiberene: 15.45%). The Head Space fractions (HS) revealed C. longa mainly characterised by limonene and 1,8-cineole (37.35%) and α-phellandrene (32.33%); Z. officinale and C. citratus showed camphene (50.39%) and cis-Isocitral (15.27%) as the most abundant compounds, respectively. O. campechianum EO revealed a higher amount of sesquiterpenes (10.08%), mainly characterised by E-caryophyllene (4.95%), but monoterpene fraction remained the most abundant (89.94%). The EOs were tested for antioxidant, antimicrobial, and mutagen-protective properties and compared to the Thymus vulgaris EO as a positive reference. O. campechianum EO was the most effective in all the bioactivities checked. Similar results emerged from assaying the bioactivity of the vapour phase of O. campechianum EO. The antioxidant and antimicrobial activity evaluation of O. campechianum EO were repeated through HP-TLC bioautography assay, pointing out eugenol as the lead compound for bioactivity. The mutagen-protective evaluation checked through Ames’s test properly modified evidenced a better capacity of O. campechianum EO compared with the other EOs, reducing the induced mutagenicity at 0.1 mg/plate. However, even with differences in efficacy, the overall results suggest important perspectives for the functional use of the four studied EOs.

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Section: Antimicrobial Activity: Mic Of the Eos And Growth Inhibition...mentioning

confidence: 99%

A Comparative Study on Chemical Compositions and Biological Activities of Four Amazonian Ecuador Essential Oils: Curcuma longa L. (Zingiberaceae), Cymbopogon citratus (DC.) Stapf, (Poaceae), Ocimum campechianum Mill. (Lamiaceae), and Zingiber officinale Roscoe (Zingiberaceae)

et al. 2023

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The evidence-based new vista to wane the utilization of antimicrobials in UTIs

Kholy,

Wahsh,

Batiha

et al. 2024

Futur J Pharm Sci

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Background In recent years, antibiotic resistance rates have become a global concern for clinicians to combat the pathogenic bacteria associated with UTIs. The objective of this current paper is to explore the evidence-based use of natural products as an alternative strategy to reduce the recurrence rates among different UTI patient populations such as pregnant women, postmenopause women, and children. Main body Commonly used non-antimicrobial products to treat and prevent UTIs include vaginal estrogen, cranberry, probiotics, D-mannose, hyaluronic acid (HA), Chinese herbal medicine, and ascorbic acid. Literature supports the safety and effectiveness of utilizing these products in different UTI patients to a great extent. The strongest recommendation was given to the utilization of vaginal estrogen replacement therapy in postmenopausal females to prevent rUTI. Conclusion We believe our research is the first to provide evidence-based clinical practice guidelines and insight into UTI management using non-antimicrobial drugs in different populations. Our findings can guide future research on the reduction of antimicrobial misuse and preventing antimicrobial resistance. Graphical Abstract

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The Importance of Diagnostics in the Treatment of Urinary Tract Infections in the United Kingdom

Irvine,

Watt,

Kurth

et al. 2024

RRU

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Current diagnosis of urinary tract infections (UTIs) in the UK initially relies on self-reported patient symptoms with no point-of-care test robust enough to accurately identify the causative pathogen and inform on antibiotic susceptibility. In serious UTI cases, standard urine culture is regarded as the gold standard for diagnosis and involves direct isolation, culture and antibiotic susceptibility testing of pathogens. These methods are not suitable in initial UTI diagnosis and treatment because of the time taken to conduct these analyses (≥3 days). Inaccurate and slow diagnostics can lead to unnecessary or incorrect antibiotic prescribing, which can lead to increased antimicrobial resistance and poorer patient outcomes. Novel point-of-care testing devices are urgently needed to improve the diagnostics of UTIs. In this article, we highlight novel point-of-care tests which are in development that can detect UTI-causing pathogens rapidly and accurately. These devices require additional studies to prove their clinical utilities. Adoption of these technologies can empower general practitioners (GPs) and pharmacists in prescribing decisions and improve antimicrobial stewardship.

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Risk factors for antimicrobial resistance in patients with Escherichia coli bacteraemia related to urinary tract infection

Cited by 3 publications

References 14 publications

A Comparative Study on Chemical Compositions and Biological Activities of Four Amazonian Ecuador Essential Oils: Curcuma longa L. (Zingiberaceae), Cymbopogon citratus (DC.) Stapf, (Poaceae), Ocimum campechianum Mill. (Lamiaceae), and Zingiber officinale Roscoe (Zingiberaceae)

A Comparative Study on Chemical Compositions and Biological Activities of Four Amazonian Ecuador Essential Oils: Curcuma longa L. (Zingiberaceae), Cymbopogon citratus (DC.) Stapf, (Poaceae), Ocimum campechianum Mill. (Lamiaceae), and Zingiber officinale Roscoe (Zingiberaceae)

The evidence-based new vista to wane the utilization of antimicrobials in UTIs

The Importance of Diagnostics in the Treatment of Urinary Tract Infections in the United Kingdom

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