Risk factors for gallbladder cancer: A polish case‐control study

Zatoński, Witold; Vecchia, Carlo La; Przewoźniak, Krzysztof; Maisonneuve, Patrick; Lowenfels, Albert B.; Boyle, Peter

doi:10.1002/ijc.2910510508

Cited by 108 publications

(95 citation statements)

References 21 publications

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“…Our study, based on 157 cases, found no strong evidence for an association between green-yellow vegetables or fruit intake. This is consistent with a previous cohort mortality study conducted in Japan (Hirayama, 1981), although case -control studies have reported significant protective effects for fruit and vegetables (Kato et al, 1989) and intakes of vitamins C and E (Zatonski et al, 1992). Our study also found no evidence for a strong association between fruit and vegetables consumption and pancreas cancer mortality, which is consistent with other cohort studies (Hirayama, 1981;Zheng et al, 1993;Shibata et al, 1994;Ziegler et al, 1996;Stolzenberg-Solomon et al, 2002), although the numbers of cases in all of these studies, including ours, may be too small to detect a moderate association.…”

Section: Discussionsupporting

confidence: 92%

Vegetables and fruit intake and cancer mortality in the Hiroshima/Nagasaki Life Span Study

et al. 2003

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The association between green-yellow vegetables and fruit consumption and risk of cancer death was investigated in a prospective study of 38 540 men and women who were atomic-bomb survivors in Hiroshima and Nagasaki, Japan. Study participants completed a dietary questionnaire in 1980 -1981 and were followed-up for cancer deaths until March 1998, during which time 3136 cancer deaths were identified. Daily or almost daily fruit consumption was associated with a significant 12% reduction in total cancer mortality (RR ¼ 0.88; 95% CI, 0.80 -0.96 for daily intake compared with intake once per week or less). Daily or almost daily greenyellow vegetables consumption was associated with a marginally significant 8% reduction in total cancer mortality (0.92; 0.94 -1.01). Green-yellow vegetables consumption was associated with a significant reduction in liver cancer mortality (0.75; 0.60 -0.95). Fruit consumption was associated with a significantly reduced risk of stomach cancer and lung cancer mortality (0.80; 0.65 -0.98). Greenyellow vegetables and fruit consumption was associated with a reduction in oesophageal cancer, but these associations were not statistically significant. Neither green-yellow vegetables nor fruit consumption was associated with colorectal cancer or breast cancer mortality. These results support the evidence that daily consumption of fruit and vegetables reduces the risk of total cancer, and specifically cancers of the stomach, liver, and lung.

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Section: Discussionsupporting

confidence: 92%

Vegetables and fruit intake and cancer mortality in the Hiroshima/Nagasaki Life Span Study

et al. 2003

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“…In addition to gallstones, the risk factors for gallbladder cancer, such as obesity, insulin resistance, high-fat or high-caloric diet and altered lipid metabolism tend to run in families 8,9,12,32 (Hsing AW, Rashid A, Sakoda L, Deng J, Han T, Wang BS, Shen MC, Fraumeni JF Jr., Gao YT. Gallstones and the risk of biliary tract cancer: a population-based study.…”

Section: Discussionmentioning

confidence: 99%

“…Ethnic and familial predisposition suggests the role of genetic predisposition or shared metabolic and lifestyle factors, including obesity, insulin resistance, or high-fat, high-caloric diet. 1,[6][7][8] Familial aggregation of gallstones has been reported in several studies, [9][10][11] but only one assessed the role of family history of gallstones in biliary tract cancer etiology. A case-control study of gallbladder cancer in Bolivia and Mexico reported that a family history of gallstones was associated with a 3.6-fold risk of gallbladder cancer.…”

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confidence: 99%

Family history of gallstones and the risk of biliary tract cancer and gallstones: A population‐based study in Shanghai, China

Hsing

Bai

Andreotti

et al. 2007

Intl Journal of Cancer

110

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Cancers of the biliary tract arise from the gallbladder, extrahepatic bile ducts and ampulla of Vater. Although relatively uncommon, the incidence of biliary tract cancer rose more than 100% in Shanghai, China between 1972 and1994. Gallstones are the predominant risk factor for biliary tract cancers, with over 60% of the cancer cases having gallstones. A familial tendency to gallstones has been reported and may elevate the risk of gallbladder cancer further. As part of a large population-based case-control study of biliary tract cancers in Shanghai, China, we examined the association between a family history of gallstones and biliary tract cancers as well as biliary stones. A total of 627 biliary tract cancers (368 gallbladder, 191 bile duct, 68 ampulla of Vater), 1,037 biliary stone cases (774 gallbladder, 263 bile duct) and 959 healthy subjects randomly selected from the population were included in this study. Information on family history of gallstones among firstdegree relatives (i.e., parents, siblings, offspring) was obtained through a self-reported history during in-person interviews. A family history of gallstones was associated with increased risks of biliary stones [odds ratio (OR) 5 2.8, 95% confidence interval (CI) 5 2.1-3.8], gallbladder cancer (OR 5 2.1, 95% CI 5 1.4-3.3) and bile duct cancer (OR 5 1.5, 95% CI 5 0.9-2.5), after adjustment for age, gender, marital status, education, smoking, alcohol drinking and body mass index. For gallbladder cancer, subjects with gallstones but without a family history of gallstones had a 21-fold risk (95% CI 14.8-30.1), while those with both gallstones and a positive family history had a 57-fold risk (95% CI 32.0-110.5). Significant risks for gallbladder cancer persisted after additional adjustment for gallstones, and when the analysis was restricted to subjects with first-degree relatives whose gallstones were treated with cholecystectomy. The significant associations with a family history of gallstones were seen for all first-degree relatives, including parents, siblings and offspring, but not spouses. This large population-based study not only supports the role of gallstones in biliary carcinogenesis but also suggests that the underlying genetic or lifestyle determinants of stones within families contribute to the risk of biliary tract cancer. ' 2007 Wiley-Liss, Inc.Key words: biliary tract cancer; cholelithiasis; familial aggregation; genetic susceptibility; China Biliary tract cancers, encompassing tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, are relatively uncommon malignancies in most parts of the world. 1 The highest incidence rates have been observed among Native Americans and Hispanics living in the Southwestern United States and among some populations in Central and South America, Eastern Europe and certain parts of Asia. 1,2 Between 1972 and 1994, the incidence rates for biliary tract cancer rose more rapidly than those for any other malignancy in Shanghai, China, with increases of 119% among men and 124% among women. 3 Th...

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“…We identified eight cohort studies Wolk et al, 2001;Calle et al, 2003;Samanic et al, 2004Samanic et al, , 2006Engeland et al, 2005;Kuriyama et al, 2005;Oh et al, 2005) and four case -control studies (Zatonski et al, 1992(Zatonski et al, , 1997Strom et al, 1995;Serra et al, 2002) that reported results on overweight/obesity and risk of gallbladder cancer. One case -control study (Zatonski et al, 1992) was excluded because this study was included in a multicentre case -control study (Zatonski et al, 1997); the multicentre casecontrol study was included in this meta-analysis.…”

Section: Study Selectionmentioning

confidence: 99%

“…One case -control study (Zatonski et al, 1992) was excluded because this study was included in a multicentre case -control study (Zatonski et al, 1997); the multicentre casecontrol study was included in this meta-analysis.…”

Section: Study Selectionmentioning

confidence: 99%

Obesity and the risk of gallbladder cancer: a meta-analysis

2007

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We performed a meta-analysis of studies of the association between excess body weight and risk of gallbladder cancer identified from MEDLINE and EMBASE databases from 1966 to February 2007 and the references of retrieved articles. A random-effects model was used to combine results from eight cohort studies and three case -control studies, with a total of 3288 cases. Compared with individuals of 'normal weight', the summary relative risk of gallbladder cancer for those who were overweight or obese was 1.15 (95% CI, 1.01 -1.30) and 1.66 (95% CI, 1.47 -1.88) respectively. The association with obesity was stronger for women (relative risk, 1.88; 95% CI, 1.66 -2.13) than for men (relative risk, 1.35; 95% CI, 1.09 -1.68). There was no statistically significant heterogeneity among the results of individual studies. This meta-analysis confirms the association between excess body weight and risk of gallbladder cancer.

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Risk factors for gallbladder cancer: A polish case‐control study

Cited by 108 publications

References 21 publications

Vegetables and fruit intake and cancer mortality in the Hiroshima/Nagasaki Life Span Study

Vegetables and fruit intake and cancer mortality in the Hiroshima/Nagasaki Life Span Study

Family history of gallstones and the risk of biliary tract cancer and gallstones: A population‐based study in Shanghai, China

Obesity and the risk of gallbladder cancer: a meta-analysis

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