Risk Factors for HIV-1 seroconversion among Taiwanese men visiting gay saunas who have sex with men

Chen, Yen–Ju; Lin, Yu Ting; Chen, Marcelo; Huang, Szu-Wei; Lai, Su Fen; Wong, Wing Wai; Tsai, Hung Chin; Lin, Yu Huei; Liu, Hsin‐Fu; Lyu, Shu Yu; Chen, Yi Ming A.

doi:10.1186/1471-2334-11-334

Cited by 14 publications

(15 citation statements)

References 39 publications

(33 reference statements)

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“…The present study reported a 4.38% prevalence of HIV-1 in MSM in Taiwan in 2012. This figure differs from that of a similarly published report that indicated a variable but considerably higher prevalence of HIV-1 among MSM visiting gay saunas in Taiwan between 2001 and 2005 [ 14 ]. According to results of syphilis testing, 2.15% of participants in this study were infected with syphilis.…”

Section: Discussioncontrasting

confidence: 96%

“…Risk factors for HIV infection in MSM include unprotected anal intercourse [ 8 – 11 ], illegal drug use [ 11 – 13 ], a history of other sexually transmitted diseases (STDs) [ 12 ], condom use, multiple sex partners and role during anal intercourse [ 8 , 11 , 14 , 15 ]. Previous studies have shown an association between high level of substance use, sexual risk behavior and risk of HIV infection in young MSM [ 16 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Molecular Epidemiology of HIV-1 Infection among Men who Have Sex with Men in Taiwan in 2012

Huang

Wang

Cowó³

et al. 2015

PLoS ONE

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The number of men who have sex with men (MSM) infected with HIV-1 in Taiwan has increased rapidly in the past few years. The goal of this study was to conduct a molecular epidemiological study of HIV-1 infection among MSM in Taiwan to identify risk factors for intervention. Voluntary counseling program and anonymous testing were provided to patrons at 1 gay bar, 7 night clubs and 3 gay saunas in Taipei and New Taipei Cities in 2012. HIV-1 subtypes were determined using gag subtype-specific PCR and phylogenetic analysis by env sequences. Recent HIV-1 infection was determined using LAg-Avidity EIA. In-depth interviews and questionnaires were used to identify risk factors. The prevalence and incidence of HIV-1 among MSM in Taiwan were 4.38% (53/1,208) and 3.29 per 100 person-years, respectively. Of 49 cases genotyped, 48 (97.9%) were infected with subtype B and 1 with CRF01_AE (2%). Phylogenetic analysis of 46 HIV-1 strains showed that 25 (54.4%) subtype B strains formed 9 clusters with each other or with other local strains. The CRF01_AE case clustered with a reference strain from a Thai blood donor with bootstrap value of 99. Multivariate logistic regression analysis showed that risk factors associated with HIV-1 infection included use of oil-based solution as lubricant (vs. saliva or water-based lubricants, OR= 4.23; p <0.001); exclusively receptive role (vs. insertive role, OR= 9.69; p <0.001); versatile role (vs. insertive role, OR= 6.45; p= 0.003); oral sex (vs. insertive role, OR= 11.93; p= 0.044); times of sexual contact per week (2-3 vs. zero per week, OR= 3.41; p= 0.021); illegal drug use (OR= 4.12; p <0.001); and history of sexually transmitted diseases (OR= 3.65; p= 0.002). In conclusion, there was no new HIV-1 subtype or circulating recombinant form responsible for the increase of HIV-1 among MSM in Taiwan in 2012. Misuse of oil-based solution as lubricant is a new risk factor identified among MSM in Taiwan. The Taiwan’s Centers for Disease Control has created a video (www.youtube.com/watch?v=BinExvvOTMM&feature=iv&src_vid=BW81-PfmY3E&annotation_id=annotation_2436493705) to correct such misconception in its AIDS prevention campaign.

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Section: Discussioncontrasting

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Molecular Epidemiology of HIV-1 Infection among Men who Have Sex with Men in Taiwan in 2012

Huang

Wang

Cowó³

et al. 2015

PLoS ONE

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“…11 studies found circum cision to have a significant protective association with HIV infection among all MSM. 18,41,42,63,64,67,73,76,83,86,90 Two studies found a significant protective association with circumcision only among MSM who primarily engage in insertive anal sex. 25,87 Two studies reported a significant protective association with circum cision only among bisexual men.…”

Section: Resultsmentioning

confidence: 99%

“…Cumulative meta-analysis Men (n) Kreiss et al (1993) 73 Kumta et al (2002) 81 Tabet et al (2002) 86 Golden et al (2003) 67 Buchbinder et al (2005) 63 Millett et al (2007) 78 Millett et al (2007) 78 Reisen et al (2007) 83 Mor et al (2007) 79 Sanchez et al (2009) 84 Templeton et al (2009) 87 Gust et al (2010) 69 McDaid et al (2010) 77 Jameson et al (2010) 71 Jozkowski et al (2010) 72 Zou et al (2010) 91 Sánchez et al (2011) 85 Chen et al (2011) 64 Lane et al (2011) 76 Oster et al (2011) 80 Thornton et al (2011) 89 Lan et al (2011) 66 Gao et al (2012) 19 Clatts et al (2012) 13 Schneider et al (2012) 18 Yunihastuti et al (2012) 90 Hladik et al (2012) 14 Koblin et al (2013) 24 Sanders et al (2013) 26 Griensven et al (2013) 22 Xu et al (2013) 28 Doerner et al (2013) 21 Zhou et al (2013) 30 van Aar et al (2013) 27 Pando et al (2013) 25 Zeng et al (2014) 32 Sullivan et al (2015) 38 Solomon et al (2015) 37 Liu et al (2015) 34 Sathane et al (2016) 42 Sathane et al (2016) 42 Xu et al (2016) 45 Wang et al (2016) …”

Section: Meta-analysismentioning

confidence: 99%

“…Sensitivity analyses detected one study 76 as having some effect on the pooled association estimate between circumcision and HIV infection (appendix). Restricting the meta-analysis to 14 studies 18,30,42,45,63,64,71,73,[76][77][78]80,83,89 that adjusted for potential confounders increased the magnitude of the protective association between circum cision and HIV infection (OR 0·64, 95% CI 0·45-0·93; k=16; I²=87%). 32 (52%) of 62 studies were rated as low risk of bias with all remaining studies rated as high risk of bias (appendix).…”

Section: Increased Odds Of Hiv Infectionmentioning

confidence: 99%

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Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data

Yuan

Fitzpatrick

et al. 2019

The Lancet Global Health

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Background Men who have sex with men (MSM) are disproportionately affected by HIV and other sexually transmitted infections (STIs) worldwide. Previous reviews investigating the role of circumcision in preventing HIV and other STIs among MSM were inconclusive. Many new studies have emerged in the past decade. To inform global prevention strategies for HIV and other STIs among MSM, we reviewed all available evidence on the associations between circumcision and HIV and other STIs among MSM.Methods In this systematic review and meta-analysis, we searched PubMed, Web of Science, BioMed Central, Scopus, ResearchGate, Cochrane Library, Embase, PsycINFO, Google Scholar, and websites of international HIV and STI conferences for studies published before March 8, 2018. Interventional or observational studies containing original quantitative data describing associations between circumcision and incident or prevalent infection of HIV and other STIs among MSM were included. Studies were excluded if MSM could not be distinguished from men who have sex with women only. We calculated pooled odds ratios (ORs) and their 95% CIs using random-effect models. We assessed risk of bias using the Newcastle-Ottawa scale. (0·99, 0·90-1·09; k=20; I²=40%). Circumcision was associated with reduced odds of herpes simplex virus (HSV) infection among MSM overall (0·84, 0·75-0·95; k=5; I²=0%) and penile human papillomavirus (HPV) infection among HIV-infected MSM (0·71, 0·51-0·99; k=3; I²=0%). Findings We identified 62 observational studies including 119 248 MSM. Circumcision was associated with 23% reduced odds of HIV infection among MSM overall (OR 0·77, 95% CI 0·67-0·89; number of estimates [k]=45; heterogeneity I²=77%). Circumcision was protective against HIV infection among MSM in countries of low and middle income (0·58, 0·41-0·83; k=23; I²=77%) but not among MSM in high-income countries Interpretation We found evidence that circumcision is likely to protect MSM from HIV infection, particularly in countries of low and middle income. Circumcision might also protect MSM from HSV and penile HPV infection. MSM should be included in campaigns promoting circumcision among men in countries of low and middle income.In view of the substantial proportion of MSM in countries of low and middle income who also have sex with women, well designed longitudinal studies differentiating MSM only and bisexual men are needed to clarify the effect of circumcision on male-to-male transmission of HIV and other STIs.

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Versatility and HIV Vulnerability: Patterns of Insertive and Receptive Anal Sex in a National Sample of Older Australian Gay Men

2012

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According to mathematical modeling, HIV is more likely to spread through a population of men who have sex with men when high numbers practice versatile anal sex roles, that is, engage in both insertive (IAI) and receptive anal intercourse (RAI). Yet, actual patterns of versatility remain largely unknown, particularly among older men who currently face growing rates of HIV. In this study, 1,135 Australian gay men aged 40 years and older completed a national online survey of their sexual health and behavior over the past 12 months. Of men who had anal intercourse, 62 % engaged in both IAI and RAI. Factors associated with being versatile included younger age (P = 0.01), higher income (P = 0.009), and larger numbers of sexual partners (P = 0.003). Among men with multiple sexual partners, 20 % were highly versatile, that is, reported similar numbers of IAI and RAI partners. Having HIV (P = 0.003) and living in a rural area (P = 0.04) were significantly associated with being highly versatile. These data point to high rates of versatility among older Australian gay men, with implications for mathematical predictions of change in HIV epidemics and for the design of future HIV prevention strategies.

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Risk Factors for HIV-1 seroconversion among Taiwanese men visiting gay saunas who have sex with men

Cited by 14 publications

References 39 publications

Molecular Epidemiology of HIV-1 Infection among Men who Have Sex with Men in Taiwan in 2012

Molecular Epidemiology of HIV-1 Infection among Men who Have Sex with Men in Taiwan in 2012

Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data

Versatility and HIV Vulnerability: Patterns of Insertive and Receptive Anal Sex in a National Sample of Older Australian Gay Men

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