Risk factors for incident mild cognitive impairment – results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)

Abstract

Mild cognitive impairment is frequent in older GP patients. Subjective memory complaints predict incident MCI. Especially vascular risk factors provide the opportunity of preventive approaches.

Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study–Cognition Study

“…9,12 Our incidence rates were similar to those described in population studies that included subjects predominantly aged 85ϩ, and we also found increasing incidence with age. The Leipzig Longitudinal Study found that the incidence of MCI was 76.5/1,000 py among subjects aged 75 or older and 157.6/1,000 py in those 85 years or older, 14 and a recent report from the Mayo Clinic Study of Aging showed an incidence of 90.2/ 1,000 py among subjects aged 80 -84 and 125.2/ 1,000 py among those aged 85-89. 16 Our findings regarding mortality raise a critically important point in the interpretation of these and similar longitudinal data.…”

“…3,[7][8][9][10][11][12][13][14][15][16] The existing data show an incidence in the range of 37 to 77 per 1,000 person-years (py). Individuals with MCI progress to dementia at a rate of 5% to 15% per year, 1,4 although as many as 40% to 50% of the subjects can return to cognitive normality (normal) 3,9 ; thus, the natural history of MCI could be very unstable.…”

“…[1][2][3][4] The prevalence rates of MCI range from 3% to more than 20%, depending on the classification methods (e.g., amnestic vs multiple cognitive domain), 5,6 and although there are extensive data on the incidence of dementia in subjects with MCI, there are few data on the incidence of MCI in cognitively normal subjects. 3,[7][8][9][10][11][12][13][14][15][16] The existing data show an incidence in the range of 37 to 77 per 1,000 person-years (py). 7 Individuals with MCI progress to dementia at a rate of 5% to 15% per year, 1,4 although as many as 40% to 50% of the subjects can return to cognitive normality (normal) 3,9 ; thus, the natural history of MCI could be very unstable.…”

Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

“…Studies of brain activity during cognitive tasks note that subjects with SMC present an increase in activity in comparison with the control group (Rodda et al 2009;Rodda et al 2010;Maestu et al 2010;Jessen et al 2010;Elfgren et al 2010;Gallassi et al 2010;Benito-León et al 2010;Luck et al 2010). All these studies have evaluated the spatial or the spatiotemporal profiles of activity, but none of them assess whether the functional connectivity between brain regions was spared or not in subjects with SMC.…”

Reversion to Normal Cognition and Its Correlates among the Community-dwelling Elderly with Mild Cognitive Impairment: the Longitudinal Cohort Study

“…지장애의 유병률 경도인지장애 발생 관련요인 에 대한 [5,8], [9] 횡단적 연구뿐만 아니라 경도인지장애에서 치매 또는 정상인 , 지로의 진행률 및 관련요인 에 대한 종단적 연구도 활 [7,[10][11][12] 발히 진행되어 왔다 이에 비하여 국내에서는 아직까지 경도 .…”