Risk Factors for Malignant and Atypical Meningiomas

Abstract

Objective: In this study a large series of our patients have been reviewed to determine risk factors for atypical and malignant meningioma, with particular interest paid to previous surgeries, tumor location, patient's age and gender. Methods:The authors reviewed the records of 420 patients who underwent surgery at King Hussein Medical Center between 2003 to 2015 with histologically confirmed meningioma, the age of the patient is the age at time of surgery, pathology grading according to the World Health Organization 2007 guidelines, and tumor location confirmed with preoperative imaging and operative notes.Results: Risk factors for atypical and malignant meningioma included patients with previous surgery had three times increase incidence of atypical or malignant meningiomas, non skull base location and male sex doubled the risk, but the patient's age had no any significance as risk factor. Conclusion:Previous surgery, male sex and non skull-base meningiomas increased the risk for malignant and atypical meningiomas. This increased possibility of recurrence after surgical resection and patients need for radiotherapy (conventional or stereotactic). So, it is important to take these factors regarding the patient's plan of management and prognosis.